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Prognostic Markers Of Cardiovascular Risk In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$104,132.00
Summary
One in three Australians are at risk of chronic kidney disease; however, these patients are more likely to die of heart disease. There is a need to identify markers in kidney failure patients to detect heart disease early. Unmasking cardiac risk factors by using change in cardiac biomarkers and echocardiographic parameters with exercise is novel. This will help the physician to diagnose _subclinical� cardiovascular dysfunction early, hence preventing cardiovascular mortality by institution of ap ....One in three Australians are at risk of chronic kidney disease; however, these patients are more likely to die of heart disease. There is a need to identify markers in kidney failure patients to detect heart disease early. Unmasking cardiac risk factors by using change in cardiac biomarkers and echocardiographic parameters with exercise is novel. This will help the physician to diagnose _subclinical� cardiovascular dysfunction early, hence preventing cardiovascular mortality by institution of appropriate therapies.Read moreRead less
The Role Of The Clotting Cascade In Aortic Aneurysm And Associated Cardiovascular Events
Funder
National Health and Medical Research Council
Funding Amount
$651,173.00
Summary
Weakening of the main abdominal artery is responsible for approximately 1000 deaths/ year in Australia. Most weakened arteries are identified at an early stage but there is no current therapy which limits the progression of artery weakening. There is also no model which predicts the complications associated with weakened arteries. In the current project we propose the importance of clot in progression and complications of weakened arteries. We will undertake studies to identify new therapies and ....Weakening of the main abdominal artery is responsible for approximately 1000 deaths/ year in Australia. Most weakened arteries are identified at an early stage but there is no current therapy which limits the progression of artery weakening. There is also no model which predicts the complications associated with weakened arteries. In the current project we propose the importance of clot in progression and complications of weakened arteries. We will undertake studies to identify new therapies and a predictive model for weakened arteries.Read moreRead less
Centre Of Excellence For Clinical Research Training In Translational Cardiology
Funder
National Health and Medical Research Council
Funding Amount
$2,622,253.00
Summary
We aim to convert novel scientific findings to better treating patients with end-stage heart disease. A secondary aim is to train clinicians with a better understanding of sophisticated scientific approaches so they can better transfer this knowledge to health practices and policies. We will study new ways of identifying patients who are likely to suffer from heart attacks as well as those with heart problems who appear to function well but in fact have poor health and life outlook.
Key Role Of Connective Tissue Growth Factor (CTGF) In Familial Cardiomyopathy And Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$395,051.00
Summary
Familial cardiomyopathies are an important cause of heart failure and sudden death. Understanding the precise mechanisms of how disease develops in cardiomyopathies is an important step for developing new therapeutic and prevention strategies. We plan to investigate the role of connective tissue growth factor (CTGF) , an important protein which causes scar formation in the heart, in cells, mice, and humans predisposed to developing heart disease.
UNLOCKING GENETIC FACTORS PREDICTING TYPE 2 DIABETES COMPLICATIONS FOR CLINICAL PRACTICE: THE FIELD STUDY
Funder
National Health and Medical Research Council
Funding Amount
$2,503,122.00
Summary
Heart disease, stroke, eye and kidney diseases in diabetes have both environmental and genetic predispositions. With over 5000 Australians with diabetes, this research in the FIELD study is to identify the important genetic contributors to these complications. It will explore how the genetic features cause disease and whether the most important ones can be screened for in simple blood tests. It will also examine whether the genetic damage of ageing is accelerated in diabetes.
A Non-invasive Fluid Status Monitoring Device For Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$360,715.00
Summary
Both acute decompensated heart failure (ADHF) and chronic kidney disease (CKD) are characterised by fluid overload. A device to detect this fluid overload in patients at an early stage has the potential to reduce the need for hospitalisation and initiate more timely and aggressive intervention. A prototype device has already been developed and our aim is to further improve on this device and advance to a commercial product.
The Role Of Oxidative Processes In Atherosclerosis And Related Diseases
Funder
National Health and Medical Research Council
Funding Amount
$966,135.00
Summary
Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings in ....Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings into novel therapeutics and diagnostics.Read moreRead less
A Randomized Comparison Evaluating The Value Of High-sensitivity Troponin In The Efficient Management Of Chest Pain Patients Across The Spectrum Of Risk For An Acute Coronary Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$508,567.00
Summary
Chest pain patients are a large burden of emergency department demand. Their effective care requires timely risk assessment. High-sensitivity assays for cardiac muscle damage (troponin) increases the ability to detect patients with heart attacks, but may also lead to more abnormal results from other causes and more admissions. This randomized trial of current troponin versus a new troponin assays with robust initial evaluation of patient risk will provide a rationale for their use in modern care ....Chest pain patients are a large burden of emergency department demand. Their effective care requires timely risk assessment. High-sensitivity assays for cardiac muscle damage (troponin) increases the ability to detect patients with heart attacks, but may also lead to more abnormal results from other causes and more admissions. This randomized trial of current troponin versus a new troponin assays with robust initial evaluation of patient risk will provide a rationale for their use in modern care.Read moreRead less