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The transcriptional control of lymphatic vessel development. Lymphatic vessels are a vital, but often overlooked, component of the cardiovascular system. These specialised vessels return tissue fluid to the bloodstream, absorb dietary lipids and transport cells of the immune system throughout the body. Defects in the growth and development of lymphatic vessels result in disorders including lymphedema, obesity, inflammatory diseases and cancer. This project aims to define how transcription factor ....The transcriptional control of lymphatic vessel development. Lymphatic vessels are a vital, but often overlooked, component of the cardiovascular system. These specialised vessels return tissue fluid to the bloodstream, absorb dietary lipids and transport cells of the immune system throughout the body. Defects in the growth and development of lymphatic vessels result in disorders including lymphedema, obesity, inflammatory diseases and cancer. This project aims to define how transcription factors program lymphatic vessel identity and control the development of lymphatic vessel valves. This knowledge will provide new insight into the fundamental mechanisms by which the lymphatic vasculature is constructed during development.Read moreRead less
Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, ....Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.Read moreRead less
The birth and death of mammalian sex chromosomes. This project aims to unravel the molecular mechanisms that underlie the transition from autosome to sex chromosome and progressive sex chromosome differentiation in mammals. Monotremes are the only mammalian species with a sex chromosome system that consists of ten sex chromosomes in platypus and nine in echidna. This project will analyse the genetic and epigenetic composition and organisation of the monotreme autosomes that evolved into sex chro ....The birth and death of mammalian sex chromosomes. This project aims to unravel the molecular mechanisms that underlie the transition from autosome to sex chromosome and progressive sex chromosome differentiation in mammals. Monotremes are the only mammalian species with a sex chromosome system that consists of ten sex chromosomes in platypus and nine in echidna. This project will analyse the genetic and epigenetic composition and organisation of the monotreme autosomes that evolved into sex chromosomes in other mammals and compare individual platypus and echidna sex chromosomes to discover how sex chromosomes come to be, differentiate and ultimately are replaced by new sex chromosomes.Read moreRead less
Normal heart development before birth. This project aims to understand how the fetal heart can develop normally with much less oxygen than an adult heart uses. Regulation of fetal heart proliferation is not well understood but changes in oxygen levels and non-coding RNAs are implicated. Using advanced imaging techniques to measure blood flow in blood vessels to the fetal heart and molecular probes to assess cell function and microarrays to measure non-coding RNA, the project expects to generate ....Normal heart development before birth. This project aims to understand how the fetal heart can develop normally with much less oxygen than an adult heart uses. Regulation of fetal heart proliferation is not well understood but changes in oxygen levels and non-coding RNAs are implicated. Using advanced imaging techniques to measure blood flow in blood vessels to the fetal heart and molecular probes to assess cell function and microarrays to measure non-coding RNA, the project expects to generate new knowledge about mechanisms of fetal heart cell proliferation. Ultimately, this new knowledge could lead to non-invasive approaches to detect and treat abnormal fetal heart growth in animals and humans.Read moreRead less
Targeting root architecture to improve plant production in sub-optimal soil. This project aims to identify important missing links in the signalling pathways that connect major plant hormones in their control of root architecture, with a focus on the signalling system that helps plants cope with sub-optimal growing conditions. New discoveries in plant hormones will be applied to crops to provide a deeper understanding of root growth responses under sub-optimal conditions, and to maximise plant e ....Targeting root architecture to improve plant production in sub-optimal soil. This project aims to identify important missing links in the signalling pathways that connect major plant hormones in their control of root architecture, with a focus on the signalling system that helps plants cope with sub-optimal growing conditions. New discoveries in plant hormones will be applied to crops to provide a deeper understanding of root growth responses under sub-optimal conditions, and to maximise plant efficiency. Expected outcomes include a better understanding of signal pathways in roots, improved knowledge about how crops respond to adverse conditions, new knowledge and potential genetic resources for plant industry, and novel ideas about how to improve crop productivity.Read moreRead less
Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen recepto ....Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen receptor (AR)-targeting therapies in human prostate tumours. The identification and functional assessment of these biomarkers will identify those that can be used as surrogate endpoints in clinical trials, facilitate earlier approval of investigational agents and lead to improved options for therapeutic management of prostate cancer.Read moreRead less
Defining pathways that establish and maintain reproductive cell identity in plant ovules and seeds. Unlike animals, individual somatic cells in plants have the remarkable ability to regenerate into new plants, depending on the signals they perceive. This developmental plasticity is particularly important during normal plant growth, when mature cells adopt new identities within multicellular environments. Tissue complexity is critical for the utilisation of plants in society as food, fuel and fib ....Defining pathways that establish and maintain reproductive cell identity in plant ovules and seeds. Unlike animals, individual somatic cells in plants have the remarkable ability to regenerate into new plants, depending on the signals they perceive. This developmental plasticity is particularly important during normal plant growth, when mature cells adopt new identities within multicellular environments. Tissue complexity is critical for the utilisation of plants in society as food, fuel and fibre, but how and why plant cells adopt or change identity has been difficult to determine. This project aims to employ next-generation molecular methods to identify pathways driving differentiation of specific ovule and seed cell-types, which directly impact crop quality, yield and end-use.Read moreRead less
Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease. Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases th ....Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease. Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases that threaten vision. This project will investigate molecular activities of retinal endothelial cells that are relevant to retinal disease processes and explore future biological therapies directed against the human retinal endothelial cell that address efficacy and safety deficiencies of current treatments.Read moreRead less
Social relations and social engagement in older adulthood: implications for health, well being and cognition. This project will examine the nature of changes in peoples social networks that occur with age and the effects of these changes on health and well being in later life. The project will use information collected as part of several ongoing Australian studies of ageing and will have implications for social policy.
Regulation of tissue morphogenesis in reproductive function and metastatic cancer. Infertility, endocrine and metabolic disorders and reproductive cancers are all increasing medical problems and principal contributors to morbidity and mortality in the Australian community. This research takes the novel approach of investigating the mechanisms of dynamic remodeling in reproductive organs. Novel hormonally controlled mechanisms of tissue remodeling unique to reproductive organs and cancers in ad ....Regulation of tissue morphogenesis in reproductive function and metastatic cancer. Infertility, endocrine and metabolic disorders and reproductive cancers are all increasing medical problems and principal contributors to morbidity and mortality in the Australian community. This research takes the novel approach of investigating the mechanisms of dynamic remodeling in reproductive organs. Novel hormonally controlled mechanisms of tissue remodeling unique to reproductive organs and cancers in adults have been discovered. The results are being applied to new medical alternatives for infertile patients and new diagnostics and therapeutics for patients with metastatic cancers. The information is also being applied to improve reproductive efficiency in animal production industries.Read moreRead less