A Longitudinal Controlled Study To Prevent Early Childhood Caries From Ages 0-6 Years In A Disadvantaged Community In Queensland
Funder
National Health and Medical Research Council
Funding Amount
$695,788.00
Summary
Rampant dental decay in young children is very difficult to prevent. The study will follow a group of high risk children from birth to 6 years of age to test the effectiveness of antibacterial and remineralising agents to prevent dental decay. Our early results showed that these agents have good potential for removing decay-causing bacteria and preventing dental cavities. We expect our long term results will yield valuable information for dental prevention for young children worldwide.
Minimally Invasive Approach To Manage Early Childhood Caries In Aboriginal Preschoolers
Funder
National Health and Medical Research Council
Funding Amount
$1,488,220.00
Summary
The treatment of dental decay in young children is often undertaken in a hospital, which is costly and risky. A treatment approach tested among a non-Aboriginal preschool population in WA, using hand instruments only and without the use of local anaesthesia, showed nearly a ten-fold reduction in the need for specialist dental care. This study will test the effectiveness of dental treatment of preschool children in rural and remote Aboriginal communities, using the alternative approach.
Genetic Dissection Of The Biogenesis And Function Of Type IV Fimbriae Of Pseudomonas Aeruginosa
Funder
National Health and Medical Research Council
Funding Amount
$407,545.00
Summary
Pseudomonas aeruginosa is a common bacterium which causes serious life-threatening infections of individuals with cystic fibrosis, AIDS or who have suffered severe burns or are undergoing cancer chemotherapy. This pathogen, and a number of other important infectious bacteria use surface filaments, called fimbriae, like grappling hooks to attach to the cells of the body and to move across host tissues. These fimbriae are produced in response to environmental conditions, and are assembled by a pro ....Pseudomonas aeruginosa is a common bacterium which causes serious life-threatening infections of individuals with cystic fibrosis, AIDS or who have suffered severe burns or are undergoing cancer chemotherapy. This pathogen, and a number of other important infectious bacteria use surface filaments, called fimbriae, like grappling hooks to attach to the cells of the body and to move across host tissues. These fimbriae are produced in response to environmental conditions, and are assembled by a process that is also used in the export of toxins and other pathogenic molecules. This project will characterise genes which specify and control this system, as a means to design better treatments against such bacteria, many of which are resistant to antibiotic treatment.Read moreRead less
Sealing Ability Of Adhesive Restorations In Caries And Non-caries Affected Teeth.
Funder
National Health and Medical Research Council
Funding Amount
$46,081.00
Summary
Dental fillings are used in treating tooth decay. Tooth coloured materials have become more common than metal fillings. A factor in determining the effectiveness of these adhesive restorations is analysing the bond strength between the filling and tooth. A poor bond between the restorative material and tooth is likely to produce problems such as tooth sensitivity and recurrent decay. We intend to investigate the sealing ability of adhesive restorations to carious affected teeth and sound teeth.
Methods To Improve Detail Reproduction Of Elastic Impression Materials
Funder
National Health and Medical Research Council
Funding Amount
$96,656.00
Summary
If a dental prosthesis is to fit precisely in the mouth, an accurate impression must be taken of the teeth and surrounding tissues. This research aims to evaluate variable surface conditions which may be taken into consideration to achieve an accurate impression, such as moisture, temperature, and the presence of contaminants. Although any distortions as a result of material interactions would be limited to the surface interface, inaccuracies here may ultimately compromise treatment success.
Analysis Of A Chemosensory Complex That Controls Twitching Motility And Virulence In Pseudomonas Aeruginosa
Funder
National Health and Medical Research Council
Funding Amount
$346,250.00
Summary
Pseudomonas aeruginosa is a common bacterium which causes serious life-threatening infections of individuals with cystic fibrosis, AIDS or who have suffered severe burns or are undergoing cancer chemotherapy. Infection by this pathogen requires the controlled expression of a large number of virulence factors including extracellular enzyme, toxins and structures for the attachment and colonisation of host tissues. We have identified a complex multicomponent regulatory system which coordinates the ....Pseudomonas aeruginosa is a common bacterium which causes serious life-threatening infections of individuals with cystic fibrosis, AIDS or who have suffered severe burns or are undergoing cancer chemotherapy. Infection by this pathogen requires the controlled expression of a large number of virulence factors including extracellular enzyme, toxins and structures for the attachment and colonisation of host tissues. We have identified a complex multicomponent regulatory system which coordinates the expression of many of the virulence determinants of this pathogen. This project aims to dissect the intermolecular interactions and signalling events which input into, occur within, and output from this regulatory system. This knowledge will provide a platform for developing rational strategies for the production of new antimicrobials for fighting infections by this and related pathogens.Read moreRead less
Does Teriparatide Reverse Osteonecrosis Of The Jaw In Patients With Cancer? A Randomised, Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$357,412.00
Summary
Osteonecrosis of the jaw (ONJ) is debilitating and associated with drugs that increase bone strength and reduce the bone remodeling rate (bisphosphonates or denosumab). Up to 15% of patients with bone marrow cancer and 1 out of 952 patients with osteoporosis treated with bisphosphonates may get ONJ. This 8-week trial of subcutaneous teriparatide (a hormone that forms new bone) or placebo injections aims to promote resolution of ONJ, measured clinically and by x-ray, and improve quality of life.