Electric field induced surface attachment and detachment of proteins. Microarrays are revolutionising the diagnosis of disease by enabling large amounts of data on genetics and protein expression to be obtained from one sample. Biosensors for diseases and toxins rely on the same mechanism, namely attachment of biological macromolecules to a surface. We propose a new method for controlling the attachment by micromachining an electrode system to apply an electric field to chosen sites. Ultimately ....Electric field induced surface attachment and detachment of proteins. Microarrays are revolutionising the diagnosis of disease by enabling large amounts of data on genetics and protein expression to be obtained from one sample. Biosensors for diseases and toxins rely on the same mechanism, namely attachment of biological macromolecules to a surface. We propose a new method for controlling the attachment by micromachining an electrode system to apply an electric field to chosen sites. Ultimately microelectronic engineering methods will be used. This will give control over the attachment process with potential benefits of orienting attaching molecules, minimising non-specific attachment and enriching diagnostics by enabling interrogation of the force of attachment.Read moreRead less
Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzy ....Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzymatic reactions through which the analyte will convert to much simpler, reactive and hence measurable molecules. This project will enable to design miniaturised sensors for point-of-care detection of biomolecules that cannot be yet evaluated by the end users.Read moreRead less
Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Austral ....Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Australian research is at the forefront in steel and composite structures, and this project will strengthen Australia's positioning in the discipline by developing transparent design and assessment procedures from an efficient algorithm that delivers hands-on guidance for engineering practitioners.Read moreRead less
Amplifying light emission with metal-fluorophore nanostructures for ultrasensitive biosensing. This proposal focuses on translating nanotechnology to ultrasensitive molecular monitoring for biomedicine. We will apply a new tool, amplified fluorophores to proteomics where they will provide an improved method for early detection and understanding of diseases through molecular fingerprints. The project will also generate an ultra-sensitive, rapid technology that can be used for personalized point ....Amplifying light emission with metal-fluorophore nanostructures for ultrasensitive biosensing. This proposal focuses on translating nanotechnology to ultrasensitive molecular monitoring for biomedicine. We will apply a new tool, amplified fluorophores to proteomics where they will provide an improved method for early detection and understanding of diseases through molecular fingerprints. The project will also generate an ultra-sensitive, rapid technology that can be used for personalized point-of-care diagnostics. The applications can include the detection of disease markers, pathogens or the determination of protein content in a clinical sample. These technologies will be applicable across a spectrum or of diseases all of which will benefit the broader community.Read moreRead less
Exploiting the self-assembly of hydrophobin proteins to engineer functional nanostructuring surfaces. There is an increasing world-wide demand for advanced nano-biomaterials with novel properties. We will use natural hydrophobin proteins to coat nanodevices and make them more compatible with biological systems. Hydrophobin coatings will be applicable to biosensors, medical devices, diagnostics and drug delivery systems. The research will lead to an understanding of the basic mechanisms of protei ....Exploiting the self-assembly of hydrophobin proteins to engineer functional nanostructuring surfaces. There is an increasing world-wide demand for advanced nano-biomaterials with novel properties. We will use natural hydrophobin proteins to coat nanodevices and make them more compatible with biological systems. Hydrophobin coatings will be applicable to biosensors, medical devices, diagnostics and drug delivery systems. The research will lead to an understanding of the basic mechanisms of protein self-assembly and will have application outcomes that contribute to Australia being an important player in the field of nanotechnology. This is critical for Australia's long term competitiveness and productivity in and beyond the 21st century.Read moreRead less
A Programming Model of Object Validity for Secure and Efficient Concurrency. To provide improved performance and security for software applications, Australia's ICT industry must adapt to the complex programming demands of modern multicore processors. The programming model developed in the project represents a breakthrough solution. A seamless integration of concurrency and object orientation leads to a simple yet powerful programming style that is compatible with today's premier approach to bui ....A Programming Model of Object Validity for Secure and Efficient Concurrency. To provide improved performance and security for software applications, Australia's ICT industry must adapt to the complex programming demands of modern multicore processors. The programming model developed in the project represents a breakthrough solution. A seamless integration of concurrency and object orientation leads to a simple yet powerful programming style that is compatible with today's premier approach to building large-scale software systems with significantly improved performance and security. The product will reduce development time for compute-intensive applications in many industry sectors, including health care (e.g. patient monitoring), finance, defence, environment, mining, manufacturing and computer games.Read moreRead less
