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A Longitudinal Neuroimaging Study Investigating Reorganisation Of Cerebellar-cerebral Networks In Friedreich Ataxia
Funder
National Health and Medical Research Council
Funding Amount
$816,908.00
Summary
Friedreich ataxia (FRDA) causes debilitating motor and cognitive deficits. We propose a longitudinal multi-modal magnetic resonance (MR) imaging study to measure different types of tissue in the brain in this disease. We seek to understand how the brain reorganises itself due to cell loss in the spinal cord, cerebellum and cerebral cortex. This study will establish sensitivity of a range of MR imaging measures as potential biomarkers for use in large multi-centre drug trials in this disease.
Pathophysiology, Site Of Disease Onset And Mechanisms Of Spread In Amyotrophic Lateral Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$704,270.00
Summary
Amyotrophic lateral sclerosis (ALS) is a fatal disease of the human motor system resulting in progressive paralysis of voluntary muscles and death within 5 years of symptom onset. A key unresolved issue in the understanding of where ALS starts and what factors drive the disease. This project will utilise sophisticated techniques to determine the site of onset, factors controlling disease spread and ultimately identify treatment targets that could slow down or even stop disease progression.
Investigating The Neural Mechanisms Of Visual Recovery After Acute Optic Neuritis
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Patients with multiple sclerosis experience relapses followed by disease remission. Recently, neuroplasticity, or the brain's innate ability to reorganise itself to maintain function after injury, has been thought to play a significant role in remission. We study patients with optic neuritis, which causes loss of vision, to understand visual parts of the brain change during recovery to enable patients to see again despite ongoing brain injury.