Improving dairy cow fertility: targeting exosome-responsive cell pathways. . This project aims to assist the dairy industry to achieve its goal of increasing the six-week in-calf pregnancy rate in dairy cows by at least 10 per cent within five years via the identification of circulating exosomal biomarkers of improved fertility that will be used to develop superior breeding stock to deliver higher industry productivity. The impact of novel biomarkers will permit the Australian and New Zealand da ....Improving dairy cow fertility: targeting exosome-responsive cell pathways. . This project aims to assist the dairy industry to achieve its goal of increasing the six-week in-calf pregnancy rate in dairy cows by at least 10 per cent within five years via the identification of circulating exosomal biomarkers of improved fertility that will be used to develop superior breeding stock to deliver higher industry productivity. The impact of novel biomarkers will permit the Australian and New Zealand dairy industries to meet their targets and provide economic benefit to the respective industries, whilst ensuring availability of low cost milk to Australian citizens.Read moreRead less
Epigenetic and biomarker approaches to improving dairy cow fertility. The dairy industry will not deliver sustainable higher productivity unless the reproductive performance of dairy cows is significantly improved. This expected outcome will be achieved via the identification of epigenetic and protein biomarkers of improved fertility that will be used to develop superior breeding stock. Caruncular and intercaruncular tissues and blood have been obtained from both fertile (New Zealand Holstein-Fr ....Epigenetic and biomarker approaches to improving dairy cow fertility. The dairy industry will not deliver sustainable higher productivity unless the reproductive performance of dairy cows is significantly improved. This expected outcome will be achieved via the identification of epigenetic and protein biomarkers of improved fertility that will be used to develop superior breeding stock. Caruncular and intercaruncular tissues and blood have been obtained from both fertile (New Zealand Holstein-Friesian) and sub-fertile (North American Holstein-Friesian) cows within pasture-based dairying systems that include seasonal calving and subclinical uterine inflammation (associated with poor reproductive performance). Determinations will be conducted using deep parallel (next generation) sequencing and mass spectrometry.Read moreRead less