Rapidly giving intravenous fluid to prevent or treat shock (fluid resuscitation) is one of the commonest treatments given to critically ill patients. Current guidelines recommend crystalloid solutions but it is unknown whether any particular crystalloid is better than others. This trial will determine whether the use of one of two crystalloid fluids, saline or PlasmaLyte, reduces the risk of organ injuries, such as kidney failure, and improves patients chances of surviving critically illness.
Re-EValuating The Inhibition Of Stress Erosions (REVISE): Gastrointestinal Bleeding Prophylaxis In ICU
Funder
National Health and Medical Research Council
Funding Amount
$2,955,164.00
Summary
Around 50,000 patients in Australian Intensive Care Units receive a drug called pantoprazole each year with the aim of preventing bleeding from the gut. Recent research suggests this practice is ineffective and may harm patients by increasing their risk of serious infections. We will perform a definitive study to determine whether the widespread use of pantoprazole is beneficial or harmful.
Improving The Cardiometabolic Health Of People With Psychosis: The Physical Health Nurse Consultant Service
Funder
National Health and Medical Research Council
Funding Amount
$667,021.00
Summary
People with psychosis have high rates of chronic disease that reduces lifespan by 25 years. The health system struggles to provide adequate care. We developed the Physical Health Nurse Consultant service that provides physical health care coordination and will evaluate whether it improves physical health, consumer experience and cost-effectiveness. Outcomes will directly address policy initiatives to improve physical health service delivery in mental health services.
Discovery Early Career Researcher Award - Grant ID: DE160100473
Funder
Australian Research Council
Funding Amount
$346,434.00
Summary
The invention of collateral damage and the changing moral economy of war. This project aims to provide a novel philosophical account of the invention of the concept of collateral damage in war. It seeks to understand the historical and institutional processes that have produced a moral distinction between deliberate harm inflicted on non-combatants, and the non-intentional harm that is seen as an inevitable side effect of modern warfare. Drawing on archival material and military manuals, and com ....The invention of collateral damage and the changing moral economy of war. This project aims to provide a novel philosophical account of the invention of the concept of collateral damage in war. It seeks to understand the historical and institutional processes that have produced a moral distinction between deliberate harm inflicted on non-combatants, and the non-intentional harm that is seen as an inevitable side effect of modern warfare. Drawing on archival material and military manuals, and combining insights from the history of human rights and contemporary European political philosophy, the project aims to produce a sophisticated philosophical framework for understanding the social and political implications of conceiving civilian deaths as collateral damage to contribute to public debate about the human costs of war.Read moreRead less
Selective Estrogen Receptor Modulators (SERMs) - A Potential New Treatment For Women Of Child-bearing Age With Psychotic Symptoms Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$210,480.00
Summary
Schizophrenia is a devastating illness urgently requiring a new treatment approach. We have discovered that estrogen is an effective treatment for women with schizophrenia and are currently trialling a safer Selective Estrogen Receptor Modulator (SERM) known as brain estrogen� in postmenopausal women with schizophrenia. Regulatory permission is now available to trial the SERM in younger women, and we seek to extend our current SERM study into child bearing age women with schizophrenia.
Policing Australian Popular Music. This project will be the first comprehensive study of the relationship between policing and popular music in Australia. An interdisciplinary approach brings together criminology, music, history, social work, cultural, and music education research to investigate the processes by which certain forms of popular music and affiliated communities have been criminalised, and the ways musicians and musical communities have voiced resistance to police and state power. T ....Policing Australian Popular Music. This project will be the first comprehensive study of the relationship between policing and popular music in Australia. An interdisciplinary approach brings together criminology, music, history, social work, cultural, and music education research to investigate the processes by which certain forms of popular music and affiliated communities have been criminalised, and the ways musicians and musical communities have voiced resistance to police and state power. Through innovative interview and arts-practice based methodologies, the project will generate new knowledge on the historic and contemporary relations between state governance and creative cultural expression to inform policy and practice in policing as well as cultural investments. Read moreRead less
Improving The Mental Health Outcomes Of People With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$1,189,979.00
Summary
Australians with intellectual disability (ID) have very high rates of mental illness but experience very poor access to mental health services. Our research will develop a sound evidence base on the profile of mental ill health, service use, pathways to care and mental health policy for people with intellectual disability. Together with consumers and support persons we will examine ways to improve mental health services for people with intellectual disability.
