Exploring The Occurrence And Potential Associated Risk Factors For Pilchard Orthomyxovirus (POMV) In Tasmanian Farmed Atlantic Salmon
Funder
Fisheries Research and Development Corporation
Funding Amount
$209,295.62
Summary
Following basic epidemiology principles, no infectious disease occurs ‘randomly’ and its occurrence follow logical and predictable patterns. The presence of an infectious agent is unlikely sufficient to explain these patterns and most aquatic diseases result from the complex interaction between the agent, the host and its environment. Therefore, the targeted outcome for a POMV control plan is threefold: 1. Decrease transmission between infected and susceptible fish groups – this requires ide ....Following basic epidemiology principles, no infectious disease occurs ‘randomly’ and its occurrence follow logical and predictable patterns. The presence of an infectious agent is unlikely sufficient to explain these patterns and most aquatic diseases result from the complex interaction between the agent, the host and its environment. Therefore, the targeted outcome for a POMV control plan is threefold: 1. Decrease transmission between infected and susceptible fish groups – this requires identifying risk factors associated with the introduction, spread, and maintenance of the pathogen within the industry; 2. Decrease the number of susceptible fish – this mainly requires identifying risk factors associated with the susceptibility of the host (e.g. husbandry-related stress) and the development of a safe and effective prophylaxis; 3. Decrease the amount of virus in the environment - this requires detecting infected fish cage(s) early to implement timely control strategies. Diagnostic capacity to confirmed POMV outbreak has been developed and is currently used in routine by the industry. A vaccine against POMV is currently under development at the Tasmanian Aquatic Animal Health and Vaccines Centre of Excellence and will be available in the future. However, little is known about risk factors specific to POMV and about its full economic impact. We define as a ‘risk factor’ any attribute of the agent, the host or its environment that increases the risk and intensity of a disease outbreak. Most of the environmental risk factors (including farming practices) facilitate the introduction, transmission, or maintenance of the pathogen; while the host risk factors affect the susceptibility of the host and its capacity to become diseased. Like the closely related ISAv, the magnitude and occurrence of POMV outbreaks appeared to be highly variable. This supports the existence of additional factors other than the POMV infection that contribute to the intensity of an outbreak. It is anticipated that by identifying and intervening on some of the manageable risk factors, the frequency and the severity of POMV outbreaks can be reduced. Objectives: 1. Describe the occurrence of POMV outbreaks in the Tasmanian salmon industry 2. Quantify the direct financial impact of POMV mortality to the Tasmanian salmon industry 3. Identify potential management, environmental and stock risk factors directly or indirectly increasing the risk and intensity of a POMV outbreaks Read moreRead less
A new look at perceptual expertise: the attentional Gestalt framework. This project aims to propose and rigorously test a new, mechanistic framework for understanding how training and experience alters our capacity to perceive and engage in skilled visual processing. The project intends to explain why trained visual experts often rapidly perceive things that elude novices. Expected outcomes of the project include new knowledge about the key mechanistic features that underlie skilled visual perfo ....A new look at perceptual expertise: the attentional Gestalt framework. This project aims to propose and rigorously test a new, mechanistic framework for understanding how training and experience alters our capacity to perceive and engage in skilled visual processing. The project intends to explain why trained visual experts often rapidly perceive things that elude novices. Expected outcomes of the project include new knowledge about the key mechanistic features that underlie skilled visual performance. Intended benefits of this knowledge include the development of artificial systems and improved training environments to facilitate and enhance human expert visual processing.Read moreRead less
Aquatic Animal Health And Biosecurity Coordination Program: Strategic Planning, Project Management And Adoption
Funder
Fisheries Research and Development Corporation
Funding Amount
$605,748.56
Summary
Australia’s aquatic animals are free from many diseases that occur overseas, providing us with a competitive advantage in both production and trade. Australian aquaculture has grown from an industry valued at AU$260 million in 1993 to an industry valued at AU$1.6 billion in 2020 (ABARES, 2021). This dramatic growth has been accompanied by the emergence of new diseases/infectious agents, e.g., NNV since 1989, Bonamia since 1992, OOD since 2006, OsHV since 2010, POMV since 2012, new YHV genotypes ....Australia’s aquatic animals are free from many diseases that occur overseas, providing us with a competitive advantage in both production and trade. Australian aquaculture has grown from an industry valued at AU$260 million in 1993 to an industry valued at AU$1.6 billion in 2020 (ABARES, 2021). This dramatic growth has been accompanied by the emergence of new diseases/infectious agents, e.g., NNV since 1989, Bonamia since 1992, OOD since 2006, OsHV since 2010, POMV since 2012, new YHV genotypes since 2013, PMMS since 2015 and WSD since 2016, all of which threaten the sustainability of major aquaculture enterprises. Consequently, the need for health research to support this expanding sector is also growing. The wild-harvest, recreational, Indigenous and ornamental sectors are also under threat; e.g., crayfish plague, Edwardsiella ictaluri in catfish, Perkinsus in oysters, WSD in crustacea and gourami iridovirus in a range of finfish species pose significant risks.
