Australian Laureate Fellowships - Grant ID: FL150100060
Funder
Australian Research Council
Funding Amount
$2,875,097.00
Summary
The first generation of single entity measurement tools for analysis. The first generation of single entity measurement tools for analysis: This fellowship project aims to develop a new type of diagnostic device that measures single molecules or single cells. Such measurements seek to revolutionise analysis by allowing heterogeneity and rare events in samples to be identified, rather than the average information provided by existing tools. With single molecule devices, the heterogeneity in respo ....The first generation of single entity measurement tools for analysis. The first generation of single entity measurement tools for analysis: This fellowship project aims to develop a new type of diagnostic device that measures single molecules or single cells. Such measurements seek to revolutionise analysis by allowing heterogeneity and rare events in samples to be identified, rather than the average information provided by existing tools. With single molecule devices, the heterogeneity in response enables the development of multiplexed, calibration free sensors. The outcomes of the project are hoped to be completely new thinking on performing measurements, new knowledge regarding heterogeneity in biology and the potential for novel commercialised sensors. It is expected that this will be important not only in biological discovery, but also in providing far more robust sensors for applications such as environmental monitoring, disease prediction, personalised medicine or drug discovery.Read moreRead less
In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual ....In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual biopsies and instant diagnosis without the need for costly and time-consuming histopathological reports. Thus, it will not only drive transformative research but also transform health care delivery. It will also be a major boost to the Australian biotechnology industry with potential for enormous economic benefits.Read moreRead less
Novel technologies for motion-compensated simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging. The aim of this work is to develop motion tracking and motion correction techniques for an emerging hybrid imaging technology, MR-PET. The MR-PET scanner simultaneously acquires structural MR images and functional PET images. The work will provide clearer images without the effects of motion blur for both research and clinical applications.
Sulfur isotope fractionations in Earth evolution. Sulfur isotopes provide a unique window into the major events in Earth's history. Techniques have been developed for measuring all four sulfur isotopes, including the low abundance sulfur-36 (0.02 per cent) to 0.2 per mil, in situ for sulfides. This project will make innovative technological developments to the counting system to extend this capability to the lower count rates obtained from sulfates. This will open windows for research on proces ....Sulfur isotope fractionations in Earth evolution. Sulfur isotopes provide a unique window into the major events in Earth's history. Techniques have been developed for measuring all four sulfur isotopes, including the low abundance sulfur-36 (0.02 per cent) to 0.2 per mil, in situ for sulfides. This project will make innovative technological developments to the counting system to extend this capability to the lower count rates obtained from sulfates. This will open windows for research on processes occurring in the early solar system, atmospheric and hydrologic conditions in the Archean, ore-forming processes, and evolution of life on Earth. Read moreRead less
Radiation detectors to better understand ion interactions. This project aims to build a Heavy Ion Therapy Research and Treatment Centre in Australia. Understanding how ions interact with matter and their radiobiological effectiveness (RBE) is important. The project will introduce an Australian detector technology platform to research ion interaction physics and their RBE. It will develop radiation detectors for ion measurement with a wide energy range, including a practical RBE quality assurance ....Radiation detectors to better understand ion interactions. This project aims to build a Heavy Ion Therapy Research and Treatment Centre in Australia. Understanding how ions interact with matter and their radiobiological effectiveness (RBE) is important. The project will introduce an Australian detector technology platform to research ion interaction physics and their RBE. It will develop radiation detectors for ion measurement with a wide energy range, including a practical RBE quality assurance tool with submillimetre spatial resolution. The proposed Australian radiation detection technology is expected to improve understanding of the scientific mechanisms underpinning the radiobiological effectiveness of heavy ion radiation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101253
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Redox-mediated electrochemiluminescence enhancement for novel biosensors. This project aims to understand and apply a novel approach to the enhancement of diagnostic tests for agricultural biosecurity applications. Government and Industry require simple, rapid tests to monitor and detect threats to Australia’s agricultural biosecurity. This interdisciplinary project intends to enhance collaboration, generate fundamental advances in the field of analytical chemistry and bolster Australia’s resear ....Redox-mediated electrochemiluminescence enhancement for novel biosensors. This project aims to understand and apply a novel approach to the enhancement of diagnostic tests for agricultural biosecurity applications. Government and Industry require simple, rapid tests to monitor and detect threats to Australia’s agricultural biosecurity. This interdisciplinary project intends to enhance collaboration, generate fundamental advances in the field of analytical chemistry and bolster Australia’s research capabilities through new analytical techniques and technologies. The breadth of applications of this technology should also provide significant benefits to the Australian biotechnology industry, improve existing instrumentation and impact diverse research fields from biosecurity to health monitoring.
Read moreRead less
Probing the limits of Gravitational Force Sensing. This project will develop innovative laser measurement topologies for probing the limits of gravitational force sensing. Of particular interest is the detection of gravitational waves from astrophysical sources. Technology developed in this project will be able to see gravitational forces from slow moving mass at great distances away. Implementation of this technology will enhance the terrestrial gravitational wave detectors to observe at lower ....Probing the limits of Gravitational Force Sensing. This project will develop innovative laser measurement topologies for probing the limits of gravitational force sensing. Of particular interest is the detection of gravitational waves from astrophysical sources. Technology developed in this project will be able to see gravitational forces from slow moving mass at great distances away. Implementation of this technology will enhance the terrestrial gravitational wave detectors to observe at lower frequencies. This project will ensure Australia's continued involvement in the international Advanced LIGO (Laser Interferometer Gravitational Observatory) project and guarantee Australian participation in the first direct detection of gravitational waves.Read moreRead less
Unlocking the potential of quantitative x-ray micro-tomography. This project aims to build on two new ideas in data acquisition and 3D image reconstruction to bring 3D X-ray microscopy or computed tomography (CT) into advanced research use as well as common industrial applications. In the past 10 years, CT has improved our understanding in areas ranging from the evolution of life and osteoporosis to composite material failure and oil recovery. However, the full potential of CT remains unrealised ....Unlocking the potential of quantitative x-ray micro-tomography. This project aims to build on two new ideas in data acquisition and 3D image reconstruction to bring 3D X-ray microscopy or computed tomography (CT) into advanced research use as well as common industrial applications. In the past 10 years, CT has improved our understanding in areas ranging from the evolution of life and osteoporosis to composite material failure and oil recovery. However, the full potential of CT remains unrealised because crucial features in structure and composition are overlooked by simplistic algorithms. Users cannot directly capture quantities of interest such as key compositional variation or defects, and workflows are poorly adapted for large-scale use in industrial fabrication or phenomics. This project aims to address these shortcomings using advanced mathematics and algorithms.Read moreRead less