Evolution of the dermomyotome in vertebrates. The project seeks to understand how different muscle populations within the embryo form and have evolved within the vertebrate phylogeny. All amniote muscles, except that of the head, derive from a transient embryonic structure termed the dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved mechanism that is distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to generate th ....Evolution of the dermomyotome in vertebrates. The project seeks to understand how different muscle populations within the embryo form and have evolved within the vertebrate phylogeny. All amniote muscles, except that of the head, derive from a transient embryonic structure termed the dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved mechanism that is distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to generate the distinct types of locomotor systems we see deployed throughout the vertebrate phylogeny remains unresolved. This project aims to contribute to an understanding of how different locomotor strategies deployed at important evolutionary transitions were generated.Read moreRead less
Fins to Limbs: Investigating the Evolution of complex Limb Musculature. This application aims to investigates the basis of the fin-to-limb transition, an event that set the stage for the entire tetrapod radiation. This project expects to generate new knowledge concerning the natural history of vertebrates using a multidisciplinary approach that combines paleontology and embryology of unique Australian fauna. While the skeletal changes associated with the move from water to land have been investi ....Fins to Limbs: Investigating the Evolution of complex Limb Musculature. This application aims to investigates the basis of the fin-to-limb transition, an event that set the stage for the entire tetrapod radiation. This project expects to generate new knowledge concerning the natural history of vertebrates using a multidisciplinary approach that combines paleontology and embryology of unique Australian fauna. While the skeletal changes associated with the move from water to land have been investigated, little is known about the origin of tetrapod limb muscles. This proposal has as an expected outcome, a determination of how limb muscles arose during evolution. This knowledge should provide significant benefits by transforming our understanding of the origins of the tetrapod body plan and our own natural history.Read moreRead less
Motor coordination in infancy and its relationship to motor and psychosocial development in childhood. Few studies have examined the impact of early motor development on later development, even though there is evidence to show that these early movements influence later motor ability. Motor development can also impact on cognitive, emotional and social development. The current study has data on early motor ability in over 90 infants which includes children at risk of developmental disorders. We ....Motor coordination in infancy and its relationship to motor and psychosocial development in childhood. Few studies have examined the impact of early motor development on later development, even though there is evidence to show that these early movements influence later motor ability. Motor development can also impact on cognitive, emotional and social development. The current study has data on early motor ability in over 90 infants which includes children at risk of developmental disorders. We will carry out a longitudinal investigation of the relationship between early motor development in infancy on motor and psychosocial development in childhood. The results will provide information on early markers for developmental disorders and appropriate intervention techniques than can be initiated in infancy. Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Protect, prepare and engage: Does extracurricular activity participation offer sustained benefits for youth? Organized extracurricular activities such as sport and music have the potential to promote healthy development and to reduce the levels of risk behaviours in teenagers. However, current research evidence, often based on middle-class youth in the US, is inadequate for making policy recommendations for improvement to the after-school lives of Australian youth. This study will offer insight ....Protect, prepare and engage: Does extracurricular activity participation offer sustained benefits for youth? Organized extracurricular activities such as sport and music have the potential to promote healthy development and to reduce the levels of risk behaviours in teenagers. However, current research evidence, often based on middle-class youth in the US, is inadequate for making policy recommendations for improvement to the after-school lives of Australian youth. This study will offer insight into the long-term benefits of making a diverse selection of organised activities available to Australian teenagers, and will improve our understanding of which aspects of participation are most likely to enhance their social and educational opportunities.Read moreRead less
