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ASPREE is the largest clinical trial ever conducted in Australia and will determine whether daily low dose aspirin prevents disease in healthy older people. The study was well-funded initially but will require additional support to complete the vital final stage of data collection and analysis. This will enable the study to answer important questions about the benefits and risks of aspirin in this age group and its effect on disability free survival.
Centre Of Research Excellence In Cognitive Health: Evidence, Intervention And Population Modelling
Funder
National Health and Medical Research Council
Funding Amount
$2,499,872.00
Summary
Cognitive health is essential for productivity at all ages. Common chronic diseases such as diabetes, and risk factors such as smoking, can reduce cognitive function and increase risk of cognitive decline. Our Centre aims to build evidence about the things that impact on cognitive health and lead to cognitive decline; to develop methods of reducing cognitive decline; and to measure the impact of cognitive impairment at the national level to inform the government on costs and planning.
Addressing Evidence-practice Gaps In Chronic Disease Prevention And Control
Funder
National Health and Medical Research Council
Funding Amount
$709,931.00
Summary
Cardiovascular diseases are the leading causes of premature death and disability worldwide. Effective treatments for prevention and control of these conditions are available however their use remains far from optimal, in Australia and globally. My current and proposed research will develop and evaluate highly innovative solutions to reduce large evidence-practice gaps in healthcare delivery. These include task shifting to non-physician health workers and novel approaches to drug delivery.
Do Urban Green Spaces Help To Reduce Incidence Of Alzheimer's And Associated Risk Factors? Multilevel Longitudinal Study Of 267,153 Adults With 15 Years Of Follow-up
Funder
National Health and Medical Research Council
Funding Amount
$719,841.00
Summary
Green spaces (e.g. parks and tree canopy) may help reduce – and narrow socioeconomic inequities - in the risk of Alzheimer’s by improving mental health and cognition, promoting physical activity and social support, reducing social isolation, reducing depression, obesity, cardiometabolic disease risk and buffering harms from traffic-related air pollution. I will conduct the first large-scale longitudinal studies to examine this hypothesis across a 15-year timespan.
Bridging The Gap For Women With Gestational Diabetes: Supporting Prevention Of Type 2 Diabetes Through Improved Care Of A High Risk Group.
Funder
National Health and Medical Research Council
Funding Amount
$174,107.00
Summary
The strongest risk factor for women developing diabetes is having diabetes in pregnancy or Gestational Diabetes Mellitus (GDM). Roughly half of women with GDM develop diabetes so regular GDM screening is critical alongside healthy lifestyle support, which can prevent diabetes developing. General Practice (GP) is where these activities should occur but the extent of GP delivery varies. This project will support GP delivery of these activities to improve the health of these high-risk women.
Improving Early Recognition And Response To Symptoms In Acute Cardiovascular Events.
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
An important challenge facing cardiovascular public health is to improve access to treatment for acute events, like heart attacks and stroke, by improving public recognition and the initial response to symptoms. This research aims to extend the current understanding and to evaluate existing and test new interventions in this area. Outcomes from this research will inform the development of future campaigns and interventions aiming to improve symptom recognition and reduce delays in presenting to ....An important challenge facing cardiovascular public health is to improve access to treatment for acute events, like heart attacks and stroke, by improving public recognition and the initial response to symptoms. This research aims to extend the current understanding and to evaluate existing and test new interventions in this area. Outcomes from this research will inform the development of future campaigns and interventions aiming to improve symptom recognition and reduce delays in presenting to hospital for acute cardiovascular events.Read moreRead less
Optimising Primary Care Risk Profiling And Management Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$408,387.00
Summary
Dr Carrington's CDF will support her career progression in 4 areas of translational research: 1. Closing the gap in ATSI heart health – optimising management of heart disease in Central Australia 2. Supporting healthy regional communities - developing cost-effective risk reduction clinics 3. Coordinating the care of complex cardiac conditions – refining an electronic tool to optimise GP management 4. International heart health – develop an effective primary care model of risk reduction in Sub-Sa ....Dr Carrington's CDF will support her career progression in 4 areas of translational research: 1. Closing the gap in ATSI heart health – optimising management of heart disease in Central Australia 2. Supporting healthy regional communities - developing cost-effective risk reduction clinics 3. Coordinating the care of complex cardiac conditions – refining an electronic tool to optimise GP management 4. International heart health – develop an effective primary care model of risk reduction in Sub-Saharan AfricaRead moreRead less
A Multi-faceted Electronic Health Intervention To Prevent And Manage Vascular Disease In Australia
Funder
National Health and Medical Research Council
Funding Amount
$62,317.00
Summary
Heart disease and stroke are the leading cause of death and disability in Australia with Aboriginal and Torres Strait Islander people experiencing it at a far greater rate; however most can be prevented. Medical guidelines to prevent heart attacks and strokes are available to medical professionals, but they’re rarely used to their full potential. My research uncovers a new health intervention that will broadly improve the ability of primary care staff to prevent and manage heart disease and stro ....Heart disease and stroke are the leading cause of death and disability in Australia with Aboriginal and Torres Strait Islander people experiencing it at a far greater rate; however most can be prevented. Medical guidelines to prevent heart attacks and strokes are available to medical professionals, but they’re rarely used to their full potential. My research uncovers a new health intervention that will broadly improve the ability of primary care staff to prevent and manage heart disease and stroke.Read moreRead less
Assessing The Benefit Of Low Dose Aspirin In The Prevention Of Severe Sepsis.
Funder
National Health and Medical Research Council
Funding Amount
$391,880.00
Summary
Recent discoveries suggest that low doses of aspirin may save lives in patients with infection by limiting its severity. We will conduct a large-scale primary prevention study using daily low-dose aspirin to explore whether this widely used drug can safely prevent severe infection. This study is made possible by collaborative involvement in an existing Australian and USA funded study called ASPREE. Finding a treatment that helps prevent severe effects and outcomes of infection would be a major h ....Recent discoveries suggest that low doses of aspirin may save lives in patients with infection by limiting its severity. We will conduct a large-scale primary prevention study using daily low-dose aspirin to explore whether this widely used drug can safely prevent severe infection. This study is made possible by collaborative involvement in an existing Australian and USA funded study called ASPREE. Finding a treatment that helps prevent severe effects and outcomes of infection would be a major health advance.Read moreRead less
Stroke In Australia: Understanding Variation In Clinical Care And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Stroke is the major cause of death and disability. My ECF research project is designed to identify (1) factors that influence hospital readmissions (2) gaps in hospital care for specific groups who experience stroke using the largest national dataset (40+ hospitals, 17,000+ patients). These data will provide evidence for me to develop and test novel future interventions to reduce inequalities in health care access in order to reduce deaths and disability through improvements in stroke care.