Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new know ....Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new knowledge that will challenge current concepts of mammalian growth control. The outcomes will enhance Australia's international reputation in the fields of physiology, immunology and developmental biology. Read moreRead less
New genetic mechanisms linking flowering, growth habit and yield in legumes. This project aims to investigate the genetic control of flowering and flowering-related traits in legumes, an important group of crop plants. The regulation of flowering by environmental factors has a major influence on plant yield and is important for adaptation in natural and agricultural settings. However, it is poorly understood at the molecular level. This project aims to use induced genetic variation and transcrip ....New genetic mechanisms linking flowering, growth habit and yield in legumes. This project aims to investigate the genetic control of flowering and flowering-related traits in legumes, an important group of crop plants. The regulation of flowering by environmental factors has a major influence on plant yield and is important for adaptation in natural and agricultural settings. However, it is poorly understood at the molecular level. This project aims to use induced genetic variation and transcriptome analysis to define new genes and genetic mechanisms through which flowering is regulated by day length and temperature, and to explore the molecular links between flowering and other developmental processes including seed development. This should extend our understanding of how plant architecture, reproduction and yield are regulated by the environment, and address several agronomic issues.Read moreRead less
The effects of maternal attachment, marital satisfaction and sensitivity to infants on infants attachment and adjustment: A longitudinal-structural equation study. This study will examine how family and attachment factors effect the adjustment of infant at 24 months of age. A longitudinal study, using structural equation method, will examine how maternal attachment and marital satisfaction when infants are 4 months of age will effect maternal parenting behaviors two months later, and how all thr ....The effects of maternal attachment, marital satisfaction and sensitivity to infants on infants attachment and adjustment: A longitudinal-structural equation study. This study will examine how family and attachment factors effect the adjustment of infant at 24 months of age. A longitudinal study, using structural equation method, will examine how maternal attachment and marital satisfaction when infants are 4 months of age will effect maternal parenting behaviors two months later, and how all three of these measures will effect infant attachment 6 months later. It will then examine how all four of these measures will effect the adjustment of infants 12 months later. The study will have important implications for early intervention and prevention of psychological problems in infants and children.Read moreRead less
Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professiona ....Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professionals to identify early those youth at risk of having poor psychological, health, and employment prospects post-school. The project will inform the development of intervention programs for young people and maximise their overall adjustment and well-being several years later.Read moreRead less
A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on th ....A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role this protein family may play in all animals. The findings are expected to provide key insights into the modification of growth factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of new strategies for interfering with insect development for pest control.Read moreRead less
Rapid motor responses in young and older adults. This proposal aims to contribute to our understanding of basic neural mechanisms mediating rapid motor actions across our lifespan. One in four Australians will be over the age of 65 by the year 2056. The project plans to investigate how changes in brain structure and function, as well as alterations in cognitive processing abilities that occur in older age, affect rapid choices between various alternative motor actions as well as our ability to s ....Rapid motor responses in young and older adults. This proposal aims to contribute to our understanding of basic neural mechanisms mediating rapid motor actions across our lifespan. One in four Australians will be over the age of 65 by the year 2056. The project plans to investigate how changes in brain structure and function, as well as alterations in cognitive processing abilities that occur in older age, affect rapid choices between various alternative motor actions as well as our ability to stop motor responses once they are planned. It plans to combine noninvasive brain stimulation with novel behavioural experiments and computational modelling techniques to develop fundamental new knowledge of the natural processes that characterise age-related changes in rapid motor actions.Read moreRead less
How do we cancel or modify movements? This collaborative project aims to improve our understanding of how movements are rapidly cancelled, or reprogrammed, based on visual cues. Using innovative computational models, non-invasive brain stimulation and recordings of muscle activity, the project aims to elucidate how our brains anticipate the possibility of having to cancel planned actions, and how this changes as a function of healthy ageing. The outcomes are expected to assist in the design of n ....How do we cancel or modify movements? This collaborative project aims to improve our understanding of how movements are rapidly cancelled, or reprogrammed, based on visual cues. Using innovative computational models, non-invasive brain stimulation and recordings of muscle activity, the project aims to elucidate how our brains anticipate the possibility of having to cancel planned actions, and how this changes as a function of healthy ageing. The outcomes are expected to assist in the design of neuromorphic technologies that mimic human brain function. The generated knowledge may also inform future research aimed at maintaining cognitive and motor function in the ageing workforce and treating conditions in which inhibitory control is compromised. Read moreRead less
The ageing brain: plasticity and training. This project will investigate how the capacity of a person's brain for reorganisation (plasticity) influences cognitive and motor function and training benefits in older adults. The findings will support new training initiatives to promote brain health and well-being across the lifespan.
Sibling influence on development of children with autism spectrum disorder. This project aims to investigate how typically-developing siblings affect the development of children with autism spectrum disorder (ASD). ASD involves difficulties with language, executive functions and social understanding. For typically-developing children, growing up with siblings gives an advantage in these cognitive functions. Yet little is known about how having siblings’ impacts on cognitive development of childr ....Sibling influence on development of children with autism spectrum disorder. This project aims to investigate how typically-developing siblings affect the development of children with autism spectrum disorder (ASD). ASD involves difficulties with language, executive functions and social understanding. For typically-developing children, growing up with siblings gives an advantage in these cognitive functions. Yet little is known about how having siblings’ impacts on cognitive development of children with ASD. The project intends to longitudinally explore the mechanisms of sibling impact in families with and without a child with ASD. The outcomes will deepen understanding of child development, providing an evidence base for effective interventions to increase child competence and aiming ultimately to reduce the social costs of ASD.Read moreRead less