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Investigate The Role For Dok Adapter Proteins In Thrombosis And Haemostasis.
Funder
National Health and Medical Research Council
Funding Amount
$161,737.00
Summary
Blood platelets play a key role in blood clot formation, prevention of bleeding and are the principal elements contributing to thrombosis leading to heart attack and stroke. Numerous studies have defined pathways promoting platelet activity, however less is known about their negative regulation. In this fellowship I will examine the role for proteins, Dok2 and Dok1, in the negative regulation of platelets, hoping this leads to development of novel therapeutics for prevention of cardiac disease.
Dynamic Imaging Provides A New Perspective On Biological Function And Disease
Funder
National Health and Medical Research Council
Funding Amount
$391,076.00
Summary
Our ability to reduce the burden of disease is critically limited by our incapacity to image dynamic processes at the heart of those diseases. This application brings completely new capabilities to overcome this shortcoming and hence form new perspectives on several important medical problems that each result in alterations to dynamic processes: asthma, neonatal ventilation and cystic fibrosis within respiratory medicine and atherosclerosis and diabetes within cardiovascular medicine.