The Role Of Copper In Ubiquitin-dependent Protein Degradation In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$588,622.00
Summary
Ubiquitin’s are small proteins that tag other proteins in a process known as “Ubiquitination”. Often this is to target them for degradation once they are no longer needed i.e. to take out the rubbish. This process is disrupted in Alzheimer’s disease (AD), which may contribute to the disease. This project aims to find out if copper, an essential metal for life, is required for this process. Drugs that are designed to deliver copper to brain cells have been effective in small AD clinical trials.
Role of organic matter in soil pH change in agro-ecosystems. Over 50 million hectares of arable lands in Australia are affected by soil acidity. Acidity-affected lands continue to expand due to the ongoing process of acidification under current farming practices. The project will provide new knowledge essential for the improved use and management of organic matter to minimize or reverse soil acidification and increase carbon sequestration in farming systems. The associated reduction of soil aci ....Role of organic matter in soil pH change in agro-ecosystems. Over 50 million hectares of arable lands in Australia are affected by soil acidity. Acidity-affected lands continue to expand due to the ongoing process of acidification under current farming practices. The project will provide new knowledge essential for the improved use and management of organic matter to minimize or reverse soil acidification and increase carbon sequestration in farming systems. The associated reduction of soil acidification will also minimise the negative impact of nutrient and water losses on the environment. Growers will benefit from the project through improved soil fertility and crop production, and sustainable land use. Read moreRead less
Use of Distichlis spicata for sustainable forage production on saline land to manage dryland salinity. Sustainable and productive use of salt-affected lands is a priority for many farmers. This project aims to develop management strategies that optimise yield, water use and nutritive value of Distichlis spicata (a salt-tolerant grass) forage on salinised lands, and to understand how this forage species affects the salt cycle, water use and fertility improvement of saline soils.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989062
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Airborne hyper-spectral scanning for advanced monitoring and assessment of vegetation and water properties. The proposed infrastructure will give Australian researchers the most advanced capabilities available world-wide in airborne remote sensing of the environment. By combining hyper-spectral scanning, with full wave-form resolving Light Detection and Ranging (LIDAR), microwave scanning and sythetic aperture RADAR, flown simultaneously on the most cost-efficient and technologically advanced re ....Airborne hyper-spectral scanning for advanced monitoring and assessment of vegetation and water properties. The proposed infrastructure will give Australian researchers the most advanced capabilities available world-wide in airborne remote sensing of the environment. By combining hyper-spectral scanning, with full wave-form resolving Light Detection and Ranging (LIDAR), microwave scanning and sythetic aperture RADAR, flown simultaneously on the most cost-efficient and technologically advanced research aircraft, it will be possible to assess and monitor a wide range of parameters not accessible to airborne methods before.Read moreRead less
Improving water use efficiency of grapevine production in the Great Western region using effluent water and soil amelioration practices. Irrigation of vineyards with municipal wastewater is a desirable option for the viticulturists of the Great Western region of Victoria, but only if vineyard soil structure is not adversely affected. This project will (1) study the impact of dissolved chemicals in the waste water on the structure of the local sandy soils; (2) model the data to enhance understand ....Improving water use efficiency of grapevine production in the Great Western region using effluent water and soil amelioration practices. Irrigation of vineyards with municipal wastewater is a desirable option for the viticulturists of the Great Western region of Victoria, but only if vineyard soil structure is not adversely affected. This project will (1) study the impact of dissolved chemicals in the waste water on the structure of the local sandy soils; (2) model the data to enhance understanding of the key chemical and physical mechanisms controlling grey water impact in heterogeneous environments. The resulting predictive tools will have direct application in the Great Western region's vineyards, and for irrigation of grey water in vineyards across Ausralia.Read moreRead less
Special Research Initiatives - Grant ID: SR0354511
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Soil Acidification, the Environment and Production. Soil acidification affects 50% of Australia's agricultural land and is the most important economic constraint to agricultural. In addition, major external offsite impacts include greenhouse gas emissions, reduced stream and ground water health, reduced biodiversity, increased salinity and waterlogging and infrastructure damage. The aim of this network is to quantify the acidification processes and the connection of these processes to the offsit ....Soil Acidification, the Environment and Production. Soil acidification affects 50% of Australia's agricultural land and is the most important economic constraint to agricultural. In addition, major external offsite impacts include greenhouse gas emissions, reduced stream and ground water health, reduced biodiversity, increased salinity and waterlogging and infrastructure damage. The aim of this network is to quantify the acidification processes and the connection of these processes to the offsite impacts. This will lead to development of strategic plans for acidified and potential acid soils and associate offsite impacts, as well as identifying knowledge gaps and building research and policy synergies. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560895
Funder
Australian Research Council
Funding Amount
$854,354.00
Summary
A new-generation gas-source radiocarbon system for integrated environmental and archaeological research. An ultra-sensitive radiocarbon analysis system, proposed here, is central to new, multi-institution research into past fluctuations of Australia's climate, natural resources and ecosystems. Focussed on the 40,000 years of human presence, the research is an integrated approach to changes of earth systems in the Australian region.The equipment is a single-stage accelerator mass spectrometer (SS ....A new-generation gas-source radiocarbon system for integrated environmental and archaeological research. An ultra-sensitive radiocarbon analysis system, proposed here, is central to new, multi-institution research into past fluctuations of Australia's climate, natural resources and ecosystems. Focussed on the 40,000 years of human presence, the research is an integrated approach to changes of earth systems in the Australian region.The equipment is a single-stage accelerator mass spectrometer (SSAMS) with an innovative gas-fed ion source and automated gas-handling system, with simpler processing and smaller samples than present AMS facilities. Future developments include automated multi-sample handling and coupling to microprobe and chromatographic analysers for microscale radiocarbon analysis of complex substances.Read moreRead less
Ecological sustainability and changing land use in the Pilbara. Land use change is frequently associated with large changes in key elements of 'sustainability? ? biodiversity, productivity, and water and nutrient cycles. However, in the Pilbara, fires and flooding rains are so frequent that detecting consequences of land use change is frequently confounded by other ?disturbances?. We aim, through controlled field experiments, to disentangle effects of land use change (e.g. de-stocking of range ....Ecological sustainability and changing land use in the Pilbara. Land use change is frequently associated with large changes in key elements of 'sustainability? ? biodiversity, productivity, and water and nutrient cycles. However, in the Pilbara, fires and flooding rains are so frequent that detecting consequences of land use change is frequently confounded by other ?disturbances?. We aim, through controlled field experiments, to disentangle effects of land use change (e.g. de-stocking of rangelands, altered water availability through mining activity or infrastructure) from those of natural disturbance and variability (both spatially and temporally). This research will improve understanding of key areas in resilience of rangelands and of major processes that are critical for sustainable management.Read moreRead less
Unravelling the biochemical fingerprint of Australian native plants for sustainable farm forestry and other applications. Dryland salinity is an issue of national significance due to its impact on primary industries which contribute billions of dollars to our economy. However, millions of hectares of arable land are now affected by salinity, with devastating effects on crops, native plants, water quality and wildlife. This project works with the rural community and exploits the unique gene poo ....Unravelling the biochemical fingerprint of Australian native plants for sustainable farm forestry and other applications. Dryland salinity is an issue of national significance due to its impact on primary industries which contribute billions of dollars to our economy. However, millions of hectares of arable land are now affected by salinity, with devastating effects on crops, native plants, water quality and wildlife. This project works with the rural community and exploits the unique gene pool of certain Australian salinity-tolerant plants for environmental benefits (revegetation, salinity control) and simultaneous economic returns through using these for timber and perennial fodder. The project thus addresses the national priorities of preventing the expansion of salinity, putting it to sustainable uses and preserving biodiversity.Read moreRead less
Dynamics of woody vegetation and water in the central Pilbara - understanding and managing for environmental change. The development and application of technologies and knowledge for enhancing sustainable management of semi-arid environments are of high priority and significant economic, social and environmental benefit. The value of iron ore exports from the Pilbara is expected to grow by nearly 30% in the next year, while the projected production of iron ore over the next 4 years is expected t ....Dynamics of woody vegetation and water in the central Pilbara - understanding and managing for environmental change. The development and application of technologies and knowledge for enhancing sustainable management of semi-arid environments are of high priority and significant economic, social and environmental benefit. The value of iron ore exports from the Pilbara is expected to grow by nearly 30% in the next year, while the projected production of iron ore over the next 4 years is expected to be valued in excess of 60 billion dollars. However, continued and rapid expansion in the development of these resources is contingent on environmental oversight and adoption of an adaptive management approach. This research will thus make a major contribution to understanding the Pilbara ecosystems that provide tremendous economic wealth for all Australians.Read moreRead less