An explainability oriented approach to manage dependent supply chain risks. This project aims to help supply chain companies model the impact on their operations by capturing the uncertainties impacting their upstream suppliers. In the current uncertain business environment, the project's outcome will benefit service-based industries to have an enhanced understanding of their operating environment and take decisions accordingly to avoid failures. This will significantly increase the productivity ....An explainability oriented approach to manage dependent supply chain risks. This project aims to help supply chain companies model the impact on their operations by capturing the uncertainties impacting their upstream suppliers. In the current uncertain business environment, the project's outcome will benefit service-based industries to have an enhanced understanding of their operating environment and take decisions accordingly to avoid failures. This will significantly increase the productivity of Australian service-based industries across different domains. The expected outcome is that it generates new knowledge by which risk managers of a focal company can conjointly consider risk identification/assessment with risk management analysis to develop explainable strategies for managing uncertainties. Read moreRead less
Predicting the value and use of urban land. This project aims to develop a comprehensive, robust and user-friendly set of modelling tools to predict land values more accurately. Accurate predictions of land values reduce state government revenue risks and improve resource management. The expected outcome of this project is the development of modelling tools which, can be used to study land use allocation, infrastructure delivery and government taxation revenue. This should provide significant be ....Predicting the value and use of urban land. This project aims to develop a comprehensive, robust and user-friendly set of modelling tools to predict land values more accurately. Accurate predictions of land values reduce state government revenue risks and improve resource management. The expected outcome of this project is the development of modelling tools which, can be used to study land use allocation, infrastructure delivery and government taxation revenue. This should provide significant benefits such as the development of new econometric theory, advanced computational methods and evidence-based guidelines for policymakers.Read moreRead less
Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using pre-clinical models to identify and characterize a new brain system implicated in drug-seeking.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Salt (sodium) is an essential electrolyte. Our convincing and complementary findings provide compelling evidence for a link between evolutionarily ancient “instincts” and substance abuse. This proposal is translational, including studies in opiate dependent humans. Our studies will establish how and where in the brain endogenous opioids are implicated in the gratification of salt appetite, how salt appetite is altered in opiate dependency and if salt appetite recovers following opiate withdrawal
Insect-inspired flapping wing robots: autonomous flight control systems. This project aims to design a novel control scheme for insect-inspired, flapping-wing, micro aerial vehicles. This type of micro aerial vehicle has complex, periodic, time-varying and inherently unstable dynamics, which are practically challenging to model and implement in hardware. This project will design energy-based automatic stabilization and task-dependent control, and develop the insect-inspired platform for testing ....Insect-inspired flapping wing robots: autonomous flight control systems. This project aims to design a novel control scheme for insect-inspired, flapping-wing, micro aerial vehicles. This type of micro aerial vehicle has complex, periodic, time-varying and inherently unstable dynamics, which are practically challenging to model and implement in hardware. This project will design energy-based automatic stabilization and task-dependent control, and develop the insect-inspired platform for testing nonlinear control strategies. The expected outcomes will include new system and control theories, concepts, principles and technologies in controller design that can provide reliable flight control for bio-inspired, flapping-wing systems.Read moreRead less
Complexity-manageable methodologies and efficient computational tools for analysis and design of large-scale systems. The tools to be developed in this project have impact on a broad range of disciplines, including system analysis, feedback control technology, signal processing, communication network, and information theory. Practically, the success of this project will create cutting edge technologies applicable to design and management of important infrastructures of the modern society such as ....Complexity-manageable methodologies and efficient computational tools for analysis and design of large-scale systems. The tools to be developed in this project have impact on a broad range of disciplines, including system analysis, feedback control technology, signal processing, communication network, and information theory. Practically, the success of this project will create cutting edge technologies applicable to design and management of important infrastructures of the modern society such as communication networks, transportation systems, electrical power grids, and collaborative intelligent machines, and water distribution networks. Success of this project will bring novel methodologies and computational tools which help engineers to systematically design and validate the performance of their engineering systems.Read moreRead less
Robustness Analysis and Control Design of Distributed and Networked Systems. The theory and computational tools to be developed in this project have impact on a broad range of areas, including various engineering disciplines, biology, and medical and environmental sciences. In terms of practical interests, this project will create cutting edge technologies which are applicable to important infrastructures of the modern society such as communication networks, transportation systems, electrical po ....Robustness Analysis and Control Design of Distributed and Networked Systems. The theory and computational tools to be developed in this project have impact on a broad range of areas, including various engineering disciplines, biology, and medical and environmental sciences. In terms of practical interests, this project will create cutting edge technologies which are applicable to important infrastructures of the modern society such as communication networks, transportation systems, electrical power grids, collaborative intelligent machines, and water distribution networks. Read moreRead less
Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also ....Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also have significant spillover benefits into other complex system domains, where computational tools can be used to aid in design leading to high embedded-IP products for Australian industry. Furthermore, the proposal encompasses a strong research training aspect, with graduates exposed to leading edge industry and academia.Read moreRead less
Human-Robot Co-Evolution: Achieving the full potential of future workplaces. Physical human-robot systems are widely used to amplify the capability of human labourers and improve ergonomics in the workplace. This project aims to develop robot controllers that shape the co-evolution of these systems. Through physical human-robot interaction studies it will generate new knowledge of how humans adapt to working with robots, which will then be incorporated into the robot controller design. Expected ....Human-Robot Co-Evolution: Achieving the full potential of future workplaces. Physical human-robot systems are widely used to amplify the capability of human labourers and improve ergonomics in the workplace. This project aims to develop robot controllers that shape the co-evolution of these systems. Through physical human-robot interaction studies it will generate new knowledge of how humans adapt to working with robots, which will then be incorporated into the robot controller design. Expected outcomes include a better understanding of human adaptation and a systematic approach to shaping human-robot interaction over time. This should provide significant benefits across different skill and labour-intensive industries in Australia, such as improved worker productivity and safer human-robot collaboration.Read moreRead less