Mobile DNA activity in the mammalian primordial germline. Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge a ....Mobile DNA activity in the mammalian primordial germline. Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge about the origins of mammalian genetic diversity. Expected outcomes include enhanced national and international collaborations across disciplines and new experimental systems. The expected benefit is an enhanced understanding of the mutational processes underlying genetic diversity and disease in mammals.Read moreRead less
Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing th ....Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing the proficiency of investigations into matters that rely on detailed and accurate accounts of specific episodes. This includes workplace or traffic accident investigations, infectious disease contact tracing, as well as prosecution of repeated sexual offences.Read moreRead less
Foundations of a good egg: correctly transitioning from mitosis to meiosis. Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initia ....Foundations of a good egg: correctly transitioning from mitosis to meiosis. Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initiate meiotic division instead. It is important to understand all the fundamental processes that occur during normal germ cell development so that, in the future, we can use this knowledge to support agricultural advances, rescue endangered species and solve human problems such as infertility and genetic disease.Read moreRead less
Mechanisms that control the inheritance of mitochondrial DNA mutations. How do humans and other organisms prevent the accumulation of dangerous mitochondrial genome (mtDNA) mutations across generations? This Project aims to uncover the cellular and molecular pathways that help prevent the inheritance of mtDNA mutations to offspring by employing cutting-edge genetic technologies that the laboratory has recently developed in the germline of an animal model system. This Project will generate new kn ....Mechanisms that control the inheritance of mitochondrial DNA mutations. How do humans and other organisms prevent the accumulation of dangerous mitochondrial genome (mtDNA) mutations across generations? This Project aims to uncover the cellular and molecular pathways that help prevent the inheritance of mtDNA mutations to offspring by employing cutting-edge genetic technologies that the laboratory has recently developed in the germline of an animal model system. This Project will generate new knowledge in the area of mitochondrial genetics and evolution. Expected outcomes include the development of new theories for mtDNA inheritance, which should provide significant benefits for agricultural breeding programs and the interpretation of mtDNA inheritance patterns in the human population.Read moreRead less
To imitate or innovate: A new look at children's social learning strategies. Children learn many important things by copying others. But how do we best facilitate this where it’s culturally appropriate or encourage innovation to support more general learning? This developmental psychology project aims to provide answers, using novel experiments and comparisons of different cultural groups to show how children acquire skills while becoming valued community members. Expected outcomes include the r ....To imitate or innovate: A new look at children's social learning strategies. Children learn many important things by copying others. But how do we best facilitate this where it’s culturally appropriate or encourage innovation to support more general learning? This developmental psychology project aims to provide answers, using novel experiments and comparisons of different cultural groups to show how children acquire skills while becoming valued community members. Expected outcomes include the refinement of core developmental psychology theory, introduction of new experimental techniques, and strengthening of international collaborations. This should provide significant benefits to educators, policy makers, parents and those invested in understanding and improving the inter-generational transmission of knowledge.Read moreRead less
Imitation learning in infancy. We copy others all the time, to learn new skills and to connect socially and emotionally with those around us. But where does this ability to imitate come from? This is a long-standing question in developmental psychology that the proposed project aims to answer. Using a unique combination of EMG and behavioural observations, this project will chart infants’ imitation skills from birth through the first year of life, and test whether infants learn to imitate from ....Imitation learning in infancy. We copy others all the time, to learn new skills and to connect socially and emotionally with those around us. But where does this ability to imitate come from? This is a long-standing question in developmental psychology that the proposed project aims to answer. Using a unique combination of EMG and behavioural observations, this project will chart infants’ imitation skills from birth through the first year of life, and test whether infants learn to imitate from watching themselves and being imitated by others. The new knowledge arising from this research will clarify the origins of our uniquely human sociality. The outcomes should also enable earlier identification of developmental problems and provide novel avenues for intervention.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Open(ing up) goals in physical activity: What works, when, and for whom? This project aims to advance knowledge of open goals as a new goal-setting approach to optimise the adoption and maintenance of physical activity among insufficiently active individuals. This project expects to generate substantive insights into the mechanisms that explain why, when, and for whom open goals are particularly beneficial in this population. Expected outcomes include a theory of open goals that will inform phys ....Open(ing up) goals in physical activity: What works, when, and for whom? This project aims to advance knowledge of open goals as a new goal-setting approach to optimise the adoption and maintenance of physical activity among insufficiently active individuals. This project expects to generate substantive insights into the mechanisms that explain why, when, and for whom open goals are particularly beneficial in this population. Expected outcomes include a theory of open goals that will inform physical activity promotion efforts, with the potential for broad population-level dissemination and scale-up. Significant benefits include the ability to set physical activity goals that are enjoyable and intrinsically motivating to pursue, while also avoiding detrimental effects of current practice (eg high failure rates).Read moreRead less
Gaining control of the future: The cognitive development of foresight. Because humans can anticipate their limitations, they can act in the present to shape their future for the better.
This project aims to chart four key developmental processes by which children gain this control over their future
outcomes. It will use novel experimental paradigms to map children’s growing ability to compensate for their limits
with strategic planning, and to improve their future capacities by acquiring new kno ....Gaining control of the future: The cognitive development of foresight. Because humans can anticipate their limitations, they can act in the present to shape their future for the better.
This project aims to chart four key developmental processes by which children gain this control over their future
outcomes. It will use novel experimental paradigms to map children’s growing ability to compensate for their limits
with strategic planning, and to improve their future capacities by acquiring new knowledge and innovating
technical solutions. The cognitive underpinnings of these critical behaviours are still poorly understood. This
project will therefore provide the essential empirical foundation for fostering the development of wiser, more
skilled, and more innovative young people.Read moreRead less
The developmental significance of sleep transition in early childhood. This project aims to advance understanding of sleep functioning as children transition from many naps, to one nap, then none. Through an intense, objective longitudinal study of sleep from age one to five years, the project seeks to examine the interplay of sleep, care environment and ongoing child development. The project is expected to deliver much needed evidence to address the controversy surrounding care practice in fami ....The developmental significance of sleep transition in early childhood. This project aims to advance understanding of sleep functioning as children transition from many naps, to one nap, then none. Through an intense, objective longitudinal study of sleep from age one to five years, the project seeks to examine the interplay of sleep, care environment and ongoing child development. The project is expected to deliver much needed evidence to address the controversy surrounding care practice in family and early childhood education and care contexts. The expected benefit for parents and educators is improved knowledge and confidence in supporting children’s sleep. The expected benefit for children is positive development, given the known impacts of sleep on ongoing learning, behaviour and health.Read moreRead less