Determining the social value of extreme, mixed-use urban developments. Using an Adelaide case study, UCity, this project will investigate the social benefit of building mixed-use vertical communities in the Australian urban context. Using an innovative Social Value Framework, the project will establish and demonstrate the multi-dimensional impacts of such developments in practice. The project utilises citizen science for real time auditing of the built environment by residents and users; smart t ....Determining the social value of extreme, mixed-use urban developments. Using an Adelaide case study, UCity, this project will investigate the social benefit of building mixed-use vertical communities in the Australian urban context. Using an innovative Social Value Framework, the project will establish and demonstrate the multi-dimensional impacts of such developments in practice. The project utilises citizen science for real time auditing of the built environment by residents and users; smart technologies for environmental and behavioural monitoring; and data analytics and design automation for spatial analysis of building use. The results will inform new models of sustainable high-rise, mixed-use buildings; providing evidence for a Social Value Framework to become a core consideration in Australian industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100174
Funder
Australian Research Council
Funding Amount
$805,000.00
Summary
Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smar ....Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smart, productive and resilient cities. These capabilities are predicated on the adoption of ISO standards, development of new ontological frameworks and an urban data dictionary to enable semantic inferencing of datasets and the development of data structures and services. This framework would then be applied to data relevant to people, land and urban infrastructure to support comparative and multi-dimensional analytics. Read moreRead less
A Population-based Cohort Investigation Of Postnatal Microbial Experience, Immune Programming And Allergic Disease Risk
Funder
National Health and Medical Research Council
Funding Amount
$1,511,471.00
Summary
This is a population-based longitudinal investigation of the early life host-environment interactions that influence development of the immune system, and the risk of allergic disease. Importantly, this is one of the first studies designed to examine epigenetic programming of the infant immune system in the population setting. Thus we will be able to conduct robust tests of several critical hypotheses that will inform the prevention of allergic disease.
Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.
How Does NF-kB2 Regulate Thymic Selection To Prevent Organ-specific Autoimmune Disease?
Funder
National Health and Medical Research Council
Funding Amount
$787,600.00
Summary
Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.
Innovative procurement theories to optimise education per cost of school. Innovative procurement theories to optimise education per cost of school. This project aims to develop a whole-of-life procurement decision-making framework so schools can make delivering better education more cost effective. This framework—which draws on state-of-the-art and Nobel prize-winning theories and a new theory the project will develop—will be used in government and private schools. The effectiveness of this fram ....Innovative procurement theories to optimise education per cost of school. Innovative procurement theories to optimise education per cost of school. This project aims to develop a whole-of-life procurement decision-making framework so schools can make delivering better education more cost effective. This framework—which draws on state-of-the-art and Nobel prize-winning theories and a new theory the project will develop—will be used in government and private schools. The effectiveness of this framework in improving schools will be shown using a new approach to make school facilities deliver educational outcomes and account for their total production and transaction costs. This research is expected to deliver more efficient ways to future-proof schools to create a well performing school system and more resilient infrastructure vital to Australia’s future prosperity.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100030
Funder
Australian Research Council
Funding Amount
$4,978,958.00
Summary
ARC Training Centre for Next-Gen Architectural Manufacturing. The Centre will generate specialised workforce capacity within Australia’s architectural sector. Leveraging advanced architectural computing discoveries will connect architectural design with the opportunities afforded by advanced manufacturing systems. The Centre will triangulate world-leading researchers, visionary partners, and talented graduates, integrating research into practice through digital business strategies, augmented int ....ARC Training Centre for Next-Gen Architectural Manufacturing. The Centre will generate specialised workforce capacity within Australia’s architectural sector. Leveraging advanced architectural computing discoveries will connect architectural design with the opportunities afforded by advanced manufacturing systems. The Centre will triangulate world-leading researchers, visionary partners, and talented graduates, integrating research into practice through digital business strategies, augmented intelligence, and computing domains of expertise. The Centre’s program of industry-embedded PhD’s, national/international placements, short courses, and post-doctoral projects will co-develop the change agents needed to transform the architectural profession to meet our nation’s immediate strategic needs.Read moreRead less
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
Parametric VR: An Interactive Virtual Reality System for Parametric Design. This project aims to create a new and intuitive set of user interactions for Virtual Reality (VR) to support parametric designers in architecture and design. Parametric tools are an emerging design technology dominating contemporary practices, yet their interfaces are on traditional desktop computers while VR is only employed to visualise the geometric models produced by the end design. This project will generate Paramet ....Parametric VR: An Interactive Virtual Reality System for Parametric Design. This project aims to create a new and intuitive set of user interactions for Virtual Reality (VR) to support parametric designers in architecture and design. Parametric tools are an emerging design technology dominating contemporary practices, yet their interfaces are on traditional desktop computers while VR is only employed to visualise the geometric models produced by the end design. This project will generate Parametric VR, a system of VR tools to support parametric design. Key outcomes include software tools and demonstrators to support parametric algorithms and processes in VR. This will have significant benefits for design industries, allowing designers to directly edit parametric design entirely in VR across the project lifecycle.Read moreRead less