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Cytokine Signalling And The Regulation Of Normal And Leukaemic Blood Cells
Funder
National Health and Medical Research Council
Funding Amount
$948,684.00
Summary
The formation and actions of white blood cells are regulated by protein messengers called cytokines. Cytokines deliver their message by inducing the activation of signalling pathways that orchestrate the cell’s response to infection but when these responses occur too robustly or at inappropriate times they can lead to autoimmune disease, tissue damage and blood cancers. We study the naturally occurring feedback inhibitors of these processes in order to devise new treatments for these diseases.
The Interferon System In Innate Immune Responses To Disease
Funder
National Health and Medical Research Council
Funding Amount
$836,818.00
Summary
My research investigates special proteins called cytokines in the body’s first-line defence against infection, inflammation and cancer. I will characterise how cells respond, the signals that mediate effects, using sophisticated genetic and new computational techniques to manage and analyse data. One focus is a new cytokine we discovered that protects against infections of the reproductive tract –a global health and socio-economic problem affecting 1 billion people.
Understanding Cell Signalling As A Basis For New Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$863,910.00
Summary
This fellowship will capitalise on my extensive expertise in determining the three-dimensional atomic structures of proteins to uncover fundamental biological mechanisms in cancer and Alzheimer’s disease as a basis for discovering new drugs to combat these devastating diseases.
Skeletal structure is continually modified throughout life to take into account dietary, hormonal and physical changes. This is brought about by three major cell types which either form bone, destroy bone, or sense mechanical and hormonal influences on the skeleton. My work seeks to understand the way these cells are controlled and how they control each other. In this way, I will identify new ways of treating osteoporosis, arthritis, skeletal birth defects and cancer-induced bone disease.
The blood system is made up of different types of blood cells (red cells, white cells, platelets etc). The correct number of each type of cell is controlled by chemical messengers called cytokines. Because overactive cytokine signalling can lead to inflammatory disease and leukemia it is tightly controlled by the other molecules in the body. This project aims to determine the exact mechanism whereby this is achieved with the aim of developing therapies to treat inflammatory disease and leukemia.
Understanding And Preventing Inflammatory Pathology Of The Gut
Funder
National Health and Medical Research Council
Funding Amount
$727,758.00
Summary
My research focuses on how inflammation caused by bacteria or organ malfunction can lead to severe disease like cancer in the gastrointestinal tract. Our aim is to better understand diseases like gastric cancer and inflammatory bowel disease, and to develop new ways to detect them and prevent them progressing.
Manipulating The Fine-turning Of The Innate Immune Response In Disease
Funder
National Health and Medical Research Council
Funding Amount
$938,910.00
Summary
I am an international expert on the body’s first-line defense system, the innate immune response. My Fellowship focuses on studying and manipulating innate immune molecules called interferons. My research will lead to improved management of female reproductive disease, autoimmune disorders, infections and cancer through new diagnostics and therapies targeting the interferon system. The basic knowledge I generate on regulating the immune response will be applicable to a range of medical fields.
Molecular Regulation Of Haematopoiesis In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
The blood forming system coordinates production of cells that confer immunity to infection, transport oxygen and assist blood clotting. When the molecular mechanisms that control these functions go awry, diseases including leukaemia and autoimmunity result. This research will define fundamental molecular regulators of blood cell production and function, assess their role in blood cell diseases and explore their potential to provide leads for development of new therapeutics.
The Molecular Basis By Which IL-6 Family Cytokines And Pathogen Recognition Receptors Promote Inflammation-associated Stomach And Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
Lung and stomach cancer are the 2 most lethal cancers world-wide, and represent a growing number of cancers associated with chronic inflammation. However, the genes which trigger inflammation and then promote cancer in certain people remain largely unknown. Using mouse models for these inflammation-associated cancers, together with clinical specimens, our aim is to identify specific genes of the immune system which trigger chronic inflammatory responses that lead to cancer.
Germinal Centres, Rogue B Cells And The Genesis Of Immunological Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
This study will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in autoimmune diseases such as lupus. Targeted studies of a newly discovered "rogue" white blood cell will also provide new clues on how autoimmune diseases arise. In addition, modeling of human immunological disease in mice via CRISPR/Cas9 mutagenesis will provide valuable new insights into their causes and potential treatments.