Mobile DNA activity in the mammalian primordial germline. Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge a ....Mobile DNA activity in the mammalian primordial germline. Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge about the origins of mammalian genetic diversity. Expected outcomes include enhanced national and international collaborations across disciplines and new experimental systems. The expected benefit is an enhanced understanding of the mutational processes underlying genetic diversity and disease in mammals.Read moreRead less
Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing th ....Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing the proficiency of investigations into matters that rely on detailed and accurate accounts of specific episodes. This includes workplace or traffic accident investigations, infectious disease contact tracing, as well as prosecution of repeated sexual offences.Read moreRead less
Foundations of a good egg: correctly transitioning from mitosis to meiosis. Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initia ....Foundations of a good egg: correctly transitioning from mitosis to meiosis. Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initiate meiotic division instead. It is important to understand all the fundamental processes that occur during normal germ cell development so that, in the future, we can use this knowledge to support agricultural advances, rescue endangered species and solve human problems such as infertility and genetic disease.Read moreRead less
Mechanisms that control the inheritance of mitochondrial DNA mutations. How do humans and other organisms prevent the accumulation of dangerous mitochondrial genome (mtDNA) mutations across generations? This Project aims to uncover the cellular and molecular pathways that help prevent the inheritance of mtDNA mutations to offspring by employing cutting-edge genetic technologies that the laboratory has recently developed in the germline of an animal model system. This Project will generate new kn ....Mechanisms that control the inheritance of mitochondrial DNA mutations. How do humans and other organisms prevent the accumulation of dangerous mitochondrial genome (mtDNA) mutations across generations? This Project aims to uncover the cellular and molecular pathways that help prevent the inheritance of mtDNA mutations to offspring by employing cutting-edge genetic technologies that the laboratory has recently developed in the germline of an animal model system. This Project will generate new knowledge in the area of mitochondrial genetics and evolution. Expected outcomes include the development of new theories for mtDNA inheritance, which should provide significant benefits for agricultural breeding programs and the interpretation of mtDNA inheritance patterns in the human population.Read moreRead less
Attentional mechanisms in the relationship between sleep disruption and academic outcomes in Australian school children. This project will assess the impact of sleep problems on attention and academic performance in primary school children. The project will investigate typically developing children and children with developmental disorders over 18 months. The research will advance knowledge of the interplay between sleep, attention and learning across development.
Morphological development of the kidney – a paradigm for organogenesis. This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore h ....Morphological development of the kidney – a paradigm for organogenesis. This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore how this pattern is established, how it dictates kidney development and whether it constitutes an ancient mechanism central to organ formation. Project outcomes may improve understanding of fundamental developmental processes and developmental disease and variation. Project findings may also be important for understanding the development of other organ systems.Read moreRead less
The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations ....The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations will predict the development of alcohol/tobacco use and misuse, after accounting for viable alternative explanations of the association. Understanding the role that memory associations have in the development of alcohol/tobacco use should inform prevention programs for at-risk adolescents.Read moreRead less
To imitate or innovate: A new look at children's social learning strategies. Children learn many important things by copying others. But how do we best facilitate this where it’s culturally appropriate or encourage innovation to support more general learning? This developmental psychology project aims to provide answers, using novel experiments and comparisons of different cultural groups to show how children acquire skills while becoming valued community members. Expected outcomes include the r ....To imitate or innovate: A new look at children's social learning strategies. Children learn many important things by copying others. But how do we best facilitate this where it’s culturally appropriate or encourage innovation to support more general learning? This developmental psychology project aims to provide answers, using novel experiments and comparisons of different cultural groups to show how children acquire skills while becoming valued community members. Expected outcomes include the refinement of core developmental psychology theory, introduction of new experimental techniques, and strengthening of international collaborations. This should provide significant benefits to educators, policy makers, parents and those invested in understanding and improving the inter-generational transmission of knowledge.Read moreRead less
Imitation learning in infancy. We copy others all the time, to learn new skills and to connect socially and emotionally with those around us. But where does this ability to imitate come from? This is a long-standing question in developmental psychology that the proposed project aims to answer. Using a unique combination of EMG and behavioural observations, this project will chart infants’ imitation skills from birth through the first year of life, and test whether infants learn to imitate from ....Imitation learning in infancy. We copy others all the time, to learn new skills and to connect socially and emotionally with those around us. But where does this ability to imitate come from? This is a long-standing question in developmental psychology that the proposed project aims to answer. Using a unique combination of EMG and behavioural observations, this project will chart infants’ imitation skills from birth through the first year of life, and test whether infants learn to imitate from watching themselves and being imitated by others. The new knowledge arising from this research will clarify the origins of our uniquely human sociality. The outcomes should also enable earlier identification of developmental problems and provide novel avenues for intervention.Read moreRead less
The developmental origins of tool innovation. Solving new problems by making new tools, or using old tools in new ways, is a hallmark of our species. Theoretical and experimental enquiry into children’s developing socio-cognitive abilities conflicts with recent research suggesting young children are poor tool innovators. This project will be the first to confidently disambiguate our knowledge about whether children are capable of tool innovation by systematically investigating their abilities us ....The developmental origins of tool innovation. Solving new problems by making new tools, or using old tools in new ways, is a hallmark of our species. Theoretical and experimental enquiry into children’s developing socio-cognitive abilities conflicts with recent research suggesting young children are poor tool innovators. This project will be the first to confidently disambiguate our knowledge about whether children are capable of tool innovation by systematically investigating their abilities using a new comprehensive battery of tasks, novel test conditions and the integration of data from industrialised and indigenous communities in Australia and Southern Africa. This research will provide the broadest insights yet into the development of a key feature of the human condition.Read moreRead less