The Role Of Non-classical MHC Class I Molecules In Adaptive Immunity
Funder
National Health and Medical Research Council
Funding Amount
$443,834.00
Summary
Specialised proteins called MHC class Ia molecules (MHC-Ia) stimulate killer T cells to lyse virus infected cells. In contrast, the function of the closely related MHC-Ib is uncertain. Recent findings have demonstrated that MHC-Ib can also be recognised by T cells and this interaction is important in the control of viral infections. However, despite the similarity to MHC-Ia, it is unclear how this interaction occurs. This project aims to investigate how killer T cells recognise MHC-Ib molecules.
Improving Ways Of Thinking And Ways Of Doing Aboriginal And Cross-cultural Health In General Practice
Funder
National Health and Medical Research Council
Funding Amount
$948,465.00
Summary
Aboriginal community controlled health services and private general practice need to work together to close the gap. This practice-based cultural respect program and toolkit establishes a care partnership, with Aboriginal cultural mentors, to support strategies to embed cultural respect in general practices on an ongoing basis. Success indicators include a cultural quotient measure, performance of Aboriginal health checks and management of risk factors. The program may also benefit cross-cultura ....Aboriginal community controlled health services and private general practice need to work together to close the gap. This practice-based cultural respect program and toolkit establishes a care partnership, with Aboriginal cultural mentors, to support strategies to embed cultural respect in general practices on an ongoing basis. Success indicators include a cultural quotient measure, performance of Aboriginal health checks and management of risk factors. The program may also benefit cross-cultural health generally.Read moreRead less
Functional Suicide Of Selected Dendritic Cells By Cytochrome C: An In Vivo Model Lacking Cross-presentation
Funder
National Health and Medical Research Council
Funding Amount
$597,476.00
Summary
Certain white blood cells (dendritic cells) activate the immune system, especially its T cells. Infection of such cells elicits killer T cell responses. However not all infections infect dendritic cells. In such cases, the infectious material is eaten by dendritic cells and moved to certain areas within the cell. This process is called cross-presentation and how important it is during various diseases remains moot. We now have a model of testing this by eliminating these cross-presenting cells.
Career aspirations of Australia's immigrant managers from the Asia-Pacific region: Developing a cross-cultural framework. For over a decade, Asian migration has dominated Australia's expanding skilled migration intake. However, there has been little appreciation of cross-cultural influences on career management, which have implications for employees' personal fulfilment and job satisfaction. This project, in advancing understanding of the interplays of cultural background and managerial career a ....Career aspirations of Australia's immigrant managers from the Asia-Pacific region: Developing a cross-cultural framework. For over a decade, Asian migration has dominated Australia's expanding skilled migration intake. However, there has been little appreciation of cross-cultural influences on career management, which have implications for employees' personal fulfilment and job satisfaction. This project, in advancing understanding of the interplays of cultural background and managerial career aspirations of the newcomers, will assist Australian organisations in developing culturally-sensitive policies and programs in the workplace.It will aid both organisations and government authorities in furthering their goals of promoting regional economic partnerships through increased understanding and engagement with our Asia-Pacific neighbours.Read moreRead less
An investigation of illicit tobacco use - its prevalence, economic impact and the motivations and perceptions of consumers. Black market tobacco costs the Australian government at least $450 million in lost taxes per annum. Little is known about the prevalence and economics of illicit tobacco use, or the motivations, attitudes and perceptions of consumers. Using a national telephone survey of licit and illicit tobacco consumers, we will investigate their economic thresholds, decision-making pr ....An investigation of illicit tobacco use - its prevalence, economic impact and the motivations and perceptions of consumers. Black market tobacco costs the Australian government at least $450 million in lost taxes per annum. Little is known about the prevalence and economics of illicit tobacco use, or the motivations, attitudes and perceptions of consumers. Using a national telephone survey of licit and illicit tobacco consumers, we will investigate their economic thresholds, decision-making processes, and perceptions of health effects. Our work will lead to improved supply and demand reduction measures for illicit tobacco, and enable development of appropriately targeted health promotion strategies, generating enduring benefit to Australia's economy and public health. Read moreRead less
Supporting adaptive diagrammatic communication. The computing environment of the near future will allow users to access and
interact with digital information using an incredible variety of devices.
Regardless of these changes, humans will still be communicating using
diagrams and sketches. But unlike today where diagrams are static,
lifeless objects reflecting their origin in print media, the computer of
the near future will provide more flexible visual computer interfaces which
support ....Supporting adaptive diagrammatic communication. The computing environment of the near future will allow users to access and
interact with digital information using an incredible variety of devices.
Regardless of these changes, humans will still be communicating using
diagrams and sketches. But unlike today where diagrams are static,
lifeless objects reflecting their origin in print media, the computer of
the near future will provide more flexible visual computer interfaces which
support adaptive layout, user interaction and semantics based retrieval.
Based on geometric constraint solving, this project will provide a
generic computational basis for this radically new view of diagrams.
Read moreRead less
Becoming at home: the good starts for refugee youth cohort, transition to early adulthood and settlement outcomes. This project follows a cohort of young adults with refugee backgrounds who have been living in Australia for around ten years, and will examine settlement and social integration outcomes. This study will provide a robust evidence-base that can inform humanitarian settlement policy and programs.