Discovery Early Career Researcher Award - Grant ID: DE220100006
Funder
Australian Research Council
Funding Amount
$383,872.00
Summary
Determining the regulation of ovary development with single cell sequencing. This project will greatly advance our understanding of ovary development and mammalian reproduction. I will investigate the process of ovarian primordial follicle activation including its genetic regulation, the importance of supportive granulosa cells and the biological significance of regulatory factors. This will be achieved through the comprehensive investigation of a single cell transcriptomic dataset of ovarian de ....Determining the regulation of ovary development with single cell sequencing. This project will greatly advance our understanding of ovary development and mammalian reproduction. I will investigate the process of ovarian primordial follicle activation including its genetic regulation, the importance of supportive granulosa cells and the biological significance of regulatory factors. This will be achieved through the comprehensive investigation of a single cell transcriptomic dataset of ovarian development (Aim 1) in conjunction with functional studies (Aim 2). The outcomes of which will hold significant benefit to animal reproduction through new strategies to improve livestock productivity and control invasive pest species. These outcomes are of economic and environmental and benefit nationally.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100032
Funder
Australian Research Council
Funding Amount
$379,264.00
Summary
Banking on spermatogonial stem cells to safeguard Australian native fauna. Spermatogonial stem cells in the testis are an untapped resource for species conservation. This project aims to characterise metabolic pathways that control spermatogonial stem cell function, and define the conserved nature of these pathways between model species (mouse) and vulnerable Australian native fauna. Expected outcomes of this project include an enhanced capacity to culture koala spermatogonia in vitro, which wil ....Banking on spermatogonial stem cells to safeguard Australian native fauna. Spermatogonial stem cells in the testis are an untapped resource for species conservation. This project aims to characterise metabolic pathways that control spermatogonial stem cell function, and define the conserved nature of these pathways between model species (mouse) and vulnerable Australian native fauna. Expected outcomes of this project include an enhanced capacity to culture koala spermatogonia in vitro, which will be a first step towards using spermatogonial biobanking as a tool to maintain genetic diversity in this species. Outcomes from this study should provide significant benefits in safeguarding our unique Australian native species, which is of particular importance following the catastrophic 2019/20 bushfire season.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100103
Funder
Australian Research Council
Funding Amount
$459,674.00
Summary
Fortifying animal and plant germ cells against proteotoxic stress. Cellular stress is responsible for widespread inefficiencies in plant and animal reproduction. Using high resolution proteomics and cryo-electron microscopy, this project aims to investigate how plant and animal germ cells respond to environmental stresses that are known to disrupt fertility, and assess two novel strategies to decrease the sensitivity of cells to stress. This project is expected to generate new global knowledge i ....Fortifying animal and plant germ cells against proteotoxic stress. Cellular stress is responsible for widespread inefficiencies in plant and animal reproduction. Using high resolution proteomics and cryo-electron microscopy, this project aims to investigate how plant and animal germ cells respond to environmental stresses that are known to disrupt fertility, and assess two novel strategies to decrease the sensitivity of cells to stress. This project is expected to generate new global knowledge in the area of fertility regulation with the potential to improve the tolerance of crop species to heat stress, prevent economic losses and help to secure future food production. Further, this project has the intended benefit of improving the fertility of animal species that suffer from stress-induced infertility.
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