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T cells play a pivotal role in the immune system by recognising viral peptides presented by "HLA" molecules on infected cells through the use of T cell receptors (TCRs). I will investigate the variables that influence T lymphocyte recognition of human herpesvirus infection, including variability in TCR, HLA, and viral genes. Understanding the impact of these variables on how we fight infections will aid in the development of new "intelligent" vaccines and immune-based therapies.
Defining The Cellular Interactions For Initiation And Maintenance Of Immunity To Intracellular Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
This immune system provides our body’s defense against invading organisms like viruses, preventing disease and maintaining health. Immunity involves the interaction of several different cell types that together form arsenals tailored to combat each different infection. Professor Heath will investigate how cells of the immune system orchestrate effective immune responses to viral infections and malaria. He will use this understanding to design novel approaches to vaccination.