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Genetic And Epigenetic Biomarkers In High Risk Colorectal Cancer: Predicting Risk Of Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$64,631.00
Summary
The main aim of this project is to define the prognostic and predictive significance of specific genetic events in patients with high risk (stage III) colorectal cancer. We attempt to explore the differences between primary tumours from patients with and without recurrence at three years. Data from the project will then be used to define a limited set of biomarkers which will aid in clinical decisions regarding the need for adjuvant chemotherapy after surgery for high risk colorectal cancer.
Epigenetics Of Human Placental Development And Pregnancy-associated Disease.
Funder
National Health and Medical Research Council
Funding Amount
$85,526.00
Summary
Mounting evidence suggests that epigenetic changes such as DNA methylation during pregnancy may play an important role in adverse pregnancy outcomes and modulation of disease risk later in life. We have identified a range of distinct DNA methylation events in human placental cells that are likely to play a role in both normal human placentation and aspects of placental dysfunction. We believe that disruption of this epigenetic profile contributes to adverse pregnancy outcomes
MicroRNA Expression And Genome-Wide Epigenetic Analysis Of Paediatric Acute Lymphoblastic Leukaemia (ALL)
Funder
National Health and Medical Research Council
Funding Amount
$71,765.00
Summary
Acute Lymphoblastic Leukaemia (ALL) is one form of childhood leukaemia, the causes for which are unknown. Evidence suggests genome changes are associated with ALL, specifically epigenetic changes such as DNA methylation and microRNA dysregulation. We aim to investigate these changes associated with childhood ALL. We believe this will refine the current diagnostic measures, more accurately predict patients� treatment response, and detect the minimal residual disease during and after treatment.