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Investigating The Role Of TCR Avidity In Influenza Virus-specific CD8 T Cell Responses
Funder
National Health and Medical Research Council
Funding Amount
$83,142.00
Summary
One of the constituents of the immune system is the cytotoxic, or killer, T cells and these are important in the overall protection from viral infection. Activation of these T cells is mediated by signalling through the T cell receptor (TCR). This study will definitively determine how the strength with which the TCR binds to the activating ligand, can influence the quality of virus-specific T cell immune responses after infection. This has implications for vaccine design.
The Genetics Controlling The Course Of Herpesvirus Infection In Humans
Funder
National Health and Medical Research Council
Funding Amount
$69,684.00
Summary
Epstein-Barr Virus and Human Cytomegalovirus are common viruses present in more than 50% of the adult population. They have a major impact on the human immune system, stimulating large numbers of T cells that are essential to control the persistent viral infection. Generally, these viruses cause few problems; however, an unfortunate minority suffer major life threatening clinical problems. There has also been some evidence for a role of EBV infection in the pathogenesis of Multiple Sclerosis.
The Role Of Epigenetic And Transcriptional Regulation In CD8+ T Cell Effector Gene Expression.
Funder
National Health and Medical Research Council
Funding Amount
$72,571.00
Summary
All cells contain DNA that is tightly wrapped around proteins, whereby changes in the structure allow for the expression of proteins. Cells of the immune system express proteins that can resolve viral infections. This study plans to examine the factors mediating the changes in DNA that allow for the expression of these proteins in immune cells. Insights will enable a greater understanding of how these proteins are generated and maintained, and hence will have implications for vaccine design.