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Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, ....Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.Read moreRead less
A critical public health examination of complementary self-medication in later life in indigenous, non-indigenous and CALD communities. This project aims to provide the first in-depth coordinated critical public health examination of an unregulated and 'covert' area of health and treatment seeking behaviour - complementary self-medication (CAM SM) use in later life. It will focus on healthy ageing and living with chronic illness and draw upon fieldwork with Indigenous, non-Indigenous and cultura ....A critical public health examination of complementary self-medication in later life in indigenous, non-indigenous and CALD communities. This project aims to provide the first in-depth coordinated critical public health examination of an unregulated and 'covert' area of health and treatment seeking behaviour - complementary self-medication (CAM SM) use in later life. It will focus on healthy ageing and living with chronic illness and draw upon fieldwork with Indigenous, non-Indigenous and culturally and linguistically diverse (CALD) communities. This project aims to identify the challenges of, and possibilities for, 'covert' CAM SM use in later life. It will provide an evidence-base to inform safe, effective care and policy for older Australians and generate novel analyses to provide significant advances and new directions for public health scholarship with regards to chronic illness and community health in later life.Read moreRead less
Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are ....Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are overpriced relative to effectiveness. Not funding medicines may disadvantage patients in whom the medicines are effective. Methods to enable access to medicines while reducing uncertainty will offer significant benefit to patients, clinicians and taxpayers. Read moreRead less
A community-based approach to the problem of underage drinking. This project will aim to reduce the frequency and amount of alcohol consumption, and alcohol-related harms, among young people aged 12-17 years by addressing social norms regarding underage alcohol consumption. Using a multi-component intervention it will engage the Illawarra community in strategies to encourage and empower young people not to drink.
Healthy infant and young child diets from sustainable first-food systems. Breastfeeding, breastmilk and other first foods consumed during infancy and early childhood, are currently neglected in food systems research and policy action, despite their importance to establishing life-long dietary preferences, health and sustainability. This project addresses this gap, by developing a novel 'first-food systems' conceptual framework, describing global, regional and national changes in infant and young ....Healthy infant and young child diets from sustainable first-food systems. Breastfeeding, breastmilk and other first foods consumed during infancy and early childhood, are currently neglected in food systems research and policy action, despite their importance to establishing life-long dietary preferences, health and sustainability. This project addresses this gap, by developing a novel 'first-food systems' conceptual framework, describing global, regional and national changes in infant and young child diets, and generating end-user knowledge to generate political commitment for early-life nutrition. This research will deliver economic, social and environmental benefits for Australia and international communities, by helping to reduce the ill-health and environmental harms linked with unhealthy early-life diets.Read moreRead less
Improving health and criminal justice outcomes among Australia's offender population using a multi-disciplinary, all of government approach. Offender populations comprise some of the most marginalised and socially excluded individuals in society. With this comes poor health, engagement in risk behaviours and reduced social outcomes. Violence, mental health, infectious diseases, and substance misuse are all characteristics of offender populations and have a huge impact on the wider community. The ....Improving health and criminal justice outcomes among Australia's offender population using a multi-disciplinary, all of government approach. Offender populations comprise some of the most marginalised and socially excluded individuals in society. With this comes poor health, engagement in risk behaviours and reduced social outcomes. Violence, mental health, infectious diseases, and substance misuse are all characteristics of offender populations and have a huge impact on the wider community. The research programme linked to this application will collect new information aimed at reducing this impact and also develop a much needed intervention to reduce violent reoffending. Indigenous people are over-represented in the Australian prison system and will benefit from the work programme associated with this application.Read moreRead less
Epidemiologic and economic approaches to reduce the burden of depression and related chronic diseases in the workforce. Employers and governments alike are increasingly recognising that mental health impacts productivity, but many employers remain uninformed about the magnitude of the productivity consequences and what they can do about it. The ongoing individual and economic burden from depressive and anxiety disorders among working adults necessitates multi-disciplinary solutions. This series ....Epidemiologic and economic approaches to reduce the burden of depression and related chronic diseases in the workforce. Employers and governments alike are increasingly recognising that mental health impacts productivity, but many employers remain uninformed about the magnitude of the productivity consequences and what they can do about it. The ongoing individual and economic burden from depressive and anxiety disorders among working adults necessitates multi-disciplinary solutions. This series of studies will provide nationally and internationally significant new data to both inform understanding of the magnitude of the problem, and to provide cost-effective solutions to addressing it. Findings will directly inform workplace mental health promotion and prevention activities and be usable by employers, clinicians, and governments.Read moreRead less
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.
Stigma and discrimination and their detrimental impact on social inclusion and health and well-being. Experiencing stigma and discrimination harms health and wellbeing, and prevents people from being fully included in society. This project will help us understand how to best reduce stigma and discrimination, and to protect people from their negative effects.
Tracking blood and blood products for a healthy start to life. This project will aim to coalesce multiple data sources to track blood and blood products from supply to recipient and improve safe and appropriate blood product transfusions for mothers and newborns. Tracking blood will assist in early identification of adverse outcomes. Identification of at-risk women and babies will allow early prevention and treatment.