Genotypes And Phenotypes Of Human Primary Non-congenital Antibody Deficiency
Funder
National Health and Medical Research Council
Funding Amount
$544,692.00
Summary
Antibodies represent a key component of the immune system, and a particularly important in defence against bacterial and viral infections. In some individuals, antibody production fails, rendering them more susceptible to infection. In most cases, the mechanism of antibody failure is unknown. This project seeks to determine the genetic and cellular mechanisms of antibody failure. This could improve diagnosis for immune deficiency, and improve our overall understanding of the immune system.
The multiplexed diagnosis of arbovirus infections using combinatorial probes. Viruses that cause serious diseases such as hemorrhagic fever or encephalitis must be quickly identified. Diagnostic tests based on DNA hybridisation are accurate and can be rapid but they are expensive. We will test a method for simplifying DNA tests and increasing their capabilities. DNA probes for detecting arboviruses will be designed at the ANU using new bioinformatic methods and their reliability will be model ....The multiplexed diagnosis of arbovirus infections using combinatorial probes. Viruses that cause serious diseases such as hemorrhagic fever or encephalitis must be quickly identified. Diagnostic tests based on DNA hybridisation are accurate and can be rapid but they are expensive. We will test a method for simplifying DNA tests and increasing their capabilities. DNA probes for detecting arboviruses will be designed at the ANU using new bioinformatic methods and their reliability will be modelled using all the available genetic information. Computer predictions will be experimentally tested in the PANBIO laboratory by using the probes to detect viral nucleic acids. The influence of virus genome complexity will be investigatedRead moreRead less
Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. This project aims to develop a novel biosensor prototype based on CYBERNOSE® technology to rapidly identify volatile traces of illicit drugs and precursor chemicals in concealed environments. The CYBERNOSE® technology employs sensors using the highly sophisticated and sensitive olfactory receptors of microscopic nematode worms linked to an optoelectronic det ....Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. This project aims to develop a novel biosensor prototype based on CYBERNOSE® technology to rapidly identify volatile traces of illicit drugs and precursor chemicals in concealed environments. The CYBERNOSE® technology employs sensors using the highly sophisticated and sensitive olfactory receptors of microscopic nematode worms linked to an optoelectronic detector. The need for rapid, non-contact screening devices to detect and identify illicit drugs and precursors entering Australia has never been greater. Law enforcement agencies should directly benefit from the capability to more rapidly screen people and cargo, improving efficiency of illicit drug detection and protection of our borders.Read moreRead less
Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The ser ....Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The serological tests to be developed aim to be species-specific tests to detect the most important chlamydial sheep pathogens. This in turn endeavours to improve domestic surveillance, reducing on-farm losses and costs, and improve market opportunities for Australian sheep exporters as well as informing veterinary populations on best practice treatment.Read moreRead less
Digital Interferometry: A platform technology for robust optical measurements. Digital interferometry is a new concept which will allow the measurement precision of interferometry to be applied in otherwise inaccessible or unsuitable environments. It will enhance the performance of major scientific instruments, such as gravitational wave detectors and optical telescopes, whilst reducing the cost, giving Australia a high profile in the quest to understand the universe. When applied to everyday ....Digital Interferometry: A platform technology for robust optical measurements. Digital interferometry is a new concept which will allow the measurement precision of interferometry to be applied in otherwise inaccessible or unsuitable environments. It will enhance the performance of major scientific instruments, such as gravitational wave detectors and optical telescopes, whilst reducing the cost, giving Australia a high profile in the quest to understand the universe. When applied to everyday situations, such as surveillance, traffic flow or vibration monitoring, it can give Australian industry a economic and social advantage, increasing the wealth and security of the nation. Read moreRead less
Exposure dating with manganese-53, neon-21 and beryllium-10: a new toolkit for studying long-term landscape evolution. Australia today is the driest inhabited continent but this was not always the case. Tens of millions of years ago the climate of Australia was considerably wetter. Then, several million years ago, aridity in Australia developed producing most of the desert features of the red Centre that we see today. The age of our deserts and other arid features are not, however, well known. T ....Exposure dating with manganese-53, neon-21 and beryllium-10: a new toolkit for studying long-term landscape evolution. Australia today is the driest inhabited continent but this was not always the case. Tens of millions of years ago the climate of Australia was considerably wetter. Then, several million years ago, aridity in Australia developed producing most of the desert features of the red Centre that we see today. The age of our deserts and other arid features are not, however, well known. This project will determine the age of desertification in Australia, thereby enhancing our understanding of such processes and the response of our landscape to changing climate.
