This proposal is designed to test the protein leverage hypothesis (PLH) in humans: the idea that the level of food consumption in humans, like other animals, is adjusted to maintain a target protein intake. As the prevalence of overweight and obesity increases, with its attendant health problems, the need to identify which dietary components limit rather than exacerbate energy intake is imperative. According to the PLH, the consumption of a diet low in % protein and high in % fat and carbohydrat ....This proposal is designed to test the protein leverage hypothesis (PLH) in humans: the idea that the level of food consumption in humans, like other animals, is adjusted to maintain a target protein intake. As the prevalence of overweight and obesity increases, with its attendant health problems, the need to identify which dietary components limit rather than exacerbate energy intake is imperative. According to the PLH, the consumption of a diet low in % protein and high in % fat and carbohydrate, typical of many Western countries, inevitably requires the ingestion of additional energy to maintain protein intake constant, thus driving weight gain. Conversely, the consumption of a diet that is relatively high in % protein requires the ingestion of lower levels of energy, creating the potential for weight loss. Preliminary experimental and population-level nutritional survey data support the PLH, as does the finding that protein is more satiating than other macronutrients. If, as predicted, small changes in the proportion of protein in diets described in the current study are found to impact on total energy intake there will be significant implications for weight control strategies. Thus, if the PLH is confirmed, public health dietary recommendations and government policy settings for the food industry will need to change. Large-scale intervention studies aimed at demonstrating the longer term impact on body weight will also be required.Read moreRead less
The Effects Of The Western Diet On Cognition In Rats
Funder
National Health and Medical Research Council
Funding Amount
$689,326.00
Summary
An unhealthy diet can affect how we think. This project will identify mechanisms by which a western diet impairs cognition, and test ways of intervening to reduce the impact of diet on the brain. We will examine changes in inflammation, and markers of nerve growth in a critical brain region, the hippocampus, in response to different periods of diet. We will also test if the diet and our interventions affect the gut biota.
Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
Improving Weight Loss By Intermittent Use Of Very Low Energy Diet: The TANGO Diet Trial (Temporary Phases Of Accelerated Weight Loss For Noticeably Greater Outcomes)
Funder
National Health and Medical Research Council
Funding Amount
$660,736.00
Summary
Very low energy diet (VLED) is being increasingly used for the treatment of obesity, but the resultant weight loss is usually transient, partly because it induces powerful adaptive responses that inhibit weight loss and promote regain. We have shown that 'taking a break from dieting' for 2 weeks reduces these adaptive responses. In this project we will thus test whether weight loss outcomes with VLED can be improved via intermittent use, where periods on the VLED are alternated with 'breaks'.
Effects Of Fast Versus Slow Weight Loss On Fat, Muscle And Bone In Postmenopausal Women
Funder
National Health and Medical Research Council
Funding Amount
$316,450.00
Summary
Very low energy diets (VLED) are increasingly used to treat obesity. Of concern is the fact that VLED induce adaptive responses that can inhibit loss of, and promote regain of, abdominal fat while decreasing lean body mass, muscle strength and bone density. This project will therefore determine whether VLEDs could have negative effects on body composition that increase the risk of metabolic disease, sarcopenia or osteoporosis, and if so, what mechanisms are involved.
Atmospheric composition and climate change. Changing composition and distribution of atmospheric trace gases and aerosols are the driving forces behind changes in climate and the environment at the earth's surface. This proposal is to undertake a program of ground based infrared remote sensing measurements as part of the Network for Detection of Stratospheric Change to investigate some of the most relevant atmospheric processes and species central to the greenhouse effect and ozone depletion. S ....Atmospheric composition and climate change. Changing composition and distribution of atmospheric trace gases and aerosols are the driving forces behind changes in climate and the environment at the earth's surface. This proposal is to undertake a program of ground based infrared remote sensing measurements as part of the Network for Detection of Stratospheric Change to investigate some of the most relevant atmospheric processes and species central to the greenhouse effect and ozone depletion. State-of-the-art measurements, advances in analysis techniques, and the measurement of isotopic fractionation will all contribute to advances in capabilities. Validation of satellite-based remote sensing instruments is also an important facet of the work.Read moreRead less
Better greenhouse gas budgets: new techniques and applications. The most recent (2001) international assessment strongly confirms the link between global climate change and human-induced changes in atmospheric composition. However, improved knowledge of atmospheric trace gas budgets is essential for better modelling of future climate change and formulation of public policy. We have developed novel techniques for atmospheric trace gas and isoptic analysis that provide new tools for resolving trac ....Better greenhouse gas budgets: new techniques and applications. The most recent (2001) international assessment strongly confirms the link between global climate change and human-induced changes in atmospheric composition. However, improved knowledge of atmospheric trace gas budgets is essential for better modelling of future climate change and formulation of public policy. We have developed novel techniques for atmospheric trace gas and isoptic analysis that provide new tools for resolving trace gas budgets in ways not previously possible. We will apply these tools to improve our understanding of the Australian and global budgets of greenhouse gases, especially nitrous oxide and methane, for which sources still have unacceptably large uncertainties.Read moreRead less
Innovative measurement and modelling of greenhouse fluxes at regional scales across Australia. Carbon dioxide accounts for around 60% of the enhanced greenhouse effect. This proposal aims to markedly improve knowledge of the exchange of carbon, mostly as CO2, between atmospheric, ocean and land-based reservoirs in the Australian region. This will be achieved through a suite of measurements using innovative technologies: satellite and ground based remote sensing as well in situ measurements at ....Innovative measurement and modelling of greenhouse fluxes at regional scales across Australia. Carbon dioxide accounts for around 60% of the enhanced greenhouse effect. This proposal aims to markedly improve knowledge of the exchange of carbon, mostly as CO2, between atmospheric, ocean and land-based reservoirs in the Australian region. This will be achieved through a suite of measurements using innovative technologies: satellite and ground based remote sensing as well in situ measurements at Darwin and on the Ghan railway from Darwin to Adelaide. The measurements will be used to constrain inverse models of the carbon cycle and significantly reduce uncertainties in regional carbon source estimates. These estimates will in turn be compared to the Australian National Greenhouse Gas Inventory for comparison and verification.Read moreRead less
The DietAdvice Website A New Innovation For Dietitians In Clinical Practice.
Funder
National Health and Medical Research Council
Funding Amount
$140,975.00
Summary
Due to the growing incidence of obesity within Australia, use of computer technology may be a method of targeting these people by increasing access to dietary services. Currently available dietary software in the Australian context only allows analysis of nutrient information. Thus when a dietitian sees a patient they must manually translate food intake to nutrient information, a largely time consuming exercise. DietAdvice is a website that was developed for people to enter in their own food int ....Due to the growing incidence of obesity within Australia, use of computer technology may be a method of targeting these people by increasing access to dietary services. Currently available dietary software in the Australian context only allows analysis of nutrient information. Thus when a dietitian sees a patient they must manually translate food intake to nutrient information, a largely time consuming exercise. DietAdvice is a website that was developed for people to enter in their own food intakes. The food information is sent to a dietitian who develops individualised dietary advice for them. A pilot study of the website has already found it to be feasible in the primary healthcare setting. Tested for 12 months the website was used by 224 patients from GP practices in the Illawarra region of NSW. Approximately 73% of patients were overweight and patients with a high BMI were 1.88 times more likely to use the website in the comfort of their home. Further research about the website however was needed. The research to follow on from the pilot study will aim to refine the DietAdvice website, leading towards its commercialisation for dietitians in clinical practice. The research will be broken into 3 phases. Phase 1 will involve a usability test of the website, assessing the underlying algorithms and testing it with dietitians in private practice. Phase 2 will see volunteers using the website on multiple occasions after being given pre-weighed amounts of food to eat. This will determine how reliable and accurate the information is; and phase 3 will evaluate whether the website is cost effective and if it increases accessibility of health services especially in rural areas. By confirming these attributes there will be a sound basis to commercialise the product.Read moreRead less
The carbon cycle and climate: new approaches to atmospheric measurements and modelling. Earth's climate is intimately connected to the carbon cycle, which controls atmospheric CO2 through processes such as photosynthesis, respiration and ocean uptake. A thorough understanding of the carbon cycle, and potential feedbacks with climate change, is prerequisite knowledge for informed assessments of future climate, impacts, adaptation and mitigation. This proposal improves that understanding through ....The carbon cycle and climate: new approaches to atmospheric measurements and modelling. Earth's climate is intimately connected to the carbon cycle, which controls atmospheric CO2 through processes such as photosynthesis, respiration and ocean uptake. A thorough understanding of the carbon cycle, and potential feedbacks with climate change, is prerequisite knowledge for informed assessments of future climate, impacts, adaptation and mitigation. This proposal improves that understanding through measurements of CO2 and other key Kyoto-protocol greenhouse gases, links to global networks and satellite measurements, and advanced modelling. Australian science has a very important role to play in international networks due to our unique combination of southern hemisphere location and scientific standing. Read moreRead less