Revolutionising real-time genomic epidemiology in urban wastewater systems. This project aims to develop a real-time and high-resolution genomic tool to monitor and track pathogens in urban wastewater systems based on the portable third-generation sequencing platform. Pathogens sicken hundreds of millions of people, cost the global economy tens of billions of dollars annually, and are one of the leading causes of death worldwide. The current epidemiology approach, and data, are retrospective and ....Revolutionising real-time genomic epidemiology in urban wastewater systems. This project aims to develop a real-time and high-resolution genomic tool to monitor and track pathogens in urban wastewater systems based on the portable third-generation sequencing platform. Pathogens sicken hundreds of millions of people, cost the global economy tens of billions of dollars annually, and are one of the leading causes of death worldwide. The current epidemiology approach, and data, are retrospective and thus insufficient for timely intervention. Integrated with wastewater analysis for pharmaceuticals targeting pathogens, the sewer-based epidemiology approach of this project will greatly enhance public health by achieving early detection and informed control of infectious diseases.Read moreRead less
Development of strategies for early detection of respiratory microbial infections possibly imported to Australia by humans and animals. The impact of global terrorism, SARS and Avian influenza underlines the importance to Australia of having advanced early-warning systems for airborne disease threats. Our new technique will provide continuous monitoring, rapid detection, and viability reporting on pathogenic microorganisms transmitted by air. The technique is non-invasive and is feasible to anal ....Development of strategies for early detection of respiratory microbial infections possibly imported to Australia by humans and animals. The impact of global terrorism, SARS and Avian influenza underlines the importance to Australia of having advanced early-warning systems for airborne disease threats. Our new technique will provide continuous monitoring, rapid detection, and viability reporting on pathogenic microorganisms transmitted by air. The technique is non-invasive and is feasible to analyse much larger populations of humans and animals with their minimal disturbance. This will benefit Australia and protect the country in the areas of public and animal health, and defence against bioterrorism or biowarfare. The technology has worldwide export potential, creating new high-tech enterprises and jobs.Read moreRead less
Realistic assessment of biomarker transformation in the wastewater system. Wastewater-based epidemiology is an internationally recognised cost-effective tool to monitor population exposure to chemicals and infectious diseases including Covid-19. However, in-sewer degradation of critical biomarkers can limit their wastewater-based epidemiology suitability. This project aims to systematically evaluate the stability of a new suite of potential biomarkers and conduct the first Australia-wide assessm ....Realistic assessment of biomarker transformation in the wastewater system. Wastewater-based epidemiology is an internationally recognised cost-effective tool to monitor population exposure to chemicals and infectious diseases including Covid-19. However, in-sewer degradation of critical biomarkers can limit their wastewater-based epidemiology suitability. This project aims to systematically evaluate the stability of a new suite of potential biomarkers and conduct the first Australia-wide assessment on the impact of biomarker stability on wastewater-based epidemiology estimates using wastewater samples from ~65% of the Australian population. The project expects to generate knowledge to expand the application of wastewater-based epidemiology to reliably quantify exposure and status of well-being even in remote areasRead moreRead less
Sources, fate and exposure pathways for emerging persistent organic pollutants in Australia. Brominated flame retardants and perfluorinated chemicals have received much attention from media and environmental groups. They accumulate in biota and humans and levels are shown to be increasing. It is proposed they be included in the global treaty on persistent organic pollutants (POPs), recently ratified by Australia. This project aims to determine sources, fate and exposure pathways for these che ....Sources, fate and exposure pathways for emerging persistent organic pollutants in Australia. Brominated flame retardants and perfluorinated chemicals have received much attention from media and environmental groups. They accumulate in biota and humans and levels are shown to be increasing. It is proposed they be included in the global treaty on persistent organic pollutants (POPs), recently ratified by Australia. This project aims to determine sources, fate and exposure pathways for these chemicals with an emphasis on exposure to infants. This will provide information for risk assessment development and more effective management of these chemicals. Furthermore, the study's approach and results will contribute to a rationalization of the issues related to emerging POPs. Read moreRead less
Special Research Initiatives - Grant ID: SR0354804
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network on Degraded Environment Assessment and Remediation. There are over 80,000 contaminated sites in Australia and >750,000,000 hectares of land impacted by soil acidity, sodicity, heavy-metals, nutrients and agricultural chemicals. The research network advances assessment, management and remediation of degraded environments (land, water, and air) through collaboration of the research programs developing sustainable solutions. The collective focus is minimising disposal and impac ....ARC Research Network on Degraded Environment Assessment and Remediation. There are over 80,000 contaminated sites in Australia and >750,000,000 hectares of land impacted by soil acidity, sodicity, heavy-metals, nutrients and agricultural chemicals. The research network advances assessment, management and remediation of degraded environments (land, water, and air) through collaboration of the research programs developing sustainable solutions. The collective focus is minimising disposal and impacts of contaminated soil and wastes, and land remediation. By facilitating communication, the network enhances national and international research coordination, interaction with regulators, end-users, industry, and other stakeholders, achievement of critical mass for new initiatives, enhances research training and contributes to a critical National Priority.Read moreRead less
