The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Ascorbate and glutathione integrate the control of grapevine development. This project aims to make a step-change in understanding how the growth of woody perennial crops is regulated. The study of herbaceous annual plants has established that the antioxidants, ascorbate and glutathione, are important in regulating every step of plant development. However, this cannot readily translate to perennial life cycles. This project will develop novel genetic tools in grapevine that enable functional stu ....Ascorbate and glutathione integrate the control of grapevine development. This project aims to make a step-change in understanding how the growth of woody perennial crops is regulated. The study of herbaceous annual plants has established that the antioxidants, ascorbate and glutathione, are important in regulating every step of plant development. However, this cannot readily translate to perennial life cycles. This project will develop novel genetic tools in grapevine that enable functional studies of these antioxidants in a perennial plant for the first time. It will investigate how ascorbate and glutathione regulate the development of grapevine, and how these functions integrate with hormone and energy metabolism. The outcomes will advance our ability to manage perennial crops in current and future climates.Read moreRead less
Signalling pathways for sexual differentiation of apicomplexan parasites. This project aims to study the sexual development of apicomplexan parasites, which cause major diseases in humans, livestock and wildlife, including malaria. Only sexually differentiated cells can survive in the mosquito vector and hence this development is essential for the parasite's life-cycle. This project will employ a new approach that separates female from male parasites, thus enabling new information to be gleaned ....Signalling pathways for sexual differentiation of apicomplexan parasites. This project aims to study the sexual development of apicomplexan parasites, which cause major diseases in humans, livestock and wildlife, including malaria. Only sexually differentiated cells can survive in the mosquito vector and hence this development is essential for the parasite's life-cycle. This project will employ a new approach that separates female from male parasites, thus enabling new information to be gleaned about the development of these parasites. The expected outcomes are an understanding of the mechanisms of sexual differentiation and a functional characterisation of novel sex-specific molecules. This will provide significant benefits, such as pivotal prerequisites for new approaches to parasite intervention.Read moreRead less
Improving plant reproductive success under heat stress: A sweet approach. This project aims to determine how genetic manipulation of cell wall invertase (CWIN) activity could regulate pollen germination, elongation and fruit set under heat stress using tomato as a model. Plant reproductive processes are highly susceptible to heat stress, which often leads to pollination failure and fruit and seed abortion, hence irreversible yield loss. Research has established that CWIN-mediated sugar metabolis ....Improving plant reproductive success under heat stress: A sweet approach. This project aims to determine how genetic manipulation of cell wall invertase (CWIN) activity could regulate pollen germination, elongation and fruit set under heat stress using tomato as a model. Plant reproductive processes are highly susceptible to heat stress, which often leads to pollination failure and fruit and seed abortion, hence irreversible yield loss. Research has established that CWIN-mediated sugar metabolism and signaling may play crucial roles in pollen growth and fruit set under heat stress. The intended outcome is the generation of critical knowledge that will advance understanding on reproductive development under heat stress, thereby providing significant benefits, such as novel ideas and solutions for improving crop yield.Read moreRead less
Unlocking secrets of fertility restoration for hybrid breeding in crops. Hybrid varieties give higher and more stable yields than conventional lines, but a cost-effective system to make hybrid seed on a commercial scale is still missing for economically important crops like wheat or barley. By elucidating the mode of action of a new type of restorer gene plus exploiting ancient or exotic wheat and barley collections this project will reveal aspects of largely understudied mechanisms underlying f ....Unlocking secrets of fertility restoration for hybrid breeding in crops. Hybrid varieties give higher and more stable yields than conventional lines, but a cost-effective system to make hybrid seed on a commercial scale is still missing for economically important crops like wheat or barley. By elucidating the mode of action of a new type of restorer gene plus exploiting ancient or exotic wheat and barley collections this project will reveal aspects of largely understudied mechanisms underlying fertility restoration in wheat and barley. The expected outcomes of the proposed research have the potential to deliver new tools for hybrid seed production programs in wheat and barley. Higher and more stable yields from hybrids will ensure food security in the face of an uncertain climate and growing human population.Read moreRead less