From Brain Maps To Mechanisms: Modeling The Pathophysiology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My Fellowship will develop a framework that integrates brain imaging data with mathematical models of the brain to help understand the mechanisms responsible for schizophrenia. By linking functional Magnetic Resonance Imaging (fMRI) measurements to models of their underlying causes, the work may lead to new treatments that target the specific dysfunction in individuals with this debilitating brain disorder.
A Randomised Control Trial Of Non-specific Clinical Management Versus CBT In Chronic Anorexia Nervosa
Funder
National Health and Medical Research Council
Funding Amount
$555,843.00
Summary
Anorexia nervosa (AN) is a serious mental illness that usually starts in adolescence and often runs a chronic course. With an estimated prevalence rate between 0.5% and 3.7% of women, and up to 50% remaining chronically ill, the illness poses a disproportionate burden on health and social services. AN has inpatient costs alone that exceed that for schizophrenia. Chronic AN has the highest mortality rate of any mental illness. Chronic AN patients are known for their ambivalence about engaging in ....Anorexia nervosa (AN) is a serious mental illness that usually starts in adolescence and often runs a chronic course. With an estimated prevalence rate between 0.5% and 3.7% of women, and up to 50% remaining chronically ill, the illness poses a disproportionate burden on health and social services. AN has inpatient costs alone that exceed that for schizophrenia. Chronic AN has the highest mortality rate of any mental illness. Chronic AN patients are known for their ambivalence about engaging in treatment and poor motivation to change their eating disorder behaviours. They often fail to respond to traditional treatments and develop a history of negative treatment experiences and repeated treatment failures. A new approach is needed to reduce both the personal suffering and the burden of the illness on social and medical services. To date, there has been little scientific investigation into the development of specific treatment for those patients with chronic AN. This study will trial a recently manualised therapy - non-specific supportive clinical management - which initial evidence suggests may hold promise for chronic AN because it offers a more indirect, motivationally-matched approach. This treatment will be compared to the establishment therapy Cognitive Behavioural Therapy. Patients will be randomly allocated to one of the two treatment conditions and will receive 40 sessions over 12 months. They will be thoroughly assessed prior to during and after they have completed treatment and followed up for 6 months. This is the worlds first trial of a psychological treatment for chronic AN; it is hoped the study will establish an effective treatment for this debilitating and expensive illness. Further, as the project aims to explore the core, but often over-looked, feature of AN - poor motivation for recovery - it will also be in a position to shed light on the deep psychological processes that maintain this illness.Read moreRead less
Nuclear Nation: a contemporary archaeology of Australia's atomic heritage. The history of nuclear science in Australia is of growing interest to scholars, however the physical remains of this controversial legacy are yet to be investigated. This interdisciplinary project would bring together leading academics, curators, scientists and First Nations researchers, using innovative contemporary archaeology approaches, to generate new understandings of the significance of Australia’s atomic heritage ....Nuclear Nation: a contemporary archaeology of Australia's atomic heritage. The history of nuclear science in Australia is of growing interest to scholars, however the physical remains of this controversial legacy are yet to be investigated. This interdisciplinary project would bring together leading academics, curators, scientists and First Nations researchers, using innovative contemporary archaeology approaches, to generate new understandings of the significance of Australia’s atomic heritage in global context. Expected outcomes include improved capacity for heritage management, and new resources and methods for understanding and interpreting Australia’s role in the Nuclear Age. This should generate substantial benefits for the Partner Organisations, and for Australia's tourism and cultural sectors more broadly.Read moreRead less