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Epigenetic Regulation Of CD8+ T Cell Function And Memory.
Funder
National Health and Medical Research Council
Funding Amount
$578,171.00
Summary
Upon virus infection, a subset of white blood cells, called killer T cells, are recruited to fight the infection. This proposal aims to examine molecular changes that occur within killer T cells and impart their specific function. We also aim to understand how killer T cells are _programmed� as they establish immunological memory. This proposal will provide insights important for the design and improvement of vaccine strategies to fight pathogens such as influenza, HIV and even tumors.
Determining The Biological Significance Of Allelic Sequence Variation Within The T Cell Receptor Loci
Funder
National Health and Medical Research Council
Funding Amount
$627,549.00
Summary
T lymphocytes play a pivotal role in the immune system by recognising virus-infected tissue through the use of highly specific T cell receptors (TCRs). This project will investigate the importance of genetic variation in the TCR genes in influencing how we fight infections. Advances in these areas will assist in understanding susceptibility to some autoimmune diseases as well as aiding in the development of new "intelligent" vaccines and individualised therapeutics.
The Impact Of Micropolymorphism Within The T Cell Receptor Genes And Their Target Antigenic Peptides
Funder
National Health and Medical Research Council
Funding Amount
$365,126.00
Summary
T lymphocytes play a pivotal role in the immune system by recognising virus-infected tissue through the use of highly specific T cell receptors (TCRs). This project will investigate the importance of genetic variation in the TCR genes in influencing how we fight infections. Another aim is to examine how the immune system tolerates genetic variation in an infecting virus. Advances in these areas will aid in the development of new "intelligent" vaccines.
The Role Of Co-signalling Receptors In Cytotoxic Lymphocyte Activity During Infection And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$739,657.00
Summary
Cytotoxic lymphocytes (CLs) are immune cells that detect and kill cancer cells. CLs recognise ‘stress’ proteins on cancer cells through specialised receptors, and this provides the signal for them to kill. However, some cancer cells, such as leukemic cells, can interfere with this recognition to avoid killing by immune cells. This project will investigate the mechanism of recognition and killing of cancer cells by CLs, using both mouse models and cells from patients with acute myeloid leukemia.
Investigations Into The Biology And Functionality Of The Human T Cell Receptor
Funder
National Health and Medical Research Council
Funding Amount
$424,262.00
Summary
T lymphocytes play a pivotal role in the immune system by recognising virus-infected tissue and tumour cells through the use of specific cell surface receptors called T cell receptors (TCR). This project will study why partcular TCRs are used by the immune system, and will also examine the specificity of T cell recognition by determine the range of molecules an individual T cell can recognise. The work will aid in the development of new intelligent vaccines for cancer and infectious disease.
Direct Characterisation Of Naive Epitope-specific T Cell Populations And Their Influence On Immune Responses
Funder
National Health and Medical Research Council
Funding Amount
$314,983.00
Summary
CytotoxicT cells (CTLs) recognize and remove virus infected cells. Both the number and the diversity of T cells involved in the response influence viral clearance. We plan to use a novel technology to directly analyze the numbers and diversity of such CTLs in mice prior to infection. This will clarify how characteristics of cell populations prior to infection define the immune response after infection. This is critical for vaccine design to maximize the efficiency of the immune response.
A Novel CCR2-dependent Niche For CD8+ T Cell Memory
Funder
National Health and Medical Research Council
Funding Amount
$482,549.00
Summary
In this project, we will determine how a protein called CCR2 controls the generation of memory immune responses and whether its activity can be manipulated to enhance vaccination.
The Role Of Long Peptide Epitopes In Antiviral CD8+ T Cell Recognition.
Funder
National Health and Medical Research Council
Funding Amount
$434,652.00
Summary
The immune response to viral infection involves killer T cell recognition of small viral peptides presented by infected cells. Researchers have been attempting to identify the viral peptides that are recognised by T cells. Although these studies have been successful, the major aim of this project is to investigate if the role of unusually long peptides has been underestimated. This project should lead to enhanced monitoring of immune responses and improvements in vaccine design.