Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social ....Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social benefits for patients, their families, hospitals and their staff, governments and healthcare organisations could thus result. The developed technology would be non-invasive, compact and relatively inexpensive, and could thus be used in rural and regional hospitals, thereby also benefiting patients in those communities. Read moreRead less
My research team is focused on human parasites of major relevance to the Australian water industry and/or global public health. Our primary focus is the use of advanced technologies to improve understanding of these parasites and to utilize this information to underpin development of new drugs to treat them and novel diagnostic tests to improve their control.
I am a virologist exploiting basic and applied research on hepatitis viruses to develop biotechnology innovations in diagnostics and vaccines for a broad range of infectious diseases
Micropapillary Adenocarcinoma: The Emergence Of A Discrete Lung Cancer Phenotype And Its Genomic And Transcriptomic Characterization.
Funder
National Health and Medical Research Council
Funding Amount
$117,565.00
Summary
I believe I can describe a new subtype of lung cancer, which has never been classified by the World Health Organization. This has been previously mis-classified or simply ignored. My hypothesis is that this is a distinct disease by virtue of patterns of genetic abnormalities as well as features visible under the microscope. I also believe it is one of the most aggressive cancers and needs new treatments.
Over the next five years, I will further expand and continue to translate my basic and clinical research programs in women’s health to deliver outcomes to the Australian and international health care systems. In particular, I will target the concept of pregnancy as a determinant of future community health and wellbeing. There is now substantial consensus that environmental influences (including, but not limited to, maternal nutrition) during early life can have a fundamental impact on human deve ....Over the next five years, I will further expand and continue to translate my basic and clinical research programs in women’s health to deliver outcomes to the Australian and international health care systems. In particular, I will target the concept of pregnancy as a determinant of future community health and wellbeing. There is now substantial consensus that environmental influences (including, but not limited to, maternal nutrition) during early life can have a fundamental impact on human development, with consequences for biological and social function and behaviour throughout the lifecourseRead moreRead less
The Role Of Oxidative Processes In Atherosclerosis And Related Diseases
Funder
National Health and Medical Research Council
Funding Amount
$966,135.00
Summary
Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings in ....Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings into novel therapeutics and diagnostics.Read moreRead less
Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that op ....Smart Information Use for PET-CT Quantitative Molecular Imaging. This project aims to use advanced computing algorithms to tackle
challenging problems associated with a new medical technology called
PET-CT which combines two imaging modalities in one device. While this technology is very new and has great potential in cancer and brain disorders, it also poses major challenges for information processing and transmission. We will address these challenges by developing advanced algorithms that optimally extract information from PET and CT using mathematical models that correct for the various sources of inaccuracy. Our research will put Australian biomedical researchers and healthcare professionals at the forefront of advanced medical imaging technology.Read moreRead less
An Innovative Multimedia Framework for Multidimensional PET-CT Image Navigation and Communication. The recent development of a combined positron emission tomography and computerized tomography (PET-CT) device ushers in a completely new era in molecular imaging that will revolutionize the approach to imaging in the clinical environment. In this project, we address a number of the critical challenges associated with the introduction of PET-CT, and provide a range of innovative multimedia technolo ....An Innovative Multimedia Framework for Multidimensional PET-CT Image Navigation and Communication. The recent development of a combined positron emission tomography and computerized tomography (PET-CT) device ushers in a completely new era in molecular imaging that will revolutionize the approach to imaging in the clinical environment. In this project, we address a number of the critical challenges associated with the introduction of PET-CT, and provide a range of innovative multimedia technologies to visualize, manipulate and deliver these multi-dimensional data. Our research will greatly enhance the clinical and research benefits of PET-CT and facilitate new discoveries which will have a significant scientific and social impact in Australia and the world at large.Read moreRead less
Antibiotic resistance increases mortality and costs in the Intensive Care Unit (ICU), but the impact of antibiotic therapy has not been adequately studied. We propose to characterise the behaviour of key elements of the bacterial microflora (resistant bacteria and major resistance genes) in response to antibiotics. We have developed new rapid diagnostics to harness these data and this proposal has the potential to greatly improve diagnostic speed and accuracy and thus clinical outcomes.