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Global Gravitational Wave Astronomy. To listen to the universe with gravitational waves needs a global array of gravitational wave observatories, and one of these must be in the southern hemisphere - in Australia. By definitively answering outstanding questions about an Australian gravitational wave observatory - Where should it be? How sensitive? What astronomy will it aid? - we make the case for the international community to help build this observatory, investing hundreds of millions of dolla ....Global Gravitational Wave Astronomy. To listen to the universe with gravitational waves needs a global array of gravitational wave observatories, and one of these must be in the southern hemisphere - in Australia. By definitively answering outstanding questions about an Australian gravitational wave observatory - Where should it be? How sensitive? What astronomy will it aid? - we make the case for the international community to help build this observatory, investing hundreds of millions of dollars in rural Australia and keeping Australia on the cutting edge of all branches of astronomy. As a flagship client of advanced data GRID technologies, we will also shape the growth of Australian knowledge of, and infrastructure for, next-generation communications technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346876
Funder
Australian Research Council
Funding Amount
$1,584,000.00
Summary
800 MHz NMR Spectrometer for Molecular Structure-Function Analyses. An 800 MHz high-resolution nuclear magnetic resonance (NMR) spectrometer equipped with a triple-resonance cryoprobe is required to support the research of 5 universities in the NSW/ACT area. The high magnetic field of the spectrometer is necessary for the study of proteins, protein-ligand complexes and other biomolecular systems of molecular weight >30,000. Projects previously inaccessible due to sensitivity, solubility or resol ....800 MHz NMR Spectrometer for Molecular Structure-Function Analyses. An 800 MHz high-resolution nuclear magnetic resonance (NMR) spectrometer equipped with a triple-resonance cryoprobe is required to support the research of 5 universities in the NSW/ACT area. The high magnetic field of the spectrometer is necessary for the study of proteins, protein-ligand complexes and other biomolecular systems of molecular weight >30,000. Projects previously inaccessible due to sensitivity, solubility or resolution problems will become tractable. The increased turn-around times afforded by the high sensitivity of the cryo-enabled spectrometer make it possible to provide access for Australian institutions that would not otherwise have access to comparable equipment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775546
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Construction of the blue-arm of the ANU 2.3m telescope Wide-Field Spectrograph. The new blue and red arms of the WiFeS spectrograph on the SSO 2.3m telescope utilizes new optical techniques and advances in detector technology to provide unique capabilities for front-line research and student training. The novel integral field units on WiFeS extract spectra across the face of faint, distant galaxies enabling the dynamics of the stellar and gas content to be analysed in unprecedented detail. Anoth ....Construction of the blue-arm of the ANU 2.3m telescope Wide-Field Spectrograph. The new blue and red arms of the WiFeS spectrograph on the SSO 2.3m telescope utilizes new optical techniques and advances in detector technology to provide unique capabilities for front-line research and student training. The novel integral field units on WiFeS extract spectra across the face of faint, distant galaxies enabling the dynamics of the stellar and gas content to be analysed in unprecedented detail. Another important project will be to follow-up interesting objects discovered by the new SkyMapper telescope and establish those that need to be observed on 8 m telescopes such as Gemini, Magellan or VLT. Read moreRead less