Combating the spread of antibiotic resistance in urban water systems. This projects aims to investigate the occurrence, diversity, and transformation of antibiotic resistant genes in the entire urban water cycle. Using the latest metagenomic and analytical tools, this project will enhance our knowledge on fate and transfer mechanisms of antibiotic resistance genes in the urban water cycle. Based on this understanding, an expected outcome of the project is the development of innovative technologi ....Combating the spread of antibiotic resistance in urban water systems. This projects aims to investigate the occurrence, diversity, and transformation of antibiotic resistant genes in the entire urban water cycle. Using the latest metagenomic and analytical tools, this project will enhance our knowledge on fate and transfer mechanisms of antibiotic resistance genes in the urban water cycle. Based on this understanding, an expected outcome of the project is the development of innovative technologies for efficient reduction of antibiotic resistance genes to have future applications for environmental, human health and economic benefits for Australia.Read moreRead less
Development of strategy for comprehensive protection of Australia against respiratory diseases by real time detection of airborne pathogenic microbes. The project will develop a real time portable bioaerosol detector capable of identifying a presence of targeted microorganisms in the ambient air immediately upon their appearance. The device will become a powerful tool capable of protecting Australia by minimising the possible spread of infectious respiratory diseases causing global pandemics.
Developing a new approach to aquatic pollutant assessment combining time integrated sampling with toxicity testing. Present approaches for monitoring risk of aquatic pollutants are limited to grab sample analysis for specific pollutants using target values and/or ecotoxicological assessment of population biomarkers. This collaborative research, involving 3 universities and 10 industry partners, aims to develop and evaluate a novel approach combining extraction of pollutants using time integrated ....Developing a new approach to aquatic pollutant assessment combining time integrated sampling with toxicity testing. Present approaches for monitoring risk of aquatic pollutants are limited to grab sample analysis for specific pollutants using target values and/or ecotoxicological assessment of population biomarkers. This collaborative research, involving 3 universities and 10 industry partners, aims to develop and evaluate a novel approach combining extraction of pollutants using time integrated passive samplers and toxicological evaluation of extracts using a range of rapid in-vitro and in-vivo assays. The project will produce cost-effective tools for highly sensitive assessment of pollutant effects and ultimately facilitate intervention guidelines based on mixture toxicity.Read moreRead less
Development and calibration of aquatic passive sampler technologies for emerging water pollutants. Contaminated water is a key exposure source for many emerging pollutants either direct via consumption of water or indirect via consumption of aquatic biota. Monitoring of emerging aquatic pollutants remains a challenge. In this project we will develop cost effective monitoring technologies for emerging aquatic pollutants. The outcome will allow a more comprehensive and cost-effective monitoring ....Development and calibration of aquatic passive sampler technologies for emerging water pollutants. Contaminated water is a key exposure source for many emerging pollutants either direct via consumption of water or indirect via consumption of aquatic biota. Monitoring of emerging aquatic pollutants remains a challenge. In this project we will develop cost effective monitoring technologies for emerging aquatic pollutants. The outcome will allow a more comprehensive and cost-effective monitoring of these pollutants and related to that a decrease in risk related to water pollution. Furthermore it will enhance consumer confidence, improve water management and allow more comprehensive identification of emerging risks related to aquatic pollutants.Read moreRead less
Development and evaluation of a Phytotox-Test for field and laboratory testing of phytotoxic chemicals in water. Monitoring of trace pollutants in water is expensive, laborious and requires sophisticated analytical techniques. Building on the research team's new technique, which uses a phyto-tox test based on photosynthesis inhibition in algae, this study will further develop and evaluate methodologies and applications for measuring phyto-toxic chemicals in environmental water samples. The proj ....Development and evaluation of a Phytotox-Test for field and laboratory testing of phytotoxic chemicals in water. Monitoring of trace pollutants in water is expensive, laborious and requires sophisticated analytical techniques. Building on the research team's new technique, which uses a phyto-tox test based on photosynthesis inhibition in algae, this study will further develop and evaluate methodologies and applications for measuring phyto-toxic chemicals in environmental water samples. The project aims specifically to:
- identify suitable algae, sensitive to phyto-toxic chemicals
- determine dose-response for priority pollutants in selected algae
- evaluate critical parameters affecting measurements
- develop pre-concentration techniques.
The outcomes will provide the first on-site trace pollutant testing method allowing more effective management of water pollution
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