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Unraveling IL-1F7: A Neglected IL-1 Family Member With Big-Stage Potential
Funder
National Health and Medical Research Council
Funding Amount
$349,590.00
Summary
Cytokines are messenger proteins used by most cells of the body. Since their role as master regulators of many biological processes was discovered, cytokines have enjoyed the limelight of biomedical research. Anti-inflammatory cytokines are particularly coveted as they could replace side effect-prone anti-inflammatory drugs like aspirin. We identified an anti-inflammatory cytokine (IL-1F7) and revealed its protective activity in common, severe diseases like myocardial infarction. We will now exp ....Cytokines are messenger proteins used by most cells of the body. Since their role as master regulators of many biological processes was discovered, cytokines have enjoyed the limelight of biomedical research. Anti-inflammatory cytokines are particularly coveted as they could replace side effect-prone anti-inflammatory drugs like aspirin. We identified an anti-inflammatory cytokine (IL-1F7) and revealed its protective activity in common, severe diseases like myocardial infarction. We will now explore how IL-1F7 exerts is protective properties.Read moreRead less
Development Fo A Novel Treatment For Asthma: The Identification Of Lead Small Molecule Antagonists Of The IL-13/IL-13 Re
Funder
National Health and Medical Research Council
Funding Amount
$99,750.00
Summary
In developed countries Asthma ranks among the most common chronic illnesses. Over two million Australians now have this condition and the cost to our community is estimated to be in excess of $720 million per annum. In 1996 researchers at The Walter and Eliza Hall Institute discovered a new member of the cytokine receptor family, IL-13Ra1, which further research has strongly implicated in the pathology of this disease. The main goal of the proposed research is to discover small molecule antagoni ....In developed countries Asthma ranks among the most common chronic illnesses. Over two million Australians now have this condition and the cost to our community is estimated to be in excess of $720 million per annum. In 1996 researchers at The Walter and Eliza Hall Institute discovered a new member of the cytokine receptor family, IL-13Ra1, which further research has strongly implicated in the pathology of this disease. The main goal of the proposed research is to discover small molecule antagonists of IL-13Ra1 and to identify those suitable for development as novel asthma therapeutics.Read moreRead less
Understanding And Preventing Inflammatory Pathology Of The Gut
Funder
National Health and Medical Research Council
Funding Amount
$727,758.00
Summary
My research focuses on how inflammation caused by bacteria or organ malfunction can lead to severe disease like cancer in the gastrointestinal tract. Our aim is to better understand diseases like gastric cancer and inflammatory bowel disease, and to develop new ways to detect them and prevent them progressing.
Interleukin 38: Uncoupling Innate Inflammation From Interferons In Lupus
Funder
National Health and Medical Research Council
Funding Amount
$1,048,669.00
Summary
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease that affects 5 million patients worldwide, mostly young women. Grave multi-organ inflammation and substantial loss of life expectancy render SLE a critical unmet medical need. We found that the immune system protein interleukin 38 disables several signalling pathways essential for SLE progress. We will explore regulation and function of this protein in cells from healthy people and SLE patients and in models of the disease.
Elucidation Of The Mechanism Of IL-22-Mediated Suppression Of Β-Cell Stress In Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$222,322.00
Summary
Pancreatic ?-cells produce the hormone insulin that controls blood sugar. Type 2 diabetes is characterized by inability of stressed ?-cells to make sufficient insulin to control blood sugar. We discovered that an immune factor, IL-22, protects ?-cells from stress. Treatment of diabetic mice with IL-22 resolves all the major problems in diabetes. This project seeks to reveal the mechanisms by which IL-22 protects ?-cells from stress, with potential for development of novel diabetes therapies.
Pancreatic Targeting Of IL-22 Therapy For Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$484,644.00
Summary
Type 2 diabetes is one of the largest problems facing health care and presents an enormous therapeutic market. Our approach with IL-22 fights the disease at the core of the problem in the pancreatic ?-cells that make insulin. Our patent focuses on targeting IL-22 to the ?-cells which promises to maximise therapeutic benefits while minimising potential adverse effects in other tissues. Independently, and in collaboration with Novo Nordisk, we are making prototype drugs to achieve this.