Understanding the evolution of the alternation of generations in the land plant life cycle. This project will investigate the genetic basis and evolution of the land plant life cycle, in which both haploid and diploid phases consist of complex multicellular bodies. The project's findings, which will be made using two model laboratory plants, will be applicable to all plants and will help understand important processes such as pollen and seed production.
Using genetics to recover Australia's lost history. This project aims to use historic hair samples collected by anthropological expeditions in the early 20th Century to generate the first genetic map of Aboriginal Australia – in order to reconstruct Australia’s pre-European genetic and cultural past. The map and the detailed contextual and genealogical information from museum archives will assist Aboriginal communities and individuals to reconstruct their personal and family history and trace an ....Using genetics to recover Australia's lost history. This project aims to use historic hair samples collected by anthropological expeditions in the early 20th Century to generate the first genetic map of Aboriginal Australia – in order to reconstruct Australia’s pre-European genetic and cultural past. The map and the detailed contextual and genealogical information from museum archives will assist Aboriginal communities and individuals to reconstruct their personal and family history and trace ancestry and augment oral or written records. The combination of cutting-edge science, detailed archival research, and a comprehensive family outreach and reporting program will be a step change in assisting Australia’s reconciliation process, the Stolen Generation, and repatriation of Indigenous remains.Read moreRead less
Developing new methods to retrieve and analyse preserved genetic information. This project will position Australia at the leading edge of research into preserved DNA, and will use innovative molecular biology approaches to develop a range of new forensic, archaeological and medical applications. It will build Australian knowledge and scientific capacity by developing core expertise and training personnel in areas important for biosecurity, customs and quarantine, forensics/counter-terrorism, and ....Developing new methods to retrieve and analyse preserved genetic information. This project will position Australia at the leading edge of research into preserved DNA, and will use innovative molecular biology approaches to develop a range of new forensic, archaeological and medical applications. It will build Australian knowledge and scientific capacity by developing core expertise and training personnel in areas important for biosecurity, customs and quarantine, forensics/counter-terrorism, and studies of climate change. It will also create and foster research innovation in molecular biology with spin-offs for evolution, archaeology, medical and conservation biology research, and will also encourage involvement with the rapidly expanding field of genomics and bioinformatics.Read moreRead less
The role of online social networks in successful ageing: benefitting from 'who you know' at older ages. The project will increase understanding of how online social networking contributes to successful ageing through partnering, economic and voluntary activity, family and social connectedness. The findings will inform policy recommendations, social interventions and education programs designed to enhance 'ageing well, ageing productively'. These are expected to benefit the health and well-being ....The role of online social networks in successful ageing: benefitting from 'who you know' at older ages. The project will increase understanding of how online social networking contributes to successful ageing through partnering, economic and voluntary activity, family and social connectedness. The findings will inform policy recommendations, social interventions and education programs designed to enhance 'ageing well, ageing productively'. These are expected to benefit the health and well-being of older Australians, with economic benefits of increased contributions to society and fewer demands on services. Social and economic benefits are also expected from insights into reducing the technological and psychological barriers that prevent older people from benefiting from the Internet and online social networking.Read moreRead less
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Normative study of a checklist of emotional and behavioural disturbance in adults with intellectual disability. People with intellectual disability (ID) are three times more likely to suffer mental illness than the general community, making this a bigger problem than schizophrenia. They are a great burden to their carers and cost to the community but their mental health problems remain largely untreated. This study aims to conduct the largest and most comprehensive survey of the mental health ....Normative study of a checklist of emotional and behavioural disturbance in adults with intellectual disability. People with intellectual disability (ID) are three times more likely to suffer mental illness than the general community, making this a bigger problem than schizophrenia. They are a great burden to their carers and cost to the community but their mental health problems remain largely untreated. This study aims to conduct the largest and most comprehensive survey of the mental health of adults with ID that has been undertaken internationally to date. The population will cover the age span of late adolescence (16 years) through the transition to adult life then through to the elderly. The research will establish the prevalence and nature of mental illness and potential risk factors in a large representative population of adults with ID.Read moreRead less
Genomics for persistence of Australian freshwater fish. Biodiversity faces an unpredictable cocktail of impacts and global environmental change, against which the best insurance is genetic diversity. We will develop genomic measures of ecological-genetic functions and evolutionary potential for managing Australian freshwater fish.
Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing seque ....Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing sequences and genes in microchromosomes of birds, reptiles and monotremes. This will clarify the origin and evolution of the ?microgenome?, establish its suitability as a model for vertebrate genome organisation, and demonstrate whether microchromosomes are the ancestors of the gene-rich regions of mammalian chromosomes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101069
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Adaptation and diversification of the first peoples of Sahul. This project aims to further advance work on the genetic history of Indigenous Australians and Papuans that has revealed that Aboriginal Australians have inhabited a variety of diverse and challenging environments for approximately 50,000 years. Using novel techniques for extraction of human DNA from soil and the use of cutting-edge graph-based methods, hundreds of Indigenous Australian and Papuan genomes will be analysed. This projec ....Adaptation and diversification of the first peoples of Sahul. This project aims to further advance work on the genetic history of Indigenous Australians and Papuans that has revealed that Aboriginal Australians have inhabited a variety of diverse and challenging environments for approximately 50,000 years. Using novel techniques for extraction of human DNA from soil and the use of cutting-edge graph-based methods, hundreds of Indigenous Australian and Papuan genomes will be analysed. This project expects to generate new knowledge by filling in the gaps in the Australian genetic record via ancient human DNA from sediments. Expected outcomes from this project are producing a detailed picture of genomic adaptation in Indigenous Australians and Papuans and creating a comprehensive genetic history of the First Peoples of Sahul.Read moreRead less