Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new ....Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new knowledge about the unique biology of Australia's marsupial fauna.This project will provide significant benefits, including enhanced capacity for reproduction research in Australia, new international collaborations between Melbourne and Yale, and a new explanation for the puzzling role of inflammation in pregnancy.Read moreRead less
Old genes learning new tricks: characterising regulatory changes driving increased heart complexity during vertebrate evolution. The heart has dramatically increased in morphological complexity during vertebrate evolution but the molecular basis driving these major changes remains unknown. Using comparative genomics approaches, this project will explore changes in the regulation of genes involved in heart formation that lead to changes in cardiac structure. It will elucidate for the first time t ....Old genes learning new tricks: characterising regulatory changes driving increased heart complexity during vertebrate evolution. The heart has dramatically increased in morphological complexity during vertebrate evolution but the molecular basis driving these major changes remains unknown. Using comparative genomics approaches, this project will explore changes in the regulation of genes involved in heart formation that lead to changes in cardiac structure. It will elucidate for the first time the cardiac regulatory repertoire in zebrafish and will compare it with that of fly and mouse using cutting-edge bioinformatics pipelines. This work will unravel cardiac-specific regulatory modifications that give rise to evolutionary changes. On a broader scale, it will shed new light on the role of regulatory innovations over gene innovations in the emergence of new traits.Read moreRead less
Social outcomes, behaviour and emotional well-being of adults with autism. It is recognised that autism results in substantial life-long disability. Severe emotional and behavioural problems are likely to be a key factor in precluding adults with autism from work, independent living, social contact, and undermine their quality of life, thus increasing support needs. This project aims to address a major gap in our current knowledge - the association between severe emotional and behavioural proble ....Social outcomes, behaviour and emotional well-being of adults with autism. It is recognised that autism results in substantial life-long disability. Severe emotional and behavioural problems are likely to be a key factor in precluding adults with autism from work, independent living, social contact, and undermine their quality of life, thus increasing support needs. This project aims to address a major gap in our current knowledge - the association between severe emotional and behavioural problems in adults with autism and social outcomes. Identification of markers of adult outcomes aims to lead to an improved understanding of the pathways to better social outcomes, facilitating the development of specific interventions to provide much needed improvements in outcomes for adults with autism.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Linking arterial, brain and cognitive integrity in healthy older adults. This project aims to demonstrate that engaging the brain’s prefrontal cortex, an area that is highly sensitive to ageing, can improve the function of arteries that supply blood to this brain region. Using an innovative optical imaging methodology that maps the brain’s regional arterial health, it aims to generate new knowledge about the link between this arterial system and the progressive decline in cognitive control abili ....Linking arterial, brain and cognitive integrity in healthy older adults. This project aims to demonstrate that engaging the brain’s prefrontal cortex, an area that is highly sensitive to ageing, can improve the function of arteries that supply blood to this brain region. Using an innovative optical imaging methodology that maps the brain’s regional arterial health, it aims to generate new knowledge about the link between this arterial system and the progressive decline in cognitive control ability and in prefrontal cortex structure and function in healthy older adults. This interdisciplinary, international collaboration aims to put Australia at the forefront of brain optical imaging methods that may have significant benefits by informing approaches to promote and maintain healthy brain and cognition in old age.Read moreRead less
Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professiona ....Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professionals to identify early those youth at risk of having poor psychological, health, and employment prospects post-school. The project will inform the development of intervention programs for young people and maximise their overall adjustment and well-being several years later.Read moreRead less
Modelling trajectories of cognitive control in adolescents and young adults. This project aims to develop an innovative framework that models behaviour, brain function and brain structure to characterise developmental trajectories of cognitive control in typically-developing young people, and to test the model’s ability to predict psychosocial outcomes. Cognitive control processes are supported by complex frontal brain networks that develop well into adulthood. Poor cognitive control is linked t ....Modelling trajectories of cognitive control in adolescents and young adults. This project aims to develop an innovative framework that models behaviour, brain function and brain structure to characterise developmental trajectories of cognitive control in typically-developing young people, and to test the model’s ability to predict psychosocial outcomes. Cognitive control processes are supported by complex frontal brain networks that develop well into adulthood. Poor cognitive control is linked to negative psychosocial outcomes (e.g. substance use, high-risk behaviours). This work is expected to inform evidence-based programmes that identify young people at risk and develop targeted training strategies to improve psychosocial outcomes.Read moreRead less
Assessment of circadian and light interactions in adolescent sleepiness. This project aims to examine the relative contributions of multiple biological clock and sleep factors that may be linked to cognitive function and sleepiness in adolescents. Over 70 per cent of adolescents in Australia experience insufficient sleep. Cross-sectional studies have shown that insufficient sleep and mistimed sleep lead to reduced cognitive function. The project intends to identify specific sleep and circadian m ....Assessment of circadian and light interactions in adolescent sleepiness. This project aims to examine the relative contributions of multiple biological clock and sleep factors that may be linked to cognitive function and sleepiness in adolescents. Over 70 per cent of adolescents in Australia experience insufficient sleep. Cross-sectional studies have shown that insufficient sleep and mistimed sleep lead to reduced cognitive function. The project intends to identify specific sleep and circadian markers that are linked to academic performance, and generate innovative algorithms that predict these associations. The project will provide new knowledge to drive prevention and early intervention programs that use sleep-wake and light exposure information to improve sleep quality.Read moreRead less
Intergenerational Prediction of Social and Early Emotional Development. This project aims to investigate multi-generational influences on child psychosocial development. It plans to take advantage of a not-to-be-repeated opportunity to follow offspring born to one of Australia’s oldest longitudinal studies of social and emotional development. The Australian Temperament Project has followed around 2000 parents and offspring across 30 years from birth in 1983. Third-generation babies have been fol ....Intergenerational Prediction of Social and Early Emotional Development. This project aims to investigate multi-generational influences on child psychosocial development. It plans to take advantage of a not-to-be-repeated opportunity to follow offspring born to one of Australia’s oldest longitudinal studies of social and emotional development. The Australian Temperament Project has followed around 2000 parents and offspring across 30 years from birth in 1983. Third-generation babies have been followed across the peak period of first births to females. This project plans to continue recruitment across the peak period of first births for males in 2016–18. This would create one of the most extensive and well-powered three-generation resources worldwide, yielding unique data on intergenerational pathways through mother and father lines. It expects to inform targeting of interventions and psychosocial resources to promote wellbeing within and across generations.Read moreRead less
Preconception predictors of early childhood social and emotional development: a 30-year longitudinal study of grandparents, parents and children. There is increasing recognition of the importance of preconception pathways in shaping the family environments that parents provide for their children. This project will advance understandings of preconception pathways to healthy early child development, by recruiting offspring born to a 30-year longitudinal study: The Australian Temperament Study.