Type 1 diabetes (T1D) is a major chronic disease affecting over 100,000 Australians. Its treatment and complications impose a significant burden on affected individuals and their families and on the health system. T1D occurs when the immune system attacks insulin-producing cells in the islet cells of the pancreas. The team has developed ways to identify at-risk people, defined immune and genetic causes of T1D and is undertaking prevention trials and Australia's first islet transplant program. Th ....Type 1 diabetes (T1D) is a major chronic disease affecting over 100,000 Australians. Its treatment and complications impose a significant burden on affected individuals and their families and on the health system. T1D occurs when the immune system attacks insulin-producing cells in the islet cells of the pancreas. The team has developed ways to identify at-risk people, defined immune and genetic causes of T1D and is undertaking prevention trials and Australia's first islet transplant program. Their multidisciplinary research is taking us closer to the prevention and cure of T1D.Read moreRead less
Determinants of Audio-Visual effects in degraded and non-degraded speech. Seeing a speaker's face can affect the perception of their speech in a number of ways. This project proposes a detailed comparison of factors that affect Audio-Visual (AV) facilitation of degraded speech detection and identification. Detection-based tasks should be more sensitive to signal based correlations whereas identification-based effects more sensitive to complementary information. The significance of the current pr ....Determinants of Audio-Visual effects in degraded and non-degraded speech. Seeing a speaker's face can affect the perception of their speech in a number of ways. This project proposes a detailed comparison of factors that affect Audio-Visual (AV) facilitation of degraded speech detection and identification. Detection-based tasks should be more sensitive to signal based correlations whereas identification-based effects more sensitive to complementary information. The significance of the current proposal is that it offers both a strategy and a connected series of experiments for determining key behavioural constraints on AV speech integration. Understanding AV interactions will build links between neurophysiological processes and coherent perception and have important implications for AV application.Read moreRead less
Development of an ultrasensitive assay for human prion proteins. The aim of this work is to enable the detection of prion proteins in human blood and other tissues. The assay system to be developed will detect much lower levels of these disease-causing proteins than is possible at present; it will be more rapid and will measure prion protein levels more accurately than existing assays. The outcome of the work is expected to facilitate the production and certification of prion-free blood and bl ....Development of an ultrasensitive assay for human prion proteins. The aim of this work is to enable the detection of prion proteins in human blood and other tissues. The assay system to be developed will detect much lower levels of these disease-causing proteins than is possible at present; it will be more rapid and will measure prion protein levels more accurately than existing assays. The outcome of the work is expected to facilitate the production and certification of prion-free blood and blood products. Prions cause Bovine Spongiform Encaphalopathy and Creutzfeld Jacob Disease and attempts to control of these diseases would be greatly abetted by an optimal test for the disease-causing agent.Read moreRead less
The measurement and prediction of police interviewing performance and the dissemination of good practice through a distributive workplace learning system. This research aims to develop the first ever standardised measures of police interviewers' performance, focusing on interviews about sexual offences. Standardised measures are essential for quality control evaluation, identifying training needs, assigning workload, predicting case outcome and benchmarking organisation capabilities. By improvin ....The measurement and prediction of police interviewing performance and the dissemination of good practice through a distributive workplace learning system. This research aims to develop the first ever standardised measures of police interviewers' performance, focusing on interviews about sexual offences. Standardised measures are essential for quality control evaluation, identifying training needs, assigning workload, predicting case outcome and benchmarking organisation capabilities. By improving the quality of police interviews about sexual offences, this research will improve the reporting, prosecution and conviction rates of sexual offences, which will have a deterrent effect on potential offenders. Further, this research will reduce the stress of witnesses and suspects involved in the legal process and reduce burnout of police interviewers by increasing competency and job satisfaction.Read moreRead less