Financial decision making in late adulthood. The project aims to examine links between cognitive changes and financial decision-making in late adulthood and also to assess the preparedness of the elderly to combat financial risks due to age-related cognitive decline. Further, it intends to examine how age, education, wealth, health, and other environmental factors influence transfer of financial decision-making responsibilities to spouses or others. It is expected that the research will provide ....Financial decision making in late adulthood. The project aims to examine links between cognitive changes and financial decision-making in late adulthood and also to assess the preparedness of the elderly to combat financial risks due to age-related cognitive decline. Further, it intends to examine how age, education, wealth, health, and other environmental factors influence transfer of financial decision-making responsibilities to spouses or others. It is expected that the research will provide a greater understanding of how cognitive functioning and other factors affect older adults’ financial capacity and willingness to delegate decision-making responsibilities. This understanding could be used to inform policy initiatives to protect elderly individuals and their family members from the risk of financial mismanagement.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100078
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Strengthening parent-child relationships to promote child adjustment. This project aims to provide new insight into how biological and foster parents can support their children during periods of heightened vulnerability when they transition to high school or a new foster care placement. It aims to address the shortage of relationally-focused prevention strategies tailored to both biological and foster parents’ needs and delivered at critical transitions in children’s lives. Outcomes are expected ....Strengthening parent-child relationships to promote child adjustment. This project aims to provide new insight into how biological and foster parents can support their children during periods of heightened vulnerability when they transition to high school or a new foster care placement. It aims to address the shortage of relationally-focused prevention strategies tailored to both biological and foster parents’ needs and delivered at critical transitions in children’s lives. Outcomes are expected to shed light on the effects of attachment quality and to advance evidence-based psychological practice in enhancing child adjustment.Read moreRead less
Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two k ....Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two known lizard species exhibiting both genetic and temperature control of sex. This knowledge will have important implications for species conservation, facilitating predictions of highly biased sex ratios under climate change, plus potential commercial applications for species where production of one sex is favoured.Read moreRead less
Upholding the right to cultural connection for children in care. A positive sense of cultural identity is critical to wellbeing, yet children in out-of-home care often lose their cultural identities and connections. There is little evidence to guide out-of-home care agencies to support a culturally meaningful foster care placement for non-Indigenous culturally and linguistically diverse children. This project tests promising practices identified by the partner organisations and research literatu ....Upholding the right to cultural connection for children in care. A positive sense of cultural identity is critical to wellbeing, yet children in out-of-home care often lose their cultural identities and connections. There is little evidence to guide out-of-home care agencies to support a culturally meaningful foster care placement for non-Indigenous culturally and linguistically diverse children. This project tests promising practices identified by the partner organisations and research literature to produce an exemplary model of cultural care, with input from children, carers and birth families. Trial implementation in the partner organisations will inform guidelines and recommendations so that the model can inform policy and practice in out-of-home care across Australia.
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Discovery Early Career Researcher Award - Grant ID: DE210101881
Funder
Australian Research Council
Funding Amount
$407,390.00
Summary
Building STEM capacity through literacy engagement in spatial reasoning. This project aims to improve boys and girls' spatial reasoning in preschool (when gender differences emerge) by utilizing an activity that both genders equally access: book reading. Spatial reasoning is critical to achievement in science, technology, engineering and mathematics (STEM). This project will address disproportionate outcomes in spatial reasoning and STEM achievement, particularly among females, by identifying ef ....Building STEM capacity through literacy engagement in spatial reasoning. This project aims to improve boys and girls' spatial reasoning in preschool (when gender differences emerge) by utilizing an activity that both genders equally access: book reading. Spatial reasoning is critical to achievement in science, technology, engineering and mathematics (STEM). This project will address disproportionate outcomes in spatial reasoning and STEM achievement, particularly among females, by identifying effective kinds of spatial learning opportunities for the preschool context. Expected outcomes include an innovative approach to improving spatial reasoning through literacy engagement. This provides significant benefits by creating pathways into STEM and informing targeted interventions.Read moreRead less