Thus, identification and prioritisation of aquatic animal health and biosecurity research and capacity building needs to be coordinated across all aquatic sectors to ensure synergy while avoiding duplication. FRDC, through AAHBRCP, plays a major role in addressing research needs and training in aquatic animal health and biosecurity and is able to direct funding priorities to the most pressing areas. AAHBRCP provides a cohesive national approach to FRDC-supported R&D by providing leadership, direction and focus for health R&D and other related non-R&D activities. According to an external review of AAHBRCP undertaken in 2015 the consensus among major stakeholders was that AAHBRCP provides an essential service for the aquatic animal sector. Given the success of the AAHBRCP there is a need to continue it as a means of providing the service with consideration given to adjustments (reflected in this proposal) to enhance the service it provides for the evolving needs of Australia’s seafood industry, public policy and program needs
Objectives: 1. In consultation with key stakeholders (industry, government, aquatic animal health providers and industry representatives) identify and prioritise R&D needed to deliver national, jurisdictional and industry sector aquatic animal health and biosecurity related planning objectives 2. Promote and manage aquatic animal health and biosecurity training and capacity building 3. Facilitate the dissemination of outputs (information and results) from R&D projects to key stakeholders 4. Through the biannual AAHBRCP scientific conference, cultivate research community collaboration, engagement, and foster early career researchers. Read moreRead less
Development Of Molecular Detection Methods For Myxosporean Parasites Infecting Yellowtail Kingfish And Mahi Mahi
Funder
Fisheries Research and Development Corporation
Funding Amount
$393,002.00
Summary
Soft flesh due to infection with myxosporean parasites irreversibly reduces the quality and market value of fish. Due to the delayed onset of the condition, infected fish can reach the consumer before soft flesh is detected, causing wastage, economic losses to affected fishers, and loss of consumer confidence.
Rapid onsite detection of myxosporean infection is vital to maximise value of landed fish, minimise environmental impacts associated with animal protein wastage, and increase prod ....Soft flesh due to infection with myxosporean parasites irreversibly reduces the quality and market value of fish. Due to the delayed onset of the condition, infected fish can reach the consumer before soft flesh is detected, causing wastage, economic losses to affected fishers, and loss of consumer confidence.
Rapid onsite detection of myxosporean infection is vital to maximise value of landed fish, minimise environmental impacts associated with animal protein wastage, and increase productivity for NSW commercial fishers, NSW fishers cooperatives and relevant fish markets.
This project focuses on outcome 2 of FRDC’s R&D plan – best practices and production systems. Fast and accurate detection of pathogens help industry identify risks faster and make informed decisions to refine and optimise best practices and production systems. There will be several benefits and impacts on society, environment, and the economy, including:
Society - fisheries productivity affects livelihoods of people working in the industry and its associated sectors - healthy and sustainable food resources Environment - reduce wastage Economic - increasing productivity through higher yields and higher market value - enhancing food/protein production improves food security and creates more employment opportunities Objectives: 1. To develop and evaluate PCR-based diagnostic tools for quantitative detection of myxosporeans in Mahi Mahi and Yellowtail Kingfish 2. To develop and evaluate in situ diagnostic tools for quantitative detection of myxosporeans in Mahi Mahi and Yellowtail Kingfish Read moreRead less
Assess The Future Needs Of Australia's Aquatic Animal Disease Diagnostic System
Funder
Fisheries Research and Development Corporation
Funding Amount
$342,866.00
Summary
Global and domestic trends in aquatic animal production and trade indicate that Australia will increasingly require agile, strong, and modern diagnostic systems to effectively manage disease risks (AQUAPLAN, 2022). To strengthen and support the aquatic animal diagnostic network we need to thoroughly understand future industry needs – which are rapidly evolving.
This project seeks to forecast diagnostic needs and understand the changing demands for aquatic animal health diagnostic servi ....Global and domestic trends in aquatic animal production and trade indicate that Australia will increasingly require agile, strong, and modern diagnostic systems to effectively manage disease risks (AQUAPLAN, 2022). To strengthen and support the aquatic animal diagnostic network we need to thoroughly understand future industry needs – which are rapidly evolving.
This project seeks to forecast diagnostic needs and understand the changing demands for aquatic animal health diagnostic services in Australia. For example, activities such as the safe translocation of stock between states, the establishment of specific pathogen free (SPF) broodstock, point-of-care-testing, emerging production diseases and increasing requirements from trading partners, will all require robust diagnostic technologies that are reliable, fit-for-purpose and accessible within the diagnostic network.
