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Failure modes in ceramic-based layer structures: Relevance to failure of dental crowns. With the aging of our population, issues concerning the lifetime of biological system are paramount to the quality of life and economic well being of our society. This project is closely linked to the development of prosthetic materials and structures that will improve performance and life of biomechanical devices, by providing better understanding to the mechanics of failure and failure origins of ceramic-ba ....Failure modes in ceramic-based layer structures: Relevance to failure of dental crowns. With the aging of our population, issues concerning the lifetime of biological system are paramount to the quality of life and economic well being of our society. This project is closely linked to the development of prosthetic materials and structures that will improve performance and life of biomechanical devices, by providing better understanding to the mechanics of failure and failure origins of ceramic-based dental crowns and restorations, and to develop materials that will withstand exacting conditions - in body fluids - over extended lifetimes. Crown replacement is by far the most widespread of all prosthetic procedures. This project promises to help bridge the gap between physical and medical science in Australia. Read moreRead less
Meso- and Macro-porous Bioactive Glasses for Bone-repairing. This project aims to use self-assembly and pore engineering at different length scales to fabricate novel bioactive glasses of highly ordered mesoporous structure. By precisely controlling the composition, size and volume of both mesopores and macropores, bioactive glasses with improved bone forming activities will be obtained. The successful synthesis of such bioactive glasses is expected to lead to the fundamental understanding of st ....Meso- and Macro-porous Bioactive Glasses for Bone-repairing. This project aims to use self-assembly and pore engineering at different length scales to fabricate novel bioactive glasses of highly ordered mesoporous structure. By precisely controlling the composition, size and volume of both mesopores and macropores, bioactive glasses with improved bone forming activities will be obtained. The successful synthesis of such bioactive glasses is expected to lead to the fundamental understanding of structure-bioactivity relationship, and new materials effective for tissue engineering. This will also open up new opportunities for other applications such as drug delivery, implanting.Read moreRead less
Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the ....Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the necessary interdisciplinary approach to generate a new product for patients in need of bone regeneration. Australia will benefit from the contribution to medical science, the development of a new device for rapid prototyping tissue engineering scaffolds, retain biomaterials research expertise, and generate new biomedical products.Read moreRead less
The mechanics of being human. This project will lead to far more detailed understanding of skull mechanics in our own lineage. Results will be of great interest to international scholars in both evolutionary and biomedical fields and help to establish a primary position for Australia in the rapidly expanding area of computer simulation of biological structure. Further development on our own established protocols for automated transfer of CT scan data into finite element models, which have alread ....The mechanics of being human. This project will lead to far more detailed understanding of skull mechanics in our own lineage. Results will be of great interest to international scholars in both evolutionary and biomedical fields and help to establish a primary position for Australia in the rapidly expanding area of computer simulation of biological structure. Further development on our own established protocols for automated transfer of CT scan data into finite element models, which have already improved speed, accuracy and realism, will take finite element analysis to a point at which it can be more readily applied to evolutionary, biomedical and safety design questions.Read moreRead less