Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453920
Funder
Australian Research Council
Funding Amount
$108,680.00
Summary
Molecular diagnostics based on real-time polymerase chain reactions for emerging tropical infectious diseases aimed at protecting Australia from invasive diseases. The project aims to use the technique of real-time polymerase chain reaction to rapidly detect and quantify the organisms associated with emerging and re-emerging infectious diseases of man and animals. It will also be used to determine related gene expression.
The equipment will be used to support a wide range of projects that req ....Molecular diagnostics based on real-time polymerase chain reactions for emerging tropical infectious diseases aimed at protecting Australia from invasive diseases. The project aims to use the technique of real-time polymerase chain reaction to rapidly detect and quantify the organisms associated with emerging and re-emerging infectious diseases of man and animals. It will also be used to determine related gene expression.
The equipment will be used to support a wide range of projects that require the detection of specific RNA or DNA and it will allow the rapid, cost effective and efficient processing of either RNA or DNA from large numbers of samples. Minor variations in organisms will be detected using this equipment.
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Detection and Quantification of General Fetal Movements from Accelerometer Measurements using Nonstationary Signal Processing Techniques. There are approximately 1,750 fetal deaths per year in Australian with about one-third occurring late in gestation and without an apparent cause. The development of an automated system capable of long-term monitoring of fetal health will result in accurate diagnoses and prediction of future outcome. This will, in turn, allow early intervention by the clinicia ....Detection and Quantification of General Fetal Movements from Accelerometer Measurements using Nonstationary Signal Processing Techniques. There are approximately 1,750 fetal deaths per year in Australian with about one-third occurring late in gestation and without an apparent cause. The development of an automated system capable of long-term monitoring of fetal health will result in accurate diagnoses and prediction of future outcome. This will, in turn, allow early intervention by the clinician to reduce fetal deaths and enhance the chances of good outcomes with resultant savings in social and financial costs to the community. The development of such equipment would spawn future research into intervention treatments and contribute to Australia's position as a world leader in computerised health monitoring systems.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH230100013
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Future Digital Manufacturing. This Hub aims to grow and accelerate Australian digital manufacturing (DM) transformation by devising novel DM technology and commercialisation/adoption pathways. The Hub expects to transform industry by developing novel AI and IoT-powered DM technology that provides for dramatic improvement in manufacturing productivity, resilience and competitiveness. Expected outcomes include novel DM technology for digitally representing, predicting, and imp ....ARC Research Hub for Future Digital Manufacturing. This Hub aims to grow and accelerate Australian digital manufacturing (DM) transformation by devising novel DM technology and commercialisation/adoption pathways. The Hub expects to transform industry by developing novel AI and IoT-powered DM technology that provides for dramatic improvement in manufacturing productivity, resilience and competitiveness. Expected outcomes include novel DM technology for digitally representing, predicting, and improving production and its outcomes via an open platform that supports reusing industry co-created DM solutions. Through supporting advanced manufacturing priorities and Industry 4.0, the Hub should provide significant benefits by increasing Australian manufacturing productivity and resilience by 30%.Read moreRead less
Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will he ....Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will help to maintain high research profile of Australian researchers, to increase the capacity for consultancy and contract work, and provide a cutting-edge information technology for the Australian telecommunications industry, business and government (Priority 3 - Frontier Technologies). Read moreRead less
Approximate proximity for applications in data mining and visualization. Data Mining, pattern recognition and visualization of relational information are all important data analysis techniques in which it is essential to determine which data points are in the vicinity of others. The huge size of the data sets involved and the need for real-time interaction preclude the use of conventional methods for the precise computation of the proximity information required. This project will develop efficie ....Approximate proximity for applications in data mining and visualization. Data Mining, pattern recognition and visualization of relational information are all important data analysis techniques in which it is essential to determine which data points are in the vicinity of others. The huge size of the data sets involved and the need for real-time interaction preclude the use of conventional methods for the precise computation of the proximity information required. This project will develop efficient algorithms and data structures for gathering high-quality approximations of the full proximity information, and will use these innovations as the basis for new, practical tools for visualization, and clustering in data mining.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100043
Funder
Australian Research Council
Funding Amount
$435,279.00
Summary
High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super ....High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super-solution imaging of single molecules in live cells. This facility will provide capability for researchers pursuing industry transformation and other initiatives in the development of advanced materials, biomolecular sciences, nanotechnology, photonics and device engineering.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Establishment of Therapeutically Relevant Animal Models and Markers for Crohn's Disease. Crohn's disease is a devastating life long disease, affecting 0.5% of the world population. There is urgent economic and social need to develop new and better drugs to treat the symptoms and underlying cause of this debilitating disease. Social benefits include the improved quality of life of sufferers that positively impacts society. Economic benefit includes income derived from commercialisation of rese ....Establishment of Therapeutically Relevant Animal Models and Markers for Crohn's Disease. Crohn's disease is a devastating life long disease, affecting 0.5% of the world population. There is urgent economic and social need to develop new and better drugs to treat the symptoms and underlying cause of this debilitating disease. Social benefits include the improved quality of life of sufferers that positively impacts society. Economic benefit includes income derived from commercialisation of research outcomes and the contribution this project makes to high value employment in the biotechnology sector.Read moreRead less
Development of Advanced Wear Debris Analysis Techniques for Osteoarthritis Study. Wear and tear of joints is the common cause of osteoarthritis, costing $19.25 billion/year. With this cost on the increase, and no cure to date, comes a need to develop effective methods for its diagnosis. This study will provide new knowledge on osteoarthritis progression by allowing strategic use of national health resources. A fuzzy expert system, to be developed utilising the diagnostic/prognostic techniques of ....Development of Advanced Wear Debris Analysis Techniques for Osteoarthritis Study. Wear and tear of joints is the common cause of osteoarthritis, costing $19.25 billion/year. With this cost on the increase, and no cure to date, comes a need to develop effective methods for its diagnosis. This study will provide new knowledge on osteoarthritis progression by allowing strategic use of national health resources. A fuzzy expert system, to be developed utilising the diagnostic/prognostic techniques of this study will significantly reduce cost and time. The project will contribute to the National Strategy by helping older Australians; the major group of osteoarthritis sufferers, to retain their health, independence and productivity.Read moreRead less