Identifying The Pathological Mechanism Of PCDH19-Girls Clustering Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$523,988.00
Summary
Changes in the PCDH19 gene are a relatively common cause of epilepsy. To better understand the basis of this disorder, we have developed unique mouse models that mimic the genetic changes and symptoms of this condition. We will perform careful analysis of brain development in these models to determine the primary cause of this condition. These experiments will create greater understanding of how changes in PCDH19 cause epilepsy in girls and facilitate the development of new treatments.
The Transmission Of Perinatal Maternal Mental Health To Preschool Emotional Disorders: Examining Pathways And Intervention Points In The MPEWS Study
Funder
National Health and Medical Research Council
Funding Amount
$970,795.00
Summary
While it is known that depression, anxiety and stress in pregnancy increase the risk for poorer child mental health, what is unknown is the key pathways and intervention points to prevent this transmission of risk. This study will examine potential mechanisms and intervention points through a selected cohort study: Mercy Pregnancy and Emotional Wellbeing Study. This study follows 500 women and their children from first trimester in pregnancy until the children are 3 years of age.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
Evolution of the dermomyotome in vertebrates. The project seeks to understand how different muscle populations within the embryo form and have evolved within the vertebrate phylogeny. All amniote muscles, except that of the head, derive from a transient embryonic structure termed the dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved mechanism that is distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to generate th ....Evolution of the dermomyotome in vertebrates. The project seeks to understand how different muscle populations within the embryo form and have evolved within the vertebrate phylogeny. All amniote muscles, except that of the head, derive from a transient embryonic structure termed the dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved mechanism that is distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to generate the distinct types of locomotor systems we see deployed throughout the vertebrate phylogeny remains unresolved. This project aims to contribute to an understanding of how different locomotor strategies deployed at important evolutionary transitions were generated.Read moreRead less
Motor coordination in infancy and its relationship to motor and psychosocial development in childhood. Few studies have examined the impact of early motor development on later development, even though there is evidence to show that these early movements influence later motor ability. Motor development can also impact on cognitive, emotional and social development. The current study has data on early motor ability in over 90 infants which includes children at risk of developmental disorders. We ....Motor coordination in infancy and its relationship to motor and psychosocial development in childhood. Few studies have examined the impact of early motor development on later development, even though there is evidence to show that these early movements influence later motor ability. Motor development can also impact on cognitive, emotional and social development. The current study has data on early motor ability in over 90 infants which includes children at risk of developmental disorders. We will carry out a longitudinal investigation of the relationship between early motor development in infancy on motor and psychosocial development in childhood. The results will provide information on early markers for developmental disorders and appropriate intervention techniques than can be initiated in infancy. Read moreRead less
Technology is changing the lives of Australians. We need to understand the impact on health to gain the benefits with minimal harm. This fellowship will support a program of internationally leading research drawing together ergonomics, physiotherapy and physical activity expertise. Example projects include the impact of electronic games on children’s activity, walking workstations to increase physical activity of office workers and a family-based program for overweight adolescents.
Protect, prepare and engage: Does extracurricular activity participation offer sustained benefits for youth? Organized extracurricular activities such as sport and music have the potential to promote healthy development and to reduce the levels of risk behaviours in teenagers. However, current research evidence, often based on middle-class youth in the US, is inadequate for making policy recommendations for improvement to the after-school lives of Australian youth. This study will offer insight ....Protect, prepare and engage: Does extracurricular activity participation offer sustained benefits for youth? Organized extracurricular activities such as sport and music have the potential to promote healthy development and to reduce the levels of risk behaviours in teenagers. However, current research evidence, often based on middle-class youth in the US, is inadequate for making policy recommendations for improvement to the after-school lives of Australian youth. This study will offer insight into the long-term benefits of making a diverse selection of organised activities available to Australian teenagers, and will improve our understanding of which aspects of participation are most likely to enhance their social and educational opportunities.Read moreRead less
The Role of Adaptive Coding Mechanisms in the Development of Face Perception. Faces are immensely rich in social information, and early difficulties in extracting such information can have profound consequences for later social functioning. This project will provide insights into the ways in which our face-reading abilities develop throughout childhood. In addition to helping us better understand normal social development, this research will provide a foundation for understanding how face-readi ....The Role of Adaptive Coding Mechanisms in the Development of Face Perception. Faces are immensely rich in social information, and early difficulties in extracting such information can have profound consequences for later social functioning. This project will provide insights into the ways in which our face-reading abilities develop throughout childhood. In addition to helping us better understand normal social development, this research will provide a foundation for understanding how face-reading difficulties can affect people with developmental disorders (such as autism), how face-reading can be disrupted in individuals whose early visual experience is affected by cataracts at birth, and how such difficulties might be alleviated through clinical intervention.Read moreRead less
The role of extracurricular activity participation in promoting healthy development of Australian youth. Organized extracurricular activities such as sport and art have the potential for promoting healthy development and reducing the risks faced by teenagers. However, current research evidence, often based on middle-class youth in the US, is inadequate for making policy recommendations for improvement to the after-school lives of Australian youth. This study will offer insight into the importanc ....The role of extracurricular activity participation in promoting healthy development of Australian youth. Organized extracurricular activities such as sport and art have the potential for promoting healthy development and reducing the risks faced by teenagers. However, current research evidence, often based on middle-class youth in the US, is inadequate for making policy recommendations for improvement to the after-school lives of Australian youth. This study will offer insight into the importance of making a diverse selection of organized activities available to Australian teenagers, and will improve our understanding of which aspects of participation are most likely to enhance their social and educational opportunities.Read moreRead less
The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.