To forecast diagnostic requirements, we propose the following key activities, including a workshop (if required). The workshop is a STOP-GO point in our project and the decision to go ahead will be established in consultation with a project Steering Committee. The main activities in this project include:
1. Establishment of a Steering Committee and Terms of Reference to assist with milestone reporting and project oversight.
2. Generation of a map of the current operators and regulators of the diagnostic network for aquatic animal health in Australia.
3. Stakeholder consultation. This will be conducted incrementally through key informant interviews with the following stakeholder groups:
I. Stage 1. Members of SCAAH representing each State and Territory to identity their future needs, and further key informants. II. Stage 2A. Diagnostic service providers (Government and private veterinary laboratories identified by SCAAH) to provide insight into current diagnostic services capabilities/capacity and identify future needs. III. Stage 2B. End-users of the diagnostic network and regulators (identified by SCAAH and the research team) to provide insight into current diagnostic needs and challenges and identify future needs.
4. Scoping review of existing and novel diagnostic technologies relevant to aquatic animal health (to be conducted in parallel to the stakeholder consultation process).
5. A workshop (STOP-GO point) with key stakeholders to discuss specific needs identified in Activity 3
6. A Final Report presenting a roadmap to guide the implementation and adoption of future diagnostic needs.
Our final report and roadmap will inform priority areas for investment in the diagnostic system and provide advice to regulators. Areas for investment could include additional research and development, and upskilling of veterinary practitioners and laboratory diagnosticians. A schematic diagram of the project proposal is presented in the Appendix.
As per AQUAPLAN’s vision, this project is an exceptional opportunity to bring together a network of collaborators across multiple disciplines and sectors to support sustainable industry growth. Objectives: 1. Undertake stakeholder consultation to inform future demands on the diagnostic system over the next 5 to 10 years considering the current diagnostic landscape, and the emergence of new diagnostic needs and technologies. Read moreRead less
Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary ....Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.Read moreRead less
Systems-based Study, Intervention, Diagnosis And Control Of Gastrointestinal Parasites
Funder
National Health and Medical Research Council
Funding Amount
$2,538,220.00
Summary
Gastrointestinal parasites cause billions of infections and hundreds of thousand of deaths globally each year. Even in developed countries, these parasites remain an important public health risk, through the cost of their control, the acute impacts of infection and their contribution to post-infectious irritable bowel syndrome and chronic fatigue. My team employs cutting-edge methods to improve their diagnosis, surveillance, treatment and control.
Inverse problems with partial data. This project aims to use mathematics, in particular the theory of micro-local analysis, to determine the amount of measurements one needs in order to reconstruct an image by some of the tomography methods commonly used in medical imaging. Expected outcomes of this project include showing that an arbitrarily small set of boundary measurements is sufficient to reconstruct the coefficients of various important partial differential equations such as Schrodinger eq ....Inverse problems with partial data. This project aims to use mathematics, in particular the theory of micro-local analysis, to determine the amount of measurements one needs in order to reconstruct an image by some of the tomography methods commonly used in medical imaging. Expected outcomes of this project include showing that an arbitrarily small set of boundary measurements is sufficient to reconstruct the coefficients of various important partial differential equations such as Schrodinger equation, Dirac operators, and Maxwell equations. In addition to providing a theoretical foundation upon which one can build numerical algorithms, this project will also provide the missing link between inverse problems and unique continuation theory. The downstream impact of this research will lead to more efficient and accurate tomography methods which can be implemented in a range of imaging applications.Read moreRead less
Bioinks that Advance 3D bioprinting of cells to the 4th dimension. The aim of this research is to provide a simple method for creating complex 3D cell cultures for in vitro cell based assays using 3D printing. A versatile polymer system as a bioink made from entirely commercially available components, will be advanced that gives a full range of soft tissue mimics and which can be dynamically change on-demand after printing of the 3D cell cultures. The latter will provide in vitro mimics of in vi ....Bioinks that Advance 3D bioprinting of cells to the 4th dimension. The aim of this research is to provide a simple method for creating complex 3D cell cultures for in vitro cell based assays using 3D printing. A versatile polymer system as a bioink made from entirely commercially available components, will be advanced that gives a full range of soft tissue mimics and which can be dynamically change on-demand after printing of the 3D cell cultures. The latter will provide in vitro mimics of in vivo events never previously possible with more realistic models of what is found in vivo. Applications are in fundamental cell biology, studying diseases and developing new drugs. The outcomes from this research will be new knowledge on designing cheap extracellular matrix mimics and high throughout 3D cell assays.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less