Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzy ....Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzymatic reactions through which the analyte will convert to much simpler, reactive and hence measurable molecules. This project will enable to design miniaturised sensors for point-of-care detection of biomolecules that cannot be yet evaluated by the end users.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100043
Funder
Australian Research Council
Funding Amount
$435,279.00
Summary
High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super ....High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super-solution imaging of single molecules in live cells. This facility will provide capability for researchers pursuing industry transformation and other initiatives in the development of advanced materials, biomolecular sciences, nanotechnology, photonics and device engineering.Read moreRead less
Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevi ....Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100035
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Hyperpolarised gas functional lung and molecular imaging. This project will produce a polariser to generate magnetised gas for research with magnetic resonance imaging (MRI). This allows imaging of normal and abnormal lung ventilation and circulation in animal and humans. The use of these hyperpolarised gases can also be used to tag specific molecules and increase understanding of lung metabolism.
How electric fields can facilitate reversible protein binding to surfaces. The aim of this project is to develop the first biosensors that prevent nonspecific protein adsorption and allow reversible protein binding. The project expects to achieve this using a combination of novel surface chemistry and pulsed electric fields that dynamically change a sensing interface. The impact of electric fields on the binding of proteins to this interface will be followed using a novel single molecule fluores ....How electric fields can facilitate reversible protein binding to surfaces. The aim of this project is to develop the first biosensors that prevent nonspecific protein adsorption and allow reversible protein binding. The project expects to achieve this using a combination of novel surface chemistry and pulsed electric fields that dynamically change a sensing interface. The impact of electric fields on the binding of proteins to this interface will be followed using a novel single molecule fluorescence microscope previously developed that can locate the position of proteins with 2 nanometer resolution. The expected outcomes of this project is a class of biosensor that can continuously monitor protein biomarkers for wearable sensors that provide information on a user’s wellness and nutrition.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100846
Funder
Australian Research Council
Funding Amount
$418,388.00
Summary
Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a ne ....Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a new strategy to brighten the upconversion nanomaterials. This project should push upconversion nanoscience to a new generation and provide significant benefits in ultra-sensitive biomolecular assays and in vivo bioimaging.Read moreRead less
Rapid detection of rare-event cells by strong UP-conversion
encoded nano-radiators (SUPER Dots): finding a needle in a haystack. Current diagnostic tests are not sensitive enough to detect cancer in its very early stages or early recurrence following treatment. The new technologies developed by this project will be able to find single cancer cells in blood and urine samples heralding a new era in medical diagnostics.
Beyond Spectral Detection: Engineering SUPER Dot Probes for High-Throughput Discovery. Molecules that are altered as a result of a pathological condition are generally present in very low abundance, and pose a “needle-in-a-haystack” problem. Current detection, quantification and localisation technologies use fluorescent probes that are limited by sensitivity and analysis time. This project will develop a new generation of nanophotonic luminescent probes (Strong Upconversion Photo-stable Encoded ....Beyond Spectral Detection: Engineering SUPER Dot Probes for High-Throughput Discovery. Molecules that are altered as a result of a pathological condition are generally present in very low abundance, and pose a “needle-in-a-haystack” problem. Current detection, quantification and localisation technologies use fluorescent probes that are limited by sensitivity and analysis time. This project will develop a new generation of nanophotonic luminescent probes (Strong Upconversion Photo-stable Encoded nano-Radiators (SUPER) Dots), based on purpose-engineered up-conversion nanocrystals that are ultra-bright and have low background interference, high specificity, speed, and large-scale multiplexing capacity. These probes will allow microscopy and flow cytometry to measure hitherto undetectable rare-event molecules and cells, opening new frontiers for the discovery of new biomarkers.Read moreRead less
Novel technologies for motion-compensated simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging. The aim of this work is to develop motion tracking and motion correction techniques for an emerging hybrid imaging technology, MR-PET. The MR-PET scanner simultaneously acquires structural MR images and functional PET images. The work will provide clearer images without the effects of motion blur for both research and clinical applications.