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Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
Growing up with Cancer: A mixed method examination of how cancer influences the transition from adolescence to adulthood. In the last decade, over 10,000 of Australia's adolescents and young adults were diagnosed with cancer. Over the last 30 years, improvements in survival for 15 - 30 year olds have been the lowest of all age groups.Despite this, few health care facilities have the specialised infrastructure needed for dedicated psychosocial support of adolescents.
In finding out from adolescen ....Growing up with Cancer: A mixed method examination of how cancer influences the transition from adolescence to adulthood. In the last decade, over 10,000 of Australia's adolescents and young adults were diagnosed with cancer. Over the last 30 years, improvements in survival for 15 - 30 year olds have been the lowest of all age groups.Despite this, few health care facilities have the specialised infrastructure needed for dedicated psychosocial support of adolescents.
In finding out from adolescents with cancer what is most important in their care, we aim to identify and develop a range of services dedicated not only to addressing some of their needs, but also to building upon aspects of the cancer experience thought by adolescents as having a positive impact on their lives.Read moreRead less
SPECTRAL TILT: DO INFANTS KNOW WHAT'S GOOD FOR THEM? This project falls within the National Research Priorities, giving children 'a healthy start to life'. The research is important economically because it will lay the groundwork for the informed design of hearing aid frequency responses based on empirical research, and give infants the opportunity to be fitted with hearing aids amplified for infants, not adults as is the current unsatisfactory practice. Moreover, the cross fertilisation of meth ....SPECTRAL TILT: DO INFANTS KNOW WHAT'S GOOD FOR THEM? This project falls within the National Research Priorities, giving children 'a healthy start to life'. The research is important economically because it will lay the groundwork for the informed design of hearing aid frequency responses based on empirical research, and give infants the opportunity to be fitted with hearing aids amplified for infants, not adults as is the current unsatisfactory practice. Moreover, the cross fertilisation of methods and knowledge that the collaborators bring to this grant should provide outcomes that will help maintain attention on Australia as a site of cutting edge research into hearing impairment, hearing aid development and use.Read moreRead less
Speech production in the developing brain. This project aims to study how children acquire language. Speech is arguably the most complicated action that humans can perform, yet is acquired with apparent ease in the pre-school years. The brain mechanisms of speech production have rarely been studied in children due to methodological and technical challenges. This project will address this gap using an articulographic setup for measuring speech movements concurrently with scanning of brain activit ....Speech production in the developing brain. This project aims to study how children acquire language. Speech is arguably the most complicated action that humans can perform, yet is acquired with apparent ease in the pre-school years. The brain mechanisms of speech production have rarely been studied in children due to methodological and technical challenges. This project will address this gap using an articulographic setup for measuring speech movements concurrently with scanning of brain activity in a customised paediatric brain imaging system. The results are expected to help explain why most children acquire speech easily and smoothly and why this process can be more difficult for others.Read moreRead less
The role of preferred brain states in perceptual and cognitive processing: New insights into brain dynamics. New insights into brain dynamics will improve our understanding of both normal and atypical functioning. Extending previous work on normals will confirm how innovative Australian approaches can lead the research agenda in basic neuroscience, at the psychology-physiology interface. Testing in AD/HD and elderly populations will clarify dysfunctional brain mechanisms underlying AD/HD, and th ....The role of preferred brain states in perceptual and cognitive processing: New insights into brain dynamics. New insights into brain dynamics will improve our understanding of both normal and atypical functioning. Extending previous work on normals will confirm how innovative Australian approaches can lead the research agenda in basic neuroscience, at the psychology-physiology interface. Testing in AD/HD and elderly populations will clarify dysfunctional brain mechanisms underlying AD/HD, and the cognitive losses in elderly populations (exacerbated by dementia). These results may lead to better diagnosis, treatment, and community understanding of these groups. Also, publications on these target groups will demonstrate internationally the widespread utility of this approach, encouraging further novel applications of basic neuroscience in health.Read moreRead less
A novel DNA damage repair protein as a regulator of DNA double strand break repair and genome integrity. This project aims to define the function of a novel DNA damage repair protein. These data will provide a better understanding of DNA repair biology and may reveal novel diagnostic and treatment options for many diseases associated with DNA repair defects, including cancer.
Discovery Early Career Researcher Award - Grant ID: DE220100323
Funder
Australian Research Council
Funding Amount
$417,505.00
Summary
I can't find the word! Reading to maintain communication skills in ageing. This project aims to investigate why, as we age, we have trouble retrieving words when we speak but not when we read aloud. It takes the novel approach of systematically testing both reading and speaking in the same older adults. Through its innovative use of both behavioural research and computational modelling, it will generate new knowledge in spoken word production and reading, areas in which the project team have ack ....I can't find the word! Reading to maintain communication skills in ageing. This project aims to investigate why, as we age, we have trouble retrieving words when we speak but not when we read aloud. It takes the novel approach of systematically testing both reading and speaking in the same older adults. Through its innovative use of both behavioural research and computational modelling, it will generate new knowledge in spoken word production and reading, areas in which the project team have acknowledged expertise. This project will advance theories, achieving understanding of how ageing affects the cognitive systems involved in saying words and reading them aloud. By also investigating whether reading aloud can support word retrieval, it has potential future benefit for improved communication in older adults.Read moreRead less
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100306
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Does spurious maternal-fetal signalling support the evolution of a placenta. This project aims to test a model that explains how the placenta has evolved as a new organ more than 100 times in fishes, reptiles, and mammals including our own ancestors. The project will assess whether regulatory components of the placenta evolve as a result of spurious maternal-fetal signalling following egg retention and eggshell loss in viviparous reptiles. Expected outcomes of this project include a new understa ....Does spurious maternal-fetal signalling support the evolution of a placenta. This project aims to test a model that explains how the placenta has evolved as a new organ more than 100 times in fishes, reptiles, and mammals including our own ancestors. The project will assess whether regulatory components of the placenta evolve as a result of spurious maternal-fetal signalling following egg retention and eggshell loss in viviparous reptiles. Expected outcomes of this project include a new understanding of how complex organs originate and evolve in animals. This will benefit society through a broader depth of understanding of our own evolutionary history and provides a framework for future studies to investigate the origin and evolution of organs more broadly in animals.Read moreRead less
Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new ....Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new knowledge about the unique biology of Australia's marsupial fauna.This project will provide significant benefits, including enhanced capacity for reproduction research in Australia, new international collaborations between Melbourne and Yale, and a new explanation for the puzzling role of inflammation in pregnancy.Read moreRead less