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Using New Retinal Imaging Technologies To Improve Treatment And Classification Of Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$227,644.00
Summary
Diabetic retinopathy is the leading cause of blindness in Australia. This project aims to use new ways of imaging changes in the back of the eye to try to improve the treatment and diagnosis of diabetic retinopathy.
The Genetic And Environmental Risk For Pregnancy Complications And Subsequent Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$350,891.00
Summary
The major problems in late pregnancy are preeclampsia, gestational diabetes and babies who are small or are born prematurely. Women who develop these pregnancy complications and men who father them are at risk of later life coronary heart disease (CHD). The purpose of this study is to develop tests to identify couples at risk of CHD early in pregnancy. If we can predict this risk early, targeted interventions can be implemented to reduce the risk of pregnancy complications and subsequent CHD.
Improving Health Outcomes For Aboriginal And Torres Strait Islander Australians With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$383,684.00
Summary
Based in Darwin, Dr Hughes’ research focuses on improving the health and wellbeing of Aboriginal and Torres Strait Islander peoples at risk of chronic kidney disease (CKD), and those with established Chronic and end-stage kidney disease. These studies focus on participants based in both community and hospital based populations. New areas of clinical research will be addressed, as well as health systems strengthening in both primary and tertiary care systems.
The Influence Of Aqueous And Plasma Cytokines In Treatment Outcomes For Diabetic Macular Oedema
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Diabetic macular oedema (DME) is the commonest cause of central visual loss in diabetics and has been linked to increased levels of vascular endothelial growth factor (VEGF) in the eye. DME is treated with anti-VEGF injections, but these need to be repeated, with some patients failing to respond. We plan to see if levels of VEGF and other inflammatory markers will predict treatment response, so those unlikely to respond can be spared futile treatment and receive alternative treatment earlier.
Exploring Neurological Complications In Animal Models Of Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$337,432.00
Summary
Diabetes causes ongoing damage to the central and peripheral nervous systems. Our research aims to understand the mechanisms of nervous system damage in diabetes by investigating changes in nervous system function overtime in animal models of pre-diabetes, type 2 diabetes and type 1 diabetes. This study specifically aims to utilize indices that can be correlated with measures obtainable in human studies and thereby achieve results with strong clinical relevance and potential for translation.