The RGG/RG motif as an RNA chaperone: advancing CRISPR-Cas RNA technology. This project investigates the way in which protein molecules interact effectively with RNA molecules and also aims to enhance the CRISPR-Cas13a system for RNA detection. Innovative approaches will be used to test the role of a particular protein motif, called the RGG/RG motif, in remodelling RNA structure and enhancing the Cas13a protein. This knowledge is expected to shift our understanding of protein-RNA interactions th ....The RGG/RG motif as an RNA chaperone: advancing CRISPR-Cas RNA technology. This project investigates the way in which protein molecules interact effectively with RNA molecules and also aims to enhance the CRISPR-Cas13a system for RNA detection. Innovative approaches will be used to test the role of a particular protein motif, called the RGG/RG motif, in remodelling RNA structure and enhancing the Cas13a protein. This knowledge is expected to shift our understanding of protein-RNA interactions that are fundamental to almost every aspect of cell biology. The project is intended to benefit Australia through contributing to fundamental knowledge in the field, facilitating the development of new CRISPR-Cas biotechnologies for RNA detection and through the training of young researchers in frontier technologies. Read moreRead less
De Novo Mutations And The Pathogenesis Of Childhood-onset Autoimmune Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,406,510.00
Summary
This project aims to reveal the gene abnormalities that cause devastating autoimmune diseases to develop in some children, such as Type 1 diabetes, juvenile arthritis and autoimmune destruction of blood cells. The project will use new technologies to identify alterations in the DNA sequence of a child compared to either of their parents, and to test suspicious DNA alterations in laboratory mice in order to understand the gene effects and evaluate new treatments.
A longitudinal study of the interaction of home and school language in three Aboriginal communities. The importance of language skills cannot be underestimated, and contribute to 'a healthy start to life'. In multilingual Indigenous communities, children must negotiate the complexities of different languages used for different purposes. This project will provide detailed insights into how children manage differences between home and school language, the kinds of problems they encounter when the ....A longitudinal study of the interaction of home and school language in three Aboriginal communities. The importance of language skills cannot be underestimated, and contribute to 'a healthy start to life'. In multilingual Indigenous communities, children must negotiate the complexities of different languages used for different purposes. This project will provide detailed insights into how children manage differences between home and school language, the kinds of problems they encounter when they enter the school system, and how their languages develop over the first four crucial years of school which provide the foundation for the children's future education. Their ability to manage the language of school underpins their ability to lead successful and engaged lives as adults. Read moreRead less
The future of the Pacific: youth leadership and civic engagement. This project aims to investigate how youth in the Pacific develop and demonstrate the forms of leadership and civic engagement needed for positive outcomes for their countries. New knowledge is expected to be generated about what influences Pacific youth to engage with the profound challenges facing their region, through Pacific-wide research and three case studies using participatory and collaborative methodologies. Expected outc ....The future of the Pacific: youth leadership and civic engagement. This project aims to investigate how youth in the Pacific develop and demonstrate the forms of leadership and civic engagement needed for positive outcomes for their countries. New knowledge is expected to be generated about what influences Pacific youth to engage with the profound challenges facing their region, through Pacific-wide research and three case studies using participatory and collaborative methodologies. Expected outcomes include interdisciplinary contributions to Pacific and youth studies and applied outputs. This should provide significant benefits including enhanced capacity for governments, development agencies and donors to develop policy and programming measures to nurture the future leadership of the Pacific region. Read moreRead less
Building bio-inspired smart nanochannels for virus detection. This project aims to harness high-precision silicon nanofabrication methods to create the next generation of bio-inspired viral biosensors. The new technology would enable prompt, cost-efficient, and accurate detection of virus contamination of our water and food supplies. The project plans to fabricate arrays of parallel double-layered nanochannels in silicon via templated etching, with surface functionalisation to display receptors. ....Building bio-inspired smart nanochannels for virus detection. This project aims to harness high-precision silicon nanofabrication methods to create the next generation of bio-inspired viral biosensors. The new technology would enable prompt, cost-efficient, and accurate detection of virus contamination of our water and food supplies. The project plans to fabricate arrays of parallel double-layered nanochannels in silicon via templated etching, with surface functionalisation to display receptors. These nanochannels are designed to act as size-selective filters for electrochemical and electrochemiluminescence sensing. The project plans to explore innovative signal amplification and multiplexing capabilities for ultrasensitive detection of norovirus and bacteriophages.Read moreRead less