Investigating evidence of control system dynamics in visuomotor skill acquisition using multimodal functional magnetic resonance imaging. This project brings together mathematical and engineering methods with cognitive neuroscience in a novel way to better understand the fundamental processes associated with brain imaging, and the acquisition of motor skills. An improved understanding of the function of regions within the motor network will have a direct benefit for the rehabilitation of patient ....Investigating evidence of control system dynamics in visuomotor skill acquisition using multimodal functional magnetic resonance imaging. This project brings together mathematical and engineering methods with cognitive neuroscience in a novel way to better understand the fundamental processes associated with brain imaging, and the acquisition of motor skills. An improved understanding of the function of regions within the motor network will have a direct benefit for the rehabilitation of patients suffering motor deficits from developmental causes, following traumatic brain injuries, and after stroke and other neurodegenerative diseases. The outcomes of the research will also contribute to our understanding of the complexity of brain networks involved in motor skill acquisition.Read moreRead less
Who acquires infection from whom across international borders? New approaches for control of emerging infections through understanding travel patterns. Mathematical modelling of data on travellers traversing Australia's borders and their contact patterns can be used to understand the pathways by which infectious diseases enter and spread in Australia. Currently available social contact data which informs models are inadequate and outdated. Gathering new data relevant to modern society will help ....Who acquires infection from whom across international borders? New approaches for control of emerging infections through understanding travel patterns. Mathematical modelling of data on travellers traversing Australia's borders and their contact patterns can be used to understand the pathways by which infectious diseases enter and spread in Australia. Currently available social contact data which informs models are inadequate and outdated. Gathering new data relevant to modern society will help control future infectious disease threats to our society. Our aim is to collect detailed, unique data on demography, behavioural and social patterns of travellers and residents, and use this to develop mathematical models to evaluate effective control measures for emerging infections in Australia. This study will make a unique contribution to national disease control policy.Read moreRead less
Bayesian choice modelling. Discrete choice models are important as they provide tools to help understand choice processes of decision makers. It remains a challenge to specify models with covariance structures flexible enough to capture complex patterns of cross-substitution between choices while being able to capture heterogeneity present in individual behaviour. We will develop a Bayesian approach to choice modelling that uses covariance selection to overcome these problems. This will train re ....Bayesian choice modelling. Discrete choice models are important as they provide tools to help understand choice processes of decision makers. It remains a challenge to specify models with covariance structures flexible enough to capture complex patterns of cross-substitution between choices while being able to capture heterogeneity present in individual behaviour. We will develop a Bayesian approach to choice modelling that uses covariance selection to overcome these problems. This will train researchers and raise the profile of Australia in an active research area that is important in the social sciences; substantive applications will be in health economics, but developments will also be relevant to cognate areas of biostatistics, epidemiology, and ecology.Read moreRead less
Choice experiments to improve predictive power for policy makers. In the current economic climate, Australian governments will benefit from superior choice experiments which will lead to improved prediction of the potential public benefit of proposed policy changes. The choice experiments developed here will have a substantial effect on the development of strategies for the promotion and maintenance of a strong health care system as well as being relevant to the maintenance of a sustainable envi ....Choice experiments to improve predictive power for policy makers. In the current economic climate, Australian governments will benefit from superior choice experiments which will lead to improved prediction of the potential public benefit of proposed policy changes. The choice experiments developed here will have a substantial effect on the development of strategies for the promotion and maintenance of a strong health care system as well as being relevant to the maintenance of a sustainable environment, both designated National Research Priority areas. The innovative research proposed will tap into and build strong links with international research networks, advancing Australia's research reputation and providing a rich environment for the training of research graduates.Read moreRead less
