I am a neurochemist-clinical research scientist investigating the interaction between, in particular, brain monoaminergic activity, autonomic function and physiological responses. My studies are largely focussed on determining the aetiology and consequenc
Depressive Illness And The Heart: Identifying The Relation Between Affective Disorders And Coronary Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$503,625.00
Summary
Major depression is ranked fourth among the 10 leading causes of the global burden of disease and, if epidemiological projections are correct, by 2020 it will reach second place. Patients with depression are at increased risk of developing coronary heart disease. This elevated risk is independent of conventional risk factors such as smoking, obesity, hyperlipidaemia, diabetes and hypertension. Also conclusively demonstrated is the adverse effect of depression in patients following myocardial inf ....Major depression is ranked fourth among the 10 leading causes of the global burden of disease and, if epidemiological projections are correct, by 2020 it will reach second place. Patients with depression are at increased risk of developing coronary heart disease. This elevated risk is independent of conventional risk factors such as smoking, obesity, hyperlipidaemia, diabetes and hypertension. Also conclusively demonstrated is the adverse effect of depression in patients following myocardial infarction (MI), which materially increases mortality. The mechanism of increased cardiac risk attributable to depressive illness is at present uncertain but activation of the sympathetic nervous system, exaggerated platelet reactivity and-or altered baroreflex function are likely to be of prime importance. Preliminary data from our laboratory indicates that whole body and cardiac sympathetic nervous activity and cardiac baroreflex sensitivity are modified following antidepressant therapy. Identifying the underlying neurochemical mechanisms responsible for alterations in affective behaviour, and quantifying cardiac and whole body sympathetic activity directly and indirectly, and testing whether therapeutic and behavioural interventions can influence brain neurotransmitter turnover and modify cardiac sympathetic tone, platelet reactivity, and baroreflex function in a fashion likely to reduce cardiac risk, will be an important step forward in alleviating the burden of depressive illness on the community.Read moreRead less
An Investigation Of The Role Of Gene-environment Interactions And Epigenetics In Depression: Nature Combined With Nurture.
Funder
National Health and Medical Research Council
Funding Amount
$337,602.00
Summary
Depression is one of the biggest public health problems, yet the causes remain largely unknown. This study aims to determine how environmental factors can combine with particular genes to increases an individual’s risk of depression. Environmental factors can also cause modifications to genes which can affect an individual’s health. This study will thus also examine whether women with post-natal depression and their children have different gene modifications than those without depression.
The Diamond Cohort Study- Examining Depressive Symptoms In Primary Care
Funder
National Health and Medical Research Council
Funding Amount
$570,886.00
Summary
Depression is the single largest cause of disability for people in Australia. It is mainly managed in general practice-primary care, yet many people experiencing depression go unrecognised by their family doctor or general practitioner (GP). Some people, even when given treatment, remain depressed. Guides on how to manage depression have been mainly based upon people attending psychiatrists and hospitals. In addition, there have been a number of large studies overseas testing new ways of helping ....Depression is the single largest cause of disability for people in Australia. It is mainly managed in general practice-primary care, yet many people experiencing depression go unrecognised by their family doctor or general practitioner (GP). Some people, even when given treatment, remain depressed. Guides on how to manage depression have been mainly based upon people attending psychiatrists and hospitals. In addition, there have been a number of large studies overseas testing new ways of helping people with depression. Unfortunately, they do not seem any better than usual care by a GP. We are currently funded by the NHMRC for diamond 1 to follow 800 people to investigate the factors from the patient's and doctor's point of view that are likely to aid recovery from depression, and to detail the way in which people are cared for in the primary health care system. There is increasing research showing that depression is a chronic and relapsing condition and that a one-year follow-up, whilst longer than most previous studies, will capture only a small glimpse of the health service use and relapse patterns of the patients enrolled in our study. In this application, we request funding to continue to follow participants. diamond 2 aims to explore the patient characteristics and health service use patterns of patients who experience persistent major depression with patients who experience a single episode of depression within a 3-year period. We will use the data gathered to develop models that predict recovery-relapse-persistence of depression. Such models will enable us to develop guidelines and design interventions that better target those at risk of continuing and disabling illness. This work will be of international significance and has the potential to influence the entire primary mental health care system and contribute to substantial system change.Read moreRead less
Pubertal Timing, Brain Development And Mental Health In Adolescence
Funder
National Health and Medical Research Council
Funding Amount
$786,976.00
Summary
Early timing of puberty is known to be associated with future mental health problems. This study aims to investigate whether children who go through adrenarche (an earlier phase of maturation) early are at risk for poor mental health during adolescence, and whether abnormal brain development is responsible for linking early adrenarche and mental health outcomes. The results of this research will have implications for the early detection of children at risk for mental health problems.
The Diamond Cohort Study - Long Term Outcomes Of Depressive Symptoms In Primary Care
Funder
National Health and Medical Research Council
Funding Amount
$567,538.00
Summary
The diamond study follows what happens to almost 800 people with depressive symptoms whom attend general practice for care over 5 years of their life. This study will map the severity of depressive symptoms, life circumstances, use of health care services and treatments and allow us to understand factors associated with relapse and recovery from depression in order to improve care. This will assist us to develop models of care that better suit the needs of people experiencing depressive symptoms ....The diamond study follows what happens to almost 800 people with depressive symptoms whom attend general practice for care over 5 years of their life. This study will map the severity of depressive symptoms, life circumstances, use of health care services and treatments and allow us to understand factors associated with relapse and recovery from depression in order to improve care. This will assist us to develop models of care that better suit the needs of people experiencing depressive symptoms.Read moreRead less
Gaining Two-way Understanding Of Recovery From Chronic And Recurring Mental Disorders In FNQ Indigenous Communities.
Funder
National Health and Medical Research Council
Funding Amount
$110,519.00
Summary
Little is known about the rates of chronic and recurring mental illness in the Indigenous population, particularly in remote Indigenous communities. This research aims to document the extent of the problem and explore the factors that place individuals at risk of poorer mental health outcomes as well as those factors that promote resiliency and recovery in the face of such risk. In addition, the concept of recovery in mental illness will be expanded to include Indigenous views.
Mood Regulation Using Music: A Community Health Strategy For Improving Quality Of Life In People With Mild Dementia
Funder
National Health and Medical Research Council
Funding Amount
$601,540.00
Summary
This research aims to improve quality of life in people with dementia via community-based strategies for managing depression using music. The impetus comes from my prior research which shows that depression affects both the way people use music and its impact on the listener, a factor not considered in previous studies. Findings will lay the ground for development of an online tool for promoting effective self-regulation of mood with music for use by patients and caregivers in multiple settings.
Interactions Between The Serotonin Transporter And Sympathetic Nervous Activation In Patients With Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
Funder
National Health and Medical Research Council
Funding Amount
$527,109.00
Summary
There is evidence that patients with major depressive disorder (MDD) are at increased risk of developing heart disease. While the mechanisms responsible remain unknown we have previously demonstrated that cardiac sympathetic nervous activity in patients with MDD follows a bimodal distribution, with values in some patients being extraordinarily high. In this project we will determine the physiological consequences of sympathetic activation in patients with MDD.