Defining The Role Of IGF-1 As A Novel Angiocrine Factor In The Development And Treament Of Common Craniofacial Disorders
Funder
National Health and Medical Research Council
Funding Amount
$573,848.00
Summary
1 in 1000 children are born with a small jaw, which requires invasive surgery for treatment. We identified that defects in blood vessel development in the jaw underlie some cases of these craniofacial defects. We found that factors secreted from the major artery in the jaw can promote jaw growth, and our research proposal aims to identify what exactly these factors are. These factors have the potential to be used to therapeutically treat children with a small jaw to help it grow correctly.
Identifying The Critical Pathways Which Regulate Vertebrate Craniofacial Development
Funder
National Health and Medical Research Council
Funding Amount
$552,131.00
Summary
Understanding the genes which underlie human birth defects is of immense clinical importance. Our laboratory is a world-leader investigating a gene responsible for facial skeleton development, Grhl2. With our wide range of models, we will discover how Grhl2 works to ensure the face and skull develop properly during birth.
The use of outcrop analogues to characterise large-scale deepwater sedimentary architecture. Deepwater turbidite sedimentary systems are one of the modern frontiers in petroleum exploration, with many major discoveries expected from around the world in the next 25 years. Technological advances in the drilling and production of the deepwater hydrocarbons now enable the exploration and exploitation in this realm. However, the geometry, internal architecture and spatial variations of deepwater sand ....The use of outcrop analogues to characterise large-scale deepwater sedimentary architecture. Deepwater turbidite sedimentary systems are one of the modern frontiers in petroleum exploration, with many major discoveries expected from around the world in the next 25 years. Technological advances in the drilling and production of the deepwater hydrocarbons now enable the exploration and exploitation in this realm. However, the geometry, internal architecture and spatial variations of deepwater sandbodies are still poorly understood. By using state-of-the-art outcrop, modern submarine fan and petroleum exploration data, this research project will improve the understanding of the reservoir geometry and internal architecture of deepwater sandbodies. The results will aid in the exploration and development of hydrocarbons in deepwater sedimentary systems.Read moreRead less
Mechanisms Of Premature Cranial Fusion: Role Of Retinol Binding Protein 4 In Osteogenesis And Suture Fusion
Funder
National Health and Medical Research Council
Funding Amount
$555,855.00
Summary
Craniosynostosis is a condition where the skull bones fuse prematurely, affecting skull shape, vision and cognition. It occurs in 1 in 2,500 births. The only treatment is surgery, which is life-threatening, costly and may need to be repeated. By studying how fusion happens in this project we may be able to devise therapies to minimize the risks and need for re-operation. Here, we hope to show that modification of a single substance in the skull of mouse models can prevent premature bone fusion.
Constraining the snowball earth: timing and duration of neoproterozoic glaciations using precise Re-Os geochronology. This project aims to investigate the onset and duration of major global glacial events during the period of Earth history when metazoan life first appeared. Understanding such processes will enable insights into both the rate and nature of evolutionary processes, and place constraints of ancient and modern climate models. This will be achieved by establishing a facility to obtain ....Constraining the snowball earth: timing and duration of neoproterozoic glaciations using precise Re-Os geochronology. This project aims to investigate the onset and duration of major global glacial events during the period of Earth history when metazoan life first appeared. Understanding such processes will enable insights into both the rate and nature of evolutionary processes, and place constraints of ancient and modern climate models. This will be achieved by establishing a facility to obtain precise Re-Os isotope age data from sediments at Adelaide University (only the second such in the world), and studying sedimentary rocks preserved in the Centralian Superbasin. A basis for global stratigraphic correlation will also result from the intended program of work.Read moreRead less
Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entir ....Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entirely new exploration model for deepwater hydrocarbons, 2) provided new expertise and seabed maps for generating a superior marine naval defence capability.Read moreRead less
The stratigraphic architecture of continental margins (MARGINS). The project seeks to increase our understanding of how continental margins develop. Emphasis is given to studying the controls exerted on sedimentation by sea-level change, climate cycling, ocean front location, current-deposition and tectonics, using the southwest Pacific (temperate eastern NZ) as the prime fieldwork area. Sediment being transported across continental margins passes through a number of energy fences (e.g. piedmont ....The stratigraphic architecture of continental margins (MARGINS). The project seeks to increase our understanding of how continental margins develop. Emphasis is given to studying the controls exerted on sedimentation by sea-level change, climate cycling, ocean front location, current-deposition and tectonics, using the southwest Pacific (temperate eastern NZ) as the prime fieldwork area. Sediment being transported across continental margins passes through a number of energy fences (e.g. piedmont, shoreline, wave-base, storm-zone, shelf-edge), which together modulate sediment transport and deposition. These fences differ in their relative positions, magnitudes and effects on different margins. The research will combine onland and offshore studies, builds on data collected during ODP Leg 181, and is integrated with the international MARGINS "source to sink" program.Read moreRead less
Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students train ....Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students trained in advanced computational methods suitable for the evolving Australian oil and gas industry; and a software product that has high commericalisation potential. The project will transfer knowledge from European industry and universities to Australia and has applications for mineral prospectivity in sedimentary basins. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
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New Stratigraphy and Geostatistics for Gas and Water Resources . Management of gas and water resources is of significant importance to the Australian economy and society. Industry and government use digital modelling to assist in resources management. The first step in modelling is to correlate geological data and then use geostatistics to estimate properties in areas without data. This project aims to produce a new geological framework for the Surat Basin underpinned by new zircon ages and ages ....New Stratigraphy and Geostatistics for Gas and Water Resources . Management of gas and water resources is of significant importance to the Australian economy and society. Industry and government use digital modelling to assist in resources management. The first step in modelling is to correlate geological data and then use geostatistics to estimate properties in areas without data. This project aims to produce a new geological framework for the Surat Basin underpinned by new zircon ages and ages of fossils in sediments and a new geostatistical methodology to better represent flow properties in coal seams and aquifers. This is expected result in a more accurate modelling methodology that can be used by industry and government for modelling resources, including in other basins in Australia and worldwide.Read moreRead less