Phosphate stabilisation of metalliferous mine wastes: The key to solving a major environmental issue? Mine wastes represent the greatest proportion of solid waste produced by mankind. Unconstrained drainage from sulfide-rich mine wastes impacts on water, soil and sediment quality. This project will establish the scientific principles of phosphate stabilisation, which involves the addition of phosphate compounds to mine wastes and soils to permanently contain metals and acid. A solid understandin ....Phosphate stabilisation of metalliferous mine wastes: The key to solving a major environmental issue? Mine wastes represent the greatest proportion of solid waste produced by mankind. Unconstrained drainage from sulfide-rich mine wastes impacts on water, soil and sediment quality. This project will establish the scientific principles of phosphate stabilisation, which involves the addition of phosphate compounds to mine wastes and soils to permanently contain metals and acid. A solid understanding of this emerging technology is a prerequisite for any sustainable management of mine sites. The study will provide the foundation of future management tools needed by landholders, industry and regulators to remediate mined land and waste repositories.Read moreRead less
Deep time in the deep Earth: using trace element diffusivities to constrain durations of deep Earth processes. Evaluation of deep Earth resources requires knowing how long geological processes took, some record of which is often preserved by gradients in the chemical compositions of minerals. Experiments at very high temperatures and pressures will determine how this evidence can be used to constrain the durations of a rich variety of geological processes.
Voltage-dependent structural changes in voltage-gated sodium channels. This project aims to provide insights into the structural rearrangements experienced by Nav channels, which are key components of animal nervous systems. Voltage-gated sodium (Nav) channels initiate action potentials in excitable cells. They open in response to membrane depolarisation then rapidly inactivate. Eukaryotic Nav channels contain four unique voltage-sensor domains (VSDs) that control how the channel responds to mem ....Voltage-dependent structural changes in voltage-gated sodium channels. This project aims to provide insights into the structural rearrangements experienced by Nav channels, which are key components of animal nervous systems. Voltage-gated sodium (Nav) channels initiate action potentials in excitable cells. They open in response to membrane depolarisation then rapidly inactivate. Eukaryotic Nav channels contain four unique voltage-sensor domains (VSDs) that control how the channel responds to membrane potential changes. Recently reported crystal structures of bacterial Nav channels have greatly advanced the field, but these channels contain four identical VSDs and have different inactivation properties. Thus, much remains to be learnt about the conformational plasticity of eukaryotic Nav channel VSDs. The project plans to use animal toxins to capture eukaryotic VSDs in defined states of the gating cycle for detailed structural analysis using nuclear magnetic resonance and X-ray crystallography.Read moreRead less