Analysis and Optimisation of Incomplete Object-Oriented Programs. This project will push Australia to the forefront of OO technologies and will increase the profile of advanced programming language design and implementation research in Australia. The completed framework will
likely be commercially viable as Australia industries such as banks and
insurance companies and government organisations hosting large
OO software systems may benefit (in terms of performance and
code security) from the ....Analysis and Optimisation of Incomplete Object-Oriented Programs. This project will push Australia to the forefront of OO technologies and will increase the profile of advanced programming language design and implementation research in Australia. The completed framework will
likely be commercially viable as Australia industries such as banks and
insurance companies and government organisations hosting large
OO software systems may benefit (in terms of performance and
code security) from the technology developed as a result of this research. The completed framework will also provide an excellent platform for researchers in Australia and elsewhere to do research in OO technologies, helping in producing quality students for the Australian IT industry.Read moreRead less
Scratchpad-based Memory Allocation Techniques for Embedded Software. This research aims at developing automatic memory allocation algorithms to maximise the effective utilisation of scratchpad memories, which will lead to significantly improved performance and energy usage in embedded applications. The outcomes of this project will provide generic solutions to many Australia-based industries, including telecommunication, network management, sensor networks, automotive and instrumentation/measure ....Scratchpad-based Memory Allocation Techniques for Embedded Software. This research aims at developing automatic memory allocation algorithms to maximise the effective utilisation of scratchpad memories, which will lead to significantly improved performance and energy usage in embedded applications. The outcomes of this project will provide generic solutions to many Australia-based industries, including telecommunication, network management, sensor networks, automotive and instrumentation/measurement, where embedded systems are ubiquitously used. Therefore, this project will significantly contribute to the Priority Area (Frontier Technologies for Building and Transforming Australian Industries), hence fits into its Priority Goal: Frontier Technologies.Read moreRead less
Compiler-Directed Code Tiling for Higher Program Performance and Predictability on Multi-Level Memory Hierarchies. Programming languages invariably induce a perception of memory as being flat, whereas actual computers are being equipped increasingly with deep memory hierarchies to overcome the ever-widening performance gap between processors and memories. This mismatch can result in low locality of reference and poor performance. This project will develop a new array layout transformation, calle ....Compiler-Directed Code Tiling for Higher Program Performance and Predictability on Multi-Level Memory Hierarchies. Programming languages invariably induce a perception of memory as being flat, whereas actual computers are being equipped increasingly with deep memory hierarchies to overcome the ever-widening performance gap between processors and memories. This mismatch can result in low locality of reference and poor performance. This project will develop a new array layout transformation, called data tiling, used in tandem with loop tiling to achieve significantly improved performance gains (and predictability) for array-dominated applications on multi-level memory hierarchies. We will explore this joint restructuring to obtain higher performance and predictability for whole programs, kernel libraries, iterative stencil codes and embedded applications.
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Genetics and evolution of Shigella O antigens. We use genome scale sequencing techniques to sequence 26 O-antigen gene clusters from Shigella. With the seven already known, this will give sequences for every O-antigen of Shigella. This will be the first time that such set is fully sequenced. Shigella are human specific pathogens, have emerged with the evolution of humans. O-antigens are important for their life and pathogenicity. This project will greatly extend our knowledge of the genetic basi ....Genetics and evolution of Shigella O antigens. We use genome scale sequencing techniques to sequence 26 O-antigen gene clusters from Shigella. With the seven already known, this will give sequences for every O-antigen of Shigella. This will be the first time that such set is fully sequenced. Shigella are human specific pathogens, have emerged with the evolution of humans. O-antigens are important for their life and pathogenicity. This project will greatly extend our knowledge of the genetic basis and evolution of this important polymorphism. O-antigens are used for typing Shigella and also elicit strong immunity. The molecular data will help establish DNA based typing and vaccine development.Read moreRead less