The Role of Adaptive Coding Mechanisms in the Development of Face Perception. Faces are immensely rich in social information, and early difficulties in extracting such information can have profound consequences for later social functioning. This project will provide insights into the ways in which our face-reading abilities develop throughout childhood. In addition to helping us better understand normal social development, this research will provide a foundation for understanding how face-readi ....The Role of Adaptive Coding Mechanisms in the Development of Face Perception. Faces are immensely rich in social information, and early difficulties in extracting such information can have profound consequences for later social functioning. This project will provide insights into the ways in which our face-reading abilities develop throughout childhood. In addition to helping us better understand normal social development, this research will provide a foundation for understanding how face-reading difficulties can affect people with developmental disorders (such as autism), how face-reading can be disrupted in individuals whose early visual experience is affected by cataracts at birth, and how such difficulties might be alleviated through clinical intervention.Read moreRead less
The role of extracurricular activity participation in promoting healthy development of Australian youth. Organized extracurricular activities such as sport and art have the potential for promoting healthy development and reducing the risks faced by teenagers. However, current research evidence, often based on middle-class youth in the US, is inadequate for making policy recommendations for improvement to the after-school lives of Australian youth. This study will offer insight into the importanc ....The role of extracurricular activity participation in promoting healthy development of Australian youth. Organized extracurricular activities such as sport and art have the potential for promoting healthy development and reducing the risks faced by teenagers. However, current research evidence, often based on middle-class youth in the US, is inadequate for making policy recommendations for improvement to the after-school lives of Australian youth. This study will offer insight into the importance of making a diverse selection of organized activities available to Australian teenagers, and will improve our understanding of which aspects of participation are most likely to enhance their social and educational opportunities.Read moreRead less
Oxygen Signalling in Grapevine Bud Dormancy. Dormancy is an important economic and ecological trait of many trees and crop plants, including most commercially valuable fruit species. This project aims to: define oxygen and radicals of oxygen as central cues of grapevine bud development and dormancy; identify and model the developmental processes that occur during dormancy onset, maintenance and release (bud burst); as well as to identify the molecular and biochemical regulators of oxygen signals ....Oxygen Signalling in Grapevine Bud Dormancy. Dormancy is an important economic and ecological trait of many trees and crop plants, including most commercially valuable fruit species. This project aims to: define oxygen and radicals of oxygen as central cues of grapevine bud development and dormancy; identify and model the developmental processes that occur during dormancy onset, maintenance and release (bud burst); as well as to identify the molecular and biochemical regulators of oxygen signals in bud dormancy. The knowledge generated could provide a platform to test impacts of climate change on fruit and tree species, and lead to better management of fruit and tree species in agricultural and ecological systems.Read moreRead less
Memory Consolidation and Educational Achievement in Children. The National Report on Schooling in Australia 2006 reports that between 7-12% of children in Years 3 and 5 failed to meet literacy and numeracy benchmarks. Evidence suggests that poor working memory skills may be a key feature in children's failure to achieve in school. By investigating the cognitive factors that underlie variation in working memory ability, the proposed research has the potential to improve educational outcomes in Au ....Memory Consolidation and Educational Achievement in Children. The National Report on Schooling in Australia 2006 reports that between 7-12% of children in Years 3 and 5 failed to meet literacy and numeracy benchmarks. Evidence suggests that poor working memory skills may be a key feature in children's failure to achieve in school. By investigating the cognitive factors that underlie variation in working memory ability, the proposed research has the potential to improve educational outcomes in Australian children. If memory consolidation is found to be important, this would guide the development of effective teaching strategies and early intervention programs for 'at-risk' children in line with the National Literacy and Numeracy Plan.Read moreRead less
Understanding the link between reading impairments and emotional problems. This Project aims to understand why children with reading impairments are at increased risk for emotional problems. By integrating the statistical power of large-scale longitudinal studies with the causal testing power of intervention case studies, it seeks to fast-track the development of a comprehensive evidence-based theory of the mechanisms linking reading impairments and emotional problems. The outcomes will pave the ....Understanding the link between reading impairments and emotional problems. This Project aims to understand why children with reading impairments are at increased risk for emotional problems. By integrating the statistical power of large-scale longitudinal studies with the causal testing power of intervention case studies, it seeks to fast-track the development of a comprehensive evidence-based theory of the mechanisms linking reading impairments and emotional problems. The outcomes will pave the way for future diagnosis and treatment of concomitant reading and emotional difficulties in children. These outcomes improve our capacity to reduce the incidence of two common problems that limit the life success of Australian children - poor literacy and poor emotional health.Read moreRead less