Modelling patient flows through hospitals: optimizing effective use of resources. Hospitals are complex, dynamic systems confronted by increased demand in the face of shrinking real capacity. Managing such systems is currently undertaken with sub-optimal analytical support, particularly when demand and capacity are changing and resources must be manipulated to respond to such changes. In this project, the investigators will apply a mathematical modelling approach to the analysis of hospital pati ....Modelling patient flows through hospitals: optimizing effective use of resources. Hospitals are complex, dynamic systems confronted by increased demand in the face of shrinking real capacity. Managing such systems is currently undertaken with sub-optimal analytical support, particularly when demand and capacity are changing and resources must be manipulated to respond to such changes. In this project, the investigators will apply a mathematical modelling approach to the analysis of hospital patient flows. Furthermore, they will employ statistical process control methodologies to the problem of recognising and responding to changes in the flows, so that performance objectives are met. In doing this, they will give health service managers and clinicians a significant advantage in deciding how best to manage a constrained resource to maximize access, throughput and patient outcomes.Read moreRead less
Bayesian statistical models for understanding outcomes and improving decision-making for women screened for breast cancer. This project has two key benefits: (i) the development of frontier statistical methods for spatio-temporal analysis and data synthesis, which are imperative in a wide range of disciplines; and (ii) the application of these methods for improved understanding of breast cancer outcomes for women screened in Queensland. The project results will lead to direct health and financi ....Bayesian statistical models for understanding outcomes and improving decision-making for women screened for breast cancer. This project has two key benefits: (i) the development of frontier statistical methods for spatio-temporal analysis and data synthesis, which are imperative in a wide range of disciplines; and (ii) the application of these methods for improved understanding of breast cancer outcomes for women screened in Queensland. The project results will lead to direct health and financial benefits through targeted policies for increasing screening uptake and reducing cancer morbidity and mortality and therefore health spending in this area. Importantly, the project represents an excellent training opportunity to develop a PhD candidate into an experienced interdisciplinary researcher.Read moreRead less
Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowle ....Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowledge of normal and abnormal developmental processes, especially in embryonic growth. Understanding these processes should lead to prediction and treatment of congenital disorders and contribute to a healthy start to life.Read moreRead less
Doing Bayesian Statistics Better: an Inter-Disciplinary Perspective for Improving Models, Priors, Design and Applications. Through improving methods for data analysis and design, this project increases the capability of individuals, communities and governments to make correct decisions based on data, leading to immeasurable human, social and financial benefits. It will also directly enhance Australia's international research reputation, promote inter-disciplinary links, promote research by wome ....Doing Bayesian Statistics Better: an Inter-Disciplinary Perspective for Improving Models, Priors, Design and Applications. Through improving methods for data analysis and design, this project increases the capability of individuals, communities and governments to make correct decisions based on data, leading to immeasurable human, social and financial benefits. It will also directly enhance Australia's international research reputation, promote inter-disciplinary links, promote research by women in a non-traditional area, keep intellectual property within Australia, train quality undergraduates and postgraduates, and contribute to public good through its focus on applications in key national priorities: health, environment and genetics. Read moreRead less
Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood ....Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood pressure and degree of consciousness in critical care patients.Read moreRead less
Attrition in longitudinal studies: advancing and evaluating statistical methods. Longitudinal studies are a vital tool for monitoring the health and well-being of Australians. They are uniquely placed to examine changes in diseases over time and prospectively collect data on exposure and disease onset. There have been many successful longitudinal studies in Australia that have lead to significant breakthroughs in evidence-based health (e.g. the Nambour Skin Cancer Prevention Trial). Unfortunatel ....Attrition in longitudinal studies: advancing and evaluating statistical methods. Longitudinal studies are a vital tool for monitoring the health and well-being of Australians. They are uniquely placed to examine changes in diseases over time and prospectively collect data on exposure and disease onset. There have been many successful longitudinal studies in Australia that have lead to significant breakthroughs in evidence-based health (e.g. the Nambour Skin Cancer Prevention Trial). Unfortunately all longitudinal studies suffer from attrition, or loss of participants, which leads to questions concerning their validity and generalisability. This project will investigate the causes of attrition, and the effect attrition has on longitudinal studies, in order to improve their design and analysis.Read moreRead less