Role Of The Anaphase-Promoting Complex Activator Cdh1 In Oocyte Maturation And Meiotic Aneuploidy
Funder
National Health and Medical Research Council
Funding Amount
$526,878.00
Summary
Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.
Building on rural knowledges to unlock the potential of rural students. This project aims to advance understanding of the distinctive knowledges that rural students bring to school and develop teaching practices that build on these rural knowledges to unlock the potential of this significant student population. The project involves collaborating with rural primary schools, teachers, students and communities to identify rural knowledges, study classroom practices in detail, and develop sustainabl ....Building on rural knowledges to unlock the potential of rural students. This project aims to advance understanding of the distinctive knowledges that rural students bring to school and develop teaching practices that build on these rural knowledges to unlock the potential of this significant student population. The project involves collaborating with rural primary schools, teachers, students and communities to identify rural knowledges, study classroom practices in detail, and develop sustainable teaching practices that help students connect rural knowledges and school knowledge. Expected outcomes include a framework of place-based teaching practices and resources that will benefit rural schooling, teacher education, and the education of communities crucial to the nation’s future wealth and welfare.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100953
Funder
Australian Research Council
Funding Amount
$413,013.00
Summary
Engaging Rural Knowledges in Education for Sustainable Community Futures. This project aims to enhance understanding of the existing and unique knowledges in rural, regional and remote communities and how these can be used to enhance achievement in contemporary, metropolitan-focused, education. The project will generate new understandings about rural knowledge, related influences upon student curriculum access and achievement, and how rural, regional and remote communities understand educational ....Engaging Rural Knowledges in Education for Sustainable Community Futures. This project aims to enhance understanding of the existing and unique knowledges in rural, regional and remote communities and how these can be used to enhance achievement in contemporary, metropolitan-focused, education. The project will generate new understandings about rural knowledge, related influences upon student curriculum access and achievement, and how rural, regional and remote communities understand educational success. Through detailed analysis of data from systems, community focus groups, and school case-studies in six rural, regional and remote communities this project expects to advance knowledge to help make education better meet the needs of rural, regional and remote communities. Read moreRead less
Regional Australia' skills shortages and high-skill refugees' employment . Regional Australia loses to cities thousands of professional and trade-related people whose skills cannot be replaced. Focusing on small and medium-size enterprises producing food and beverages, this project aims to determine whether refugee employment (i) is a strategic resource (ii) can alleviate these chronic regional skill shortages, and (iii) can be integrated in immigration policy. In doing so, it will for the firs ....Regional Australia' skills shortages and high-skill refugees' employment . Regional Australia loses to cities thousands of professional and trade-related people whose skills cannot be replaced. Focusing on small and medium-size enterprises producing food and beverages, this project aims to determine whether refugee employment (i) is a strategic resource (ii) can alleviate these chronic regional skill shortages, and (iii) can be integrated in immigration policy. In doing so, it will for the first time provide critical empirical evidence on the possible need to separate policy measures aimed at rural vs. urban employers. The outcomes will contribute to reducing the problem of critical skill shortages and wastage at once and do so with an eye to the needs to rural Australia – a key driver of the country’s exports. Read moreRead less
Incentivising On Country Aboriginal Employment: Anangu Futures. . This project aims to investigate the changing face of cultural tourism in central Australia and examine pathways towards sustainable aboriginal employment in and around Uluru-Kata Tjuta National Park. The project is significant because it brings together Aboriginal community members, industry and government stakeholders to identify micro-business opportunities, youth training initiatives, better relations across cultural divides, ....Incentivising On Country Aboriginal Employment: Anangu Futures. . This project aims to investigate the changing face of cultural tourism in central Australia and examine pathways towards sustainable aboriginal employment in and around Uluru-Kata Tjuta National Park. The project is significant because it brings together Aboriginal community members, industry and government stakeholders to identify micro-business opportunities, youth training initiatives, better relations across cultural divides, and the economic value of Aboriginal knowledge. Outcomes include a model for sustainable Aboriginal employment in remote and very remote contexts, and the development of culturally relevant and sustainable governing guidelines for regional investment. Benefits include more sustainable jobs for Aboriginal people.Read moreRead less
Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration ....Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration into complex neural networks as well as, (iv) the organisation of neurons into larger 3-dimensional brain structures, namely folding of the human cortex. Further, biomaterials developed here have commercialisation potential, targeted at standardizing the culturing of human stem cells to defined neural populations.
Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101406
Funder
Australian Research Council
Funding Amount
$352,019.00
Summary
Using anthropology of finance to study disaster relief. This project aims to broaden and re-theorise economic definitions of insurance through ethnographic methodologies and feminist studies of finance. Using responses to weather disasters and the financial products created to cover them, the project will explore cultural understandings of protection and damage through a Latin American case that foregrounds experimental and emerging adaptation. In doing so, the research expects to open new direc ....Using anthropology of finance to study disaster relief. This project aims to broaden and re-theorise economic definitions of insurance through ethnographic methodologies and feminist studies of finance. Using responses to weather disasters and the financial products created to cover them, the project will explore cultural understandings of protection and damage through a Latin American case that foregrounds experimental and emerging adaptation. In doing so, the research expects to open new directions in the anthropological study of poverty and contemporary capitalism, and provide working frameworks to understand how financial services can engage meaningfully with communities affected by ever more uncertain weather. This potentially benefits communities managing disaster relief, evidence-based policy development, and public understanding of social and economic protection.Read moreRead less
Life, living and livelihoods in satellite cities: new urban forms in India . This project aims to assess the success of satellite cities, conceived as possible solutions to the urgent challenge of rapid urban growth in today’s megacities. Through an ethnography of an Indian satellite city, Mahindra World City, this project aims to generate knowledge on new urban formations and the consequences of experiments in urban development for different socio-economic groups. Understanding the lived experi ....Life, living and livelihoods in satellite cities: new urban forms in India . This project aims to assess the success of satellite cities, conceived as possible solutions to the urgent challenge of rapid urban growth in today’s megacities. Through an ethnography of an Indian satellite city, Mahindra World City, this project aims to generate knowledge on new urban formations and the consequences of experiments in urban development for different socio-economic groups. Understanding the lived experiences of residents/workers in satellite cities aims to form a robust evidence base for research driven dialogue with policy makers, planners and developers. Lessons derived are expected to inform policy and practice as to how to achieve wellbeing for urban residents, while providing indications of Asia’s urban futures.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100249
Funder
Australian Research Council
Funding Amount
$455,515.00
Summary
Indigenous Sustainable Development Indicators: Closing the data gap . This project aims to demonstrate how Indigenous peoples can contribute to our understanding of and production of indicators to monitor sustainable development. Working with Indigenous communities in Australia and Indonesia as equal partners, the project hopes to address a significant gap in developing innovative methodologies which weaves Indigenous and Western knowledge to produce policy-relevant research. Expected outcomes o ....Indigenous Sustainable Development Indicators: Closing the data gap . This project aims to demonstrate how Indigenous peoples can contribute to our understanding of and production of indicators to monitor sustainable development. Working with Indigenous communities in Australia and Indonesia as equal partners, the project hopes to address a significant gap in developing innovative methodologies which weaves Indigenous and Western knowledge to produce policy-relevant research. Expected outcomes of this project include a set of sustainable development indicators that embed Indigenous worldviews and in a manner that policymakers can utilise. This should provide significant benefits to Indigenous communities in Australia and internationally through enhanced capacity in Indigenous policy design and evaluation.
Read moreRead less
Microenvironments which support extramedullary hematopoiesis. Tissue regeneration is a breakthrough technology absolutely dependent on knowledge of the stem cells and stromal cells which support differentiation and tissue development. This project investigates the stromal cell types in spleen which can regenerate blood-forming cells in an ectopic tissue site or artificial matrix.