The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Understanding the link between reading impairments and emotional problems. This Project aims to understand why children with reading impairments are at increased risk for emotional problems. By integrating the statistical power of large-scale longitudinal studies with the causal testing power of intervention case studies, it seeks to fast-track the development of a comprehensive evidence-based theory of the mechanisms linking reading impairments and emotional problems. The outcomes will pave the ....Understanding the link between reading impairments and emotional problems. This Project aims to understand why children with reading impairments are at increased risk for emotional problems. By integrating the statistical power of large-scale longitudinal studies with the causal testing power of intervention case studies, it seeks to fast-track the development of a comprehensive evidence-based theory of the mechanisms linking reading impairments and emotional problems. The outcomes will pave the way for future diagnosis and treatment of concomitant reading and emotional difficulties in children. These outcomes improve our capacity to reduce the incidence of two common problems that limit the life success of Australian children - poor literacy and poor emotional health.Read moreRead less
Towards an integrated model of reasoning and reasoning development. This project aims to identify the core cognitive processes that underlie different forms of reasoning and how they develop. The project intends to use a signal detection framework to derive detailed computational models of reasoning which can then be tested through Bayesian computational modelling as well as the first systematic investigation of developmental change in reasoning processes. Expected outcomes include a more princi ....Towards an integrated model of reasoning and reasoning development. This project aims to identify the core cognitive processes that underlie different forms of reasoning and how they develop. The project intends to use a signal detection framework to derive detailed computational models of reasoning which can then be tested through Bayesian computational modelling as well as the first systematic investigation of developmental change in reasoning processes. Expected outcomes include a more principled and comprehensive computational model of reasoning in both adults and children. The project should provide significant benefits by helping to resolve long-standing debates about how humans reason complex arguments relevant to everyday lives and guide development of more effective methods for teaching reasoning.Read moreRead less
ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for ....ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for and make better decisions for an ageing world, with consequent social and economic benefits for families and communities expected to flow to Australia, the Asian region and the world.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100702
Funder
Australian Research Council
Funding Amount
$859,472.00
Summary
Optimising sleep, alertness and safety in shift work industries. This project aims to address the impaired alertness, and high risk of workplace errors and accidents that are associated with sleep loss and circadian misalignment during shift work. The project will deliver an innovative industry-driven digital technology to provide automated, customised sleep management strategies to shift workers, and will develop a framework for effective wide-scale deployment of the technology within Australia ....Optimising sleep, alertness and safety in shift work industries. This project aims to address the impaired alertness, and high risk of workplace errors and accidents that are associated with sleep loss and circadian misalignment during shift work. The project will deliver an innovative industry-driven digital technology to provide automated, customised sleep management strategies to shift workers, and will develop a framework for effective wide-scale deployment of the technology within Australian shift working organisations. The project will close the gap in resources currently available to support sleep in shift workers and will reduce the significant burdens of shift work for alertness, productivity and safety.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100019
Funder
Australian Research Council
Funding Amount
$4,583,816.00
Summary
ARC Training Centre for Optimal Ageing. The ARC Training Centre for Optimal Ageing aims to address issues identified by older adults as essential for quality of life. With our industry partners, we aim to train the next generation of researchers to understand, detect and improve psychosocial factors that support mental activity, physical health and social connectedness, and embrace advances in artificial intelligence, digital-enriched environments and adaptive workplaces to deliver effective dig ....ARC Training Centre for Optimal Ageing. The ARC Training Centre for Optimal Ageing aims to address issues identified by older adults as essential for quality of life. With our industry partners, we aim to train the next generation of researchers to understand, detect and improve psychosocial factors that support mental activity, physical health and social connectedness, and embrace advances in artificial intelligence, digital-enriched environments and adaptive workplaces to deliver effective digital solutions. By developing new capacity and capability to drive the digital transformation of industries supporting our ageing population, our Centre seeks to deliver economic and social benefits that enable Australians to live enriched, healthy and independent lives as they age.Read moreRead less