Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
Biomarkers To Aid Clinical Trials For Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$13,179,875.00
Summary
Alzheimer’s disease and Parkinson’s disease continue to affect more Australians every year, due to an ageing population and the lack of effective drugs currently available. Whilst these diseases present with different symptoms, we’ve discovered that they share a common underlying feature; the inability to clear certain metals and proteins from the brain. Our program aims to explore these clearance pathways in the brain and identify new targets to help us better diagnose and treat these diseases.
Risk Factors, Early Diagnosis, And Effective Interventions For Neurocognitive Disorders
Funder
National Health and Medical Research Council
Funding Amount
$7,013,299.00
Summary
This program will focus on early detection of dementia, identification of novel risk factors, and development of new treatments, to help the burden of dementia in our community. It will build on three longitudinal studies – Memory and Ageing Study, Older Australian Twins Study and Sydney Centenarian Study, and three international consortia – COSMIC, STROKOG and ICC-Dementia, that the investigators have developed to achieve these aims. A prevention trial for post-stroke dementia is planned
Frontotemporal Dementia And Motor Neurodegenerative Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$11,583,107.00
Summary
Frontotemporal degeneration of the brain is a leading cause of morbidity. It is a pathologically heterogeneous group of rapidly-progressive disorders with behavioural, language and motor deficits. This research program brings together international leaders in clinical, pathological and biological research of these syndromes, aiming to fast track new knowledge and innovations to develop the necessary tools and therapies to effectively diagnose, manage and treat these disorders.
Frontotemporal Dementia And Motor Neurodegenerative Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$17,069,580.00
Summary
Frontotemporal degeneration of the brain is a leading cause of morbidity due to a pathologically heterogeneous, rapidly-progressive group of disorders with behavioural, language and motor deficits. Our internationally recognized team will continue to develop the necessary tools and therapies to effectively diagnose, manage and treat these disorders. Our focus in this program is to understand the unusual genetics underpinning these disorders, and to fast track any potential treatments.
Discovery And Translation Of Evidence For New Strategies To Combat Cardiovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$17,802,750.00
Summary
The Program brings together clinicians, epidemiologists and statisticians in a unique endeavour combating heart attack and stroke as well as diabetes and kidney disease, all of which are closely related, through “hardening of the arteries”. The Program will provide fresh evidence on innovative strategies for treating and preventing these disorders, as well as strategies for translating them into more effective health policy and improved clinical practice.
MOTOR IMPAIRMENT: Basic And Applied Human Neurophysiology
Funder
National Health and Medical Research Council
Funding Amount
$6,830,980.00
Summary
Motor Impairment results in physical disability in a wide range of debilitating diseases and health conditions. We will conduct a research program that will include both experimental investigations and clinical trials to identify optimal strategies for maximising physical functioning for people with weakness and fatigue, impaired sensation and balance, and contracture. In doing so, our program offers great scope for improving the health and quality of life for millions of Australians and substan ....Motor Impairment results in physical disability in a wide range of debilitating diseases and health conditions. We will conduct a research program that will include both experimental investigations and clinical trials to identify optimal strategies for maximising physical functioning for people with weakness and fatigue, impaired sensation and balance, and contracture. In doing so, our program offers great scope for improving the health and quality of life for millions of Australians and substantially reducing health care costs.Read moreRead less