A Longitudinal Controlled Study To Prevent Early Childhood Caries From Ages 0-6 Years In A Disadvantaged Community In Queensland
Funder
National Health and Medical Research Council
Funding Amount
$695,788.00
Summary
Rampant dental decay in young children is very difficult to prevent. The study will follow a group of high risk children from birth to 6 years of age to test the effectiveness of antibacterial and remineralising agents to prevent dental decay. Our early results showed that these agents have good potential for removing decay-causing bacteria and preventing dental cavities. We expect our long term results will yield valuable information for dental prevention for young children worldwide.
Minimally Invasive Approach To Manage Early Childhood Caries In Aboriginal Preschoolers
Funder
National Health and Medical Research Council
Funding Amount
$1,488,220.00
Summary
The treatment of dental decay in young children is often undertaken in a hospital, which is costly and risky. A treatment approach tested among a non-Aboriginal preschool population in WA, using hand instruments only and without the use of local anaesthesia, showed nearly a ten-fold reduction in the need for specialist dental care. This study will test the effectiveness of dental treatment of preschool children in rural and remote Aboriginal communities, using the alternative approach.
Does Teriparatide Reverse Osteonecrosis Of The Jaw In Patients With Cancer? A Randomised, Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$357,412.00
Summary
Osteonecrosis of the jaw (ONJ) is debilitating and associated with drugs that increase bone strength and reduce the bone remodeling rate (bisphosphonates or denosumab). Up to 15% of patients with bone marrow cancer and 1 out of 952 patients with osteoporosis treated with bisphosphonates may get ONJ. This 8-week trial of subcutaneous teriparatide (a hormone that forms new bone) or placebo injections aims to promote resolution of ONJ, measured clinically and by x-ray, and improve quality of life.
How Are Periodontal Disease And Rheumatoid Arthritis Inter-related?
Funder
National Health and Medical Research Council
Funding Amount
$563,262.00
Summary
Periodontal (gum) disease and rheumatoid arthritis are two of the most common chronic inflammatory diseases affecting humans. These two diseases have remarkably similar patterns of tissue destruction. It is possible that chronic periodontitis may prime or predispose susceptible individuals to developing rheumatoid arthritis. Treatment of periodontal disease may help reduce the severity of rheumatoid arthritis.
Intergenerational Change In Oral Health In Australia
Funder
National Health and Medical Research Council
Funding Amount
$566,827.00
Summary
Australia's population is ageing and Australians are retaining more teeth in later life. It is expected that as life expectancy increases, more years of life are spend in good health, with disease and disability being postponed to later years of life. No evidence is available to test the compression of morbidity hypothesis in relation to oral health in older Australians. This study will test whether these changes have resulted in more years in good oral health in an elderly population.