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An X-ray Crystallographic Investigation Into The Structural Basis Of T-cell Allorecognition
Funder
National Health and Medical Research Council
Funding Amount
$441,000.00
Summary
X-ray crystallography is an essential tool for solving the three-dimensional (3-D) structure of proteins. Proteins control the biological processes within the cell and it is the exact shape of proteins that determines how they function. Each protein is made up like a string of beads, with the building units being amino acids. Depending on the sequence of the amino acids, the protein molecule bends and forms a distinct, complex shape. This three dimensional shape allows it to specifically interac ....X-ray crystallography is an essential tool for solving the three-dimensional (3-D) structure of proteins. Proteins control the biological processes within the cell and it is the exact shape of proteins that determines how they function. Each protein is made up like a string of beads, with the building units being amino acids. Depending on the sequence of the amino acids, the protein molecule bends and forms a distinct, complex shape. This three dimensional shape allows it to specifically interact with carbohydrates, other proteins, such as enzymes or receptors, or even with molecules like DNA, to have its effect. To determine how a protein acts, it is vital to know the precise three-dimensional shape of a protein at the atomic level. This work is focused on understanding the precise shape of proteins that control the immune system. The immune system is avital process whereby individuals can fight off disease. This work will further our understanding of the immune system.Read moreRead less
Taking The First Steps From Promise To Product: Exploration Of The Newly Discovered Interleukin 37 Receptor Complex And Its Signaling Pathways
Funder
National Health and Medical Research Council
Funding Amount
$694,623.00
Summary
Cytokines are messenger proteins used by most cells of the body. They function as master regulators of many biological processes and as such play an important role in a wide spectrum of diseases. Anti-inflammatory cytokines attenuate the potentially destructive force of other cytokines and the immune system as a whole, and are therefore coveted as drug targets. We discovered the formidable anti-inflammatory properties of IL-37 and will now explore how these activites can be utilised in clinical ....Cytokines are messenger proteins used by most cells of the body. They function as master regulators of many biological processes and as such play an important role in a wide spectrum of diseases. Anti-inflammatory cytokines attenuate the potentially destructive force of other cytokines and the immune system as a whole, and are therefore coveted as drug targets. We discovered the formidable anti-inflammatory properties of IL-37 and will now explore how these activites can be utilised in clinical medicine